IR@PKUHSC  > 北京大学临床肿瘤学院  > 胸外科
学科主题临床医学
Decreased Interferon Alpha/Beta Signature Associated with Human Lung Tumorigenesis
Tong, Run1,2; Feng, Lin1,2; Zhang, Lei2,3; Zhang, Jianzhi4; Mao, Yousheng2,5; Zhang, Kaitai1,2; Gao, Yanning1,2,3; Wang, Guiqi2; Cheng, Shujun1,2
刊名JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
2015-12-01
DOI10.1089/jir.2015.0061
35期:12页:963-968
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Immunology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Immunology
关键词[WOS]SET ENRICHMENT ANALYSIS ; GENE-EXPRESSION ; I INTERFERONS ; CANCER ; AIRWAY ; INTEGRATION ; RESPONSES ; DEFENSE ; TUMORS ; CELLS
英文摘要

Accumulating evidence suggests that interferon (IFN) alpha/beta are involved in antitumor immunity and cancer immunoediting, but information on the antitumor effects of IFN alpha/beta in lung cancer is limited. In our study, we elucidated the IFN alpha/beta signature during both human fetal lung development and lung tumorigenesis. Our findings indicated gradual upregulation in the IFN alpha/beta signature during human fetal lung development. In addition, this signature was progressively downregulated in normal human airway epithelial cells from lung cancer patients, in immortalized human bronchial epithelial cell lines from later passages, in late-stage lung squamous cell carcinoma (LSCC) tissues, and in LSCC tissues exhibiting lymph node metastasis. Therefore, from its earliest stages, lung tumorigenesis may be associated with a decreased IFN alpha/beta signature. This association may provide insight to guide the detection of high-risk lung cancer patients.

语种英语
WOS记录号WOS:000366604400005
项目编号2014AA020602 ; Z111107067311018
资助机构National High Technology Research and Development Program of China (863 Program) ; Beijing Science and Technology Plan Projects
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66399
专题北京大学临床肿瘤学院_胸外科
北京大学临床肿瘤学院_胸部肿瘤外二科
作者单位1.Peking Union Med Coll, Dept Etiol & Carcinogenesis, Canc Hosp & Inst, State Key Lab Mol Oncol, Beijing 100021, Peoples R China
2.Chinese Acad Med Sci, Beijing 100021, Peoples R China
3.Peking Union Med Coll, Dept Endoscopy, Canc Hosp & Inst, Beijing 100021, Peoples R China
4.Peking Univ, Dept Thorac Surg, Sch Oncol,Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
5.Peking Union Med Coll, Dept Thorac Surg, Canc Hosp & Inst, Beijing 100021, Peoples R China
推荐引用方式
GB/T 7714
Tong, Run,Feng, Lin,Zhang, Lei,et al. Decreased Interferon Alpha/Beta Signature Associated with Human Lung Tumorigenesis[J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,2015,35(12):963-968.
APA Tong, Run.,Feng, Lin.,Zhang, Lei.,Zhang, Jianzhi.,Mao, Yousheng.,...&Cheng, Shujun.(2015).Decreased Interferon Alpha/Beta Signature Associated with Human Lung Tumorigenesis.JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,35(12),963-968.
MLA Tong, Run,et al."Decreased Interferon Alpha/Beta Signature Associated with Human Lung Tumorigenesis".JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 35.12(2015):963-968.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Tong, Run]的文章
[Feng, Lin]的文章
[Zhang, Lei]的文章
百度学术
百度学术中相似的文章
[Tong, Run]的文章
[Feng, Lin]的文章
[Zhang, Lei]的文章
必应学术
必应学术中相似的文章
[Tong, Run]的文章
[Feng, Lin]的文章
[Zhang, Lei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。