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学科主题: 临床医学
题名:
Serial measurement of serum basic fibroblast growth factor in patients with acute cerebral infarction
作者: Guo, HL; Huang, L; Cheng, M; Jin, X; Zhao, YF; Yi, M
关键词: cerebral infarction ; brain ischemia ; stroke ; basic fibroblast growth factor ; infarction size ; Scandinavian Stroke Scale
刊名: NEUROSCIENCE LETTERS
发表日期: 2006-01-23
DOI: 10.1016/j.neulet.2005.09.043
卷: 393, 期:1, 页:56-59
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: HIPPOCAMPAL-NEURONS ; ISCHEMIC-STROKE ; NERVOUS-SYSTEM ; ANGIOGENESIS ; MODEL ; RAT ; EXPRESSION ; INDUCTION ; HEPARIN ; HYPOXIA
英文摘要:

Basic fibroblast growth factor (bFGF) has been reported to be involved in the pathophysiological changes following cerebral infarction. Basic fibroblast growth factor is upregulated in the brain and conduces to neuroprotection and angiogenesis in experimental brain ischemia, but the change of serum bFGF in cerebral infarction patients has not been reported. In the present study, we investigated the dynamic changes of serum bFGF in 30 patients with acute cerebral infarction and found that serum bFGF increased significantly after cerebral infarction compared with the control group (p < 0.05). Serum bFGF peaked on day 3 (15.46 +/- 5.58 pg/ml; p < 0.01) and remained significantly elevated on day 14 following cerebral infarction. In this study, it was also found that the levels of bFGF with large infarction were higher at each time point than those with moderate or small infarction (p < 0.05). There was a positive correlation between the peak level of bFGF and improvement of clinical neurological deficits scored by Scandinavian Stroke Scale (SSS) (r = 0.596; p < 0.05). These results suggest that the serum bFGF level increased significantly after cerebral infarction and the level of serum bFGF could be of value to estimate the infarction size and clinical prognosis. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000234281800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66407
Appears in Collections:北京大学第二临床医学院_神经内科_期刊论文

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作者单位: 1.Fuxing Hosp, Dept Neurol, Beijing 100045, Peoples R China
2.Shougang Hosp, Dept Neurol, Beijing 100041, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China

Recommended Citation:
Guo, HL,Huang, L,Cheng, M,et al. Serial measurement of serum basic fibroblast growth factor in patients with acute cerebral infarction[J]. NEUROSCIENCE LETTERS,2006,393(1):56-59.
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