|Tuberculosis burden in China: a high prevalence of pulmonary tuberculosis in household contacts with and without symptoms|
|Jia, Zhongwei1,2; Cheng, Shiming3; Ma, Yan4; Zhang, Tianhao5; Bai, Liqiong6; Xu, Weiguo7; He, Xiaoxin5; Zhang, Peiru8; Zhao, Jinkou7; Christiani, David C.9|
|关键词||Tuberculosis Household contact Index cases|
|刊名||BMC INFECTIOUS DISEASES|
|WOS标题词||Science & Technology|
Background: In the context of decreasing tuberculosis prevalence in China, we examined the effectiveness of screening household contacts of tuberculosis patients.
Methods: A tuberculosis survey was conducted in 2008. All 3,355 household contacts of notified tuberculosis cases were examined with a questionnaire interview, chest X-ray and three sputum smear tests. The effectiveness was examined by comparing the prevalence of pulmonary tuberculosis in household contacts with or without presenting clinical symptoms against the respective notification rates. Regression models were used to evaluate the factors associated with pulmonary tuberculosis.
Results: Of the 3,355 household contacts, 92 members (2.7%) had pulmonary tuberculosis, among which 46 cases were asymptomatic. The prevalence of pulmonary tuberculosis and smear positive cases in household contacts without symptoms were 20 and 7 times higher than the notification rates in 2008, while those in household contacts with symptoms were 247 and 108 times higher than notification rates, respectively. The patients detected were mainly Index Cases′ spouses, sisters/brothers and those who were in contact with female Index Cases.
Conclusions: The present study provides convincing evidence that household contacts of notified tuberculosis cases are at higher risk of developing tuberculosis. Routine screening for household contacts without any symptoms is recommended for sustained tuberculosis control in China as well as in the world.
|资助机构||National Nature Science Foundation ; Takemi Fellowship Program in Harvard School of Public Health|
|作者单位||1.Sichuan Ctr Dis Control & Prevent, Chengdu 610041, Peoples R China|
2.Beijing Res Inst TB Control, Beijing 100035, Peoples R China
3.Hunan Inst TB Control, Changsha 410013, Hunan, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
5.Harvard Univ, Sch Publ Hlth, Dept Global Hlth & Populat, Takemi Program Int Hlth, Boston, MA 02115 USA
6.Chinese Ctr Dis Control & Prevent, Natl Ctr TB Control & Prevent, Beijing 100017, Peoples R China
7.Beijing TB & Thorac Tumor Res Inst, Ctr Off, Beijing 101149, Peoples R China
8.Jiangsu Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China
9.Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
|Jia, Zhongwei,Cheng, Shiming,Ma, Yan,et al. Tuberculosis burden in China: a high prevalence of pulmonary tuberculosis in household contacts with and without symptoms[J]. BMC INFECTIOUS DISEASES,2014,14.|
|APA||Jia, Zhongwei.,Cheng, Shiming.,Ma, Yan.,Zhang, Tianhao.,Bai, Liqiong.,...&Christiani, David C..(2014).Tuberculosis burden in China: a high prevalence of pulmonary tuberculosis in household contacts with and without symptoms.BMC INFECTIOUS DISEASES,14.|
|MLA||Jia, Zhongwei,et al."Tuberculosis burden in China: a high prevalence of pulmonary tuberculosis in household contacts with and without symptoms".BMC INFECTIOUS DISEASES 14(2014).|