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学科主题临床医学
Serial measurement of serum basic fibroblast growth factor in patients with acute cerebral infarction
Guo, HL; Huang, L; Cheng, M; Jin, X; Zhao, YF; Yi, M
关键词cerebral infarction brain ischemia stroke basic fibroblast growth factor infarction size Scandinavian Stroke Scale
刊名NEUROSCIENCE LETTERS
2006-01-23
DOI10.1016/j.neulet.2005.09.043
393期:1页:56-59
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]HIPPOCAMPAL-NEURONS ; ISCHEMIC-STROKE ; NERVOUS-SYSTEM ; ANGIOGENESIS ; MODEL ; RAT ; EXPRESSION ; INDUCTION ; HEPARIN ; HYPOXIA
英文摘要

Basic fibroblast growth factor (bFGF) has been reported to be involved in the pathophysiological changes following cerebral infarction. Basic fibroblast growth factor is upregulated in the brain and conduces to neuroprotection and angiogenesis in experimental brain ischemia, but the change of serum bFGF in cerebral infarction patients has not been reported. In the present study, we investigated the dynamic changes of serum bFGF in 30 patients with acute cerebral infarction and found that serum bFGF increased significantly after cerebral infarction compared with the control group (p < 0.05). Serum bFGF peaked on day 3 (15.46 +/- 5.58 pg/ml; p < 0.01) and remained significantly elevated on day 14 following cerebral infarction. In this study, it was also found that the levels of bFGF with large infarction were higher at each time point than those with moderate or small infarction (p < 0.05). There was a positive correlation between the peak level of bFGF and improvement of clinical neurological deficits scored by Scandinavian Stroke Scale (SSS) (r = 0.596; p < 0.05). These results suggest that the serum bFGF level increased significantly after cerebral infarction and the level of serum bFGF could be of value to estimate the infarction size and clinical prognosis. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000234281800012
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66407
专题北京大学第二临床医学院_神经内科
作者单位1.Fuxing Hosp, Dept Neurol, Beijing 100045, Peoples R China
2.Shougang Hosp, Dept Neurol, Beijing 100041, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Guo, HL,Huang, L,Cheng, M,et al. Serial measurement of serum basic fibroblast growth factor in patients with acute cerebral infarction[J]. NEUROSCIENCE LETTERS,2006,393(1):56-59.
APA Guo, HL,Huang, L,Cheng, M,Jin, X,Zhao, YF,&Yi, M.(2006).Serial measurement of serum basic fibroblast growth factor in patients with acute cerebral infarction.NEUROSCIENCE LETTERS,393(1),56-59.
MLA Guo, HL,et al."Serial measurement of serum basic fibroblast growth factor in patients with acute cerebral infarction".NEUROSCIENCE LETTERS 393.1(2006):56-59.
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