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学科主题: 临床医学
题名:
The role of pathogenic B-cell clones in antibody mediated autoimmune disorders
作者: Wang, J; Zhu, XJ
关键词: autoimmune ; B-cell ; pathogenesis ; treatment
刊名: JOURNAL OF DERMATOLOGICAL SCIENCE
发表日期: 2004-12-01
DOI: 10.1016/j.jdermsci.2004.07.004
卷: 36, 期:3, 页:141-148
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: SYSTEMIC-LUPUS-ERYTHEMATOSUS ; PARANEOPLASTIC PEMPHIGUS ; RHEUMATOID-ARTHRITIS ; INFLAMMATORY DISEASES ; IMMUNOGLOBULIN ; MECHANISMS ; THERAPY ; AUTOANTIBODY ; IMMUNE ; IMMUNOTHERAPY
英文摘要:

Our understanding of the rote of B-cells in the immunopathogenesis of certain antibody mediated diseases has developed remarkably in the past few years. In this review, autoantibody mediated immune disorders associated with pathogenic B-cell clones are discussed. We have focused on the roles and pathogenic mechanisms of B-cell clones in autoantibodyimmune diseases. The roles of pathogenic B-cells in Castleman′s disease in PNP patients is used as one example. The developments in the treatment of B-cell, mediated autoimmune diseases, such as intravenous immunoglobulin (IVIg), targets the regulatory pathway of B-cells, using anti-CD20, CD19, CD22 and, CD95 monoclonal antibody therapy, etc. are also discussed. Immunotherapy, targeting specific pathogenic B-cells, is believed to be one approach in the management of autoimmune diseases. (C) 2004 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. AR rights reserved.

语种: 英语
WOS记录号: WOS:000225756800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66413
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China

Recommended Citation:
Wang, J,Zhu, XJ. The role of pathogenic B-cell clones in antibody mediated autoimmune disorders[J]. JOURNAL OF DERMATOLOGICAL SCIENCE,2004,36(3):141-148.
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