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学科主题: 药学
题名:
Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies
作者: Deng, Yan1,2; Wang, Chi Chiu1; Choy, Kwong Wai1,2; Du, Quan3; Chen, Jiao1; Wang, Qin4; Li, Lu1; Chung, Tony Kwok Hung1; Tang, Tao1,2
关键词: RNA interference ; Gene-silencing ; RNAi delivery ; Therapeutics
刊名: GENE
发表日期: 2014-04-01
DOI: 10.1016/j.gene.2013.12.019
卷: 538, 期:2, 页:217-227
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: CATIONIC LIPOSOME REAGENT ; LIPID-LIKE MATERIALS ; DOUBLE-STRANDED-RNA ; HEPATITIS-C VIRUS ; IN-VIVO ; SIRNA DELIVERY ; MAMMALIAN-CELLS ; CANCER-THERAPY ; MULTIDRUG-RESISTANCE ; NONVIRAL DELIVERY
英文摘要:

During recent decades there have been remarkable advances in biology, in which one of the most important discoveries is RNA interference (RNAi). RNAi is a specific post-transcriptional regulatory pathway that can result in silencing gene functions. Efforts have been done to translate this new discovery into clinical applications for disease treatment. However, technical difficulties restrict the development of RNAi, including stability, off-target effects, immunostimulation and delivery problems. Researchers have attempted to surmount these barriers and improve the bioavailability and safety of RNAi-based therapeutics by optimizing the chemistry and structure of these molecules. This paper aimed to describe the principles of RNA interference, review the therapeutic potential in various diseases and discuss the new strategies for in vivo delivery of RNAi to overcome the challenges. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: UIM/230 ; JCYJ20120619153045369
项目资助者: Innovation and Technology Fund of the Hong Kong Special Administrative Region, China ; Basic Research for Shenzhen Municipal Science and Technology Programme
WOS记录号: WOS:000333789000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66418
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Chinese Univ Hong Kong, Fac Med, Dept Obstet & Gynaecol, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Shenzhen Res Inst, Hong Kong, Hong Kong, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
4.Linyi City Peoples Hosp, Div Med, Dist Nursing Off, Linyi, Peoples R China

Recommended Citation:
Deng, Yan,Wang, Chi Chiu,Choy, Kwong Wai,et al. Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies[J]. GENE,2014,538(2):217-227.
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