IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Genetic Variants of Toll-Like Receptor 2 and 5, Helicobacter Pylori Infection, and Risk of Gastric Cancer and Its Precursors in a Chinese Population
Zeng, Hong-Mei; Pan, Kai-Feng1; Zhang, Yang; Zhang, Lian; Ma, Jun-Ling; Zhou, Tong; Su, Hui-Juan; Li, Wen-Qing; Li, Ji-You2; Gerhard, Markus3; Classen, Meinhard3; You, Wei-Cheng
刊名CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
2011-12-01
DOI10.1158/1055-9965.EPI-11-0702
20期:12页:2594-2602
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Public, Environmental & Occupational Health
资助者National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Key International S&amp ; T Cooperation Project ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Key International S&amp ; T Cooperation Project
研究领域[WOS]Oncology ; Public, Environmental & Occupational Health
关键词[WOS]SYSTEMIC-LUPUS-ERYTHEMATOSUS ; STOP CODON POLYMORPHISM ; IMMUNE-RESPONSES ; COLORECTAL-CANCER ; EPITHELIAL-CELLS ; TLR5 ; SUSCEPTIBILITY ; JAPANESE ; EXPRESSION ; CARCINOMA
英文摘要

Background: Genetic polymorphisms of Toll-like receptors (TLR) may influence the outcome of Helicobacter pylori infection and play important roles in gastric carcinogenesis. To screen the genetic variants of TLR2 and TLR5, and evaluate their associations with gastric cancer (GC) and its precursors, a population-based study was conducted in Linqu County, Shandong Province, China.

Methods: Genetic variants were identified by PCR-based denaturing high-performance liquid chromatography and PCR-restriction fragment length polymorphism analysis in 248 GC cases, 846 subjects with advanced gastric lesions including 350 dysplasia and 496 intestinal metaplasia, and 496 superficial gastritis/mild chronic atrophic gastritis controls.

Results: Nine allelic variants each were detected within the promoter and exons of TLR2 and TLR5. Among those, TLR2 c. -196 to -174 del carriers (ins/del+del/del)showed a significantly decreased risk of GC (adjusted OR, 0.66; 95% CI: 0.48-0.90), whereas TLR5 rs5744174C carriers (TC+CC) had an increased risk of GC (OR, 1.43; 95% CI: 1.03-1.97). Further analysis indicated an elevated risk of GC in subjects with the TLR5 rs5744174 TC+CC genotype and H. pylori infection (OR, 3.35; 95% CI: 2.13-5.26), and a significant interaction between rs5744174 and H. pylori infection was observed (OR, 2.15; 95% CI: 1.12-4.16).

Conclusion: These findings suggest that TLR2 c. -196 to -174 ins> del, TLR5 rs5744174 and interaction between rs5744174 and H. pylori infection were associated with the development of GC.

Impact: TLR2 and TLR5 polymorphisms may play important roles in the process of H. pylori-related gastric carcinogenesis. Cancer Epidemiol Biomarkers Prev; 20(12); 2594-602. (C) 2011 AACR.

语种英语
所属项目编号2010CB529303 ; 30772515 ; 2010DFB30310
资助者National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Key International S&amp ; T Cooperation Project ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Key International S&amp ; T Cooperation Project
WOS记录号WOS:000298234900015
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66390
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Dept Canc Epidemiol,Minist Educ, Canc Hosp & Inst,Key Lab Carcinogenesis & Transla, Beijing 100142, Peoples R China
2.Tech Univ Munich, Munich, Germany
3.Peking Univ, Dept Pathol, Canc Hosp & Inst, Beijing 100142, Peoples R China
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GB/T 7714
Zeng, Hong-Mei,Pan, Kai-Feng,Zhang, Yang,et al. Genetic Variants of Toll-Like Receptor 2 and 5, Helicobacter Pylori Infection, and Risk of Gastric Cancer and Its Precursors in a Chinese Population[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2011,20(12):2594-2602.
APA Zeng, Hong-Mei.,Pan, Kai-Feng.,Zhang, Yang.,Zhang, Lian.,Ma, Jun-Ling.,...&You, Wei-Cheng.(2011).Genetic Variants of Toll-Like Receptor 2 and 5, Helicobacter Pylori Infection, and Risk of Gastric Cancer and Its Precursors in a Chinese Population.CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,20(12),2594-2602.
MLA Zeng, Hong-Mei,et al."Genetic Variants of Toll-Like Receptor 2 and 5, Helicobacter Pylori Infection, and Risk of Gastric Cancer and Its Precursors in a Chinese Population".CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 20.12(2011):2594-2602.
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