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Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies
Deng, Yan1,2; Wang, Chi Chiu1; Choy, Kwong Wai1,2; Du, Quan3; Chen, Jiao1; Wang, Qin4; Li, Lu1; Chung, Tony Kwok Hung1; Tang, Tao1,2
关键词RNA interference Gene-silencing RNAi delivery Therapeutics
刊名GENE
2014-04-01
DOI10.1016/j.gene.2013.12.019
538期:2页:217-227
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]CATIONIC LIPOSOME REAGENT ; LIPID-LIKE MATERIALS ; DOUBLE-STRANDED-RNA ; HEPATITIS-C VIRUS ; IN-VIVO ; SIRNA DELIVERY ; MAMMALIAN-CELLS ; CANCER-THERAPY ; MULTIDRUG-RESISTANCE ; NONVIRAL DELIVERY
英文摘要

During recent decades there have been remarkable advances in biology, in which one of the most important discoveries is RNA interference (RNAi). RNAi is a specific post-transcriptional regulatory pathway that can result in silencing gene functions. Efforts have been done to translate this new discovery into clinical applications for disease treatment. However, technical difficulties restrict the development of RNAi, including stability, off-target effects, immunostimulation and delivery problems. Researchers have attempted to surmount these barriers and improve the bioavailability and safety of RNAi-based therapeutics by optimizing the chemistry and structure of these molecules. This paper aimed to describe the principles of RNA interference, review the therapeutic potential in various diseases and discuss the new strategies for in vivo delivery of RNAi to overcome the challenges. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000333789000002
项目编号UIM/230 ; JCYJ20120619153045369
资助机构Innovation and Technology Fund of the Hong Kong Special Administrative Region, China ; Basic Research for Shenzhen Municipal Science and Technology Programme
引用统计
被引频次:118[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66418
专题北京大学药学院
作者单位1.Chinese Univ Hong Kong, Fac Med, Dept Obstet & Gynaecol, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Shenzhen Res Inst, Hong Kong, Hong Kong, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
4.Linyi City Peoples Hosp, Div Med, Dist Nursing Off, Linyi, Peoples R China
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GB/T 7714
Deng, Yan,Wang, Chi Chiu,Choy, Kwong Wai,et al. Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies[J]. GENE,2014,538(2):217-227.
APA Deng, Yan.,Wang, Chi Chiu.,Choy, Kwong Wai.,Du, Quan.,Chen, Jiao.,...&Tang, Tao.(2014).Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies.GENE,538(2),217-227.
MLA Deng, Yan,et al."Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies".GENE 538.2(2014):217-227.
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