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学科主题: 临床医学
题名:
Decreased Interferon Alpha/Beta Signature Associated with Human Lung Tumorigenesis
作者: Tong, Run1,2; Feng, Lin1,2; Zhang, Lei2,3; Zhang, Jianzhi4; Mao, Yousheng2,5; Zhang, Kaitai1,2; Gao, Yanning1,2,3; Wang, Guiqi2; Cheng, Shujun1,2
刊名: JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
发表日期: 2015-12-01
DOI: 10.1089/jir.2015.0061
卷: 35, 期:12, 页:963-968
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Immunology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Immunology
关键词[WOS]: SET ENRICHMENT ANALYSIS ; GENE-EXPRESSION ; I INTERFERONS ; CANCER ; AIRWAY ; INTEGRATION ; RESPONSES ; DEFENSE ; TUMORS ; CELLS
英文摘要:

Accumulating evidence suggests that interferon (IFN) alpha/beta are involved in antitumor immunity and cancer immunoediting, but information on the antitumor effects of IFN alpha/beta in lung cancer is limited. In our study, we elucidated the IFN alpha/beta signature during both human fetal lung development and lung tumorigenesis. Our findings indicated gradual upregulation in the IFN alpha/beta signature during human fetal lung development. In addition, this signature was progressively downregulated in normal human airway epithelial cells from lung cancer patients, in immortalized human bronchial epithelial cell lines from later passages, in late-stage lung squamous cell carcinoma (LSCC) tissues, and in LSCC tissues exhibiting lymph node metastasis. Therefore, from its earliest stages, lung tumorigenesis may be associated with a decreased IFN alpha/beta signature. This association may provide insight to guide the detection of high-risk lung cancer patients.

语种: 英语
所属项目编号: 2014AA020602 ; Z111107067311018
项目资助者: National High Technology Research and Development Program of China (863 Program) ; Beijing Science and Technology Plan Projects
WOS记录号: WOS:000366604400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66399
Appears in Collections:北京大学临床肿瘤学院_胸外科_期刊论文

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作者单位: 1.Peking Union Med Coll, Dept Etiol & Carcinogenesis, Canc Hosp & Inst, State Key Lab Mol Oncol, Beijing 100021, Peoples R China
2.Chinese Acad Med Sci, Beijing 100021, Peoples R China
3.Peking Union Med Coll, Dept Endoscopy, Canc Hosp & Inst, Beijing 100021, Peoples R China
4.Peking Univ, Dept Thorac Surg, Sch Oncol,Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
5.Peking Union Med Coll, Dept Thorac Surg, Canc Hosp & Inst, Beijing 100021, Peoples R China

Recommended Citation:
Tong, Run,Feng, Lin,Zhang, Lei,et al. Decreased Interferon Alpha/Beta Signature Associated with Human Lung Tumorigenesis[J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,2015,35(12):963-968.
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