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Tuberculosis burden in China: a high prevalence of pulmonary tuberculosis in household contacts with and without symptoms
Jia, Zhongwei1,2; Cheng, Shiming3; Ma, Yan4; Zhang, Tianhao5; Bai, Liqiong6; Xu, Weiguo7; He, Xiaoxin5; Zhang, Peiru8; Zhao, Jinkou7; Christiani, David C.9
关键词Tuberculosis Household contact Index cases
刊名BMC INFECTIOUS DISEASES
2014-02-06
DOI10.1186/1471-2334-14-64
14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
英文摘要

Background: In the context of decreasing tuberculosis prevalence in China, we examined the effectiveness of screening household contacts of tuberculosis patients.

Methods: A tuberculosis survey was conducted in 2008. All 3,355 household contacts of notified tuberculosis cases were examined with a questionnaire interview, chest X-ray and three sputum smear tests. The effectiveness was examined by comparing the prevalence of pulmonary tuberculosis in household contacts with or without presenting clinical symptoms against the respective notification rates. Regression models were used to evaluate the factors associated with pulmonary tuberculosis.

Results: Of the 3,355 household contacts, 92 members (2.7%) had pulmonary tuberculosis, among which 46 cases were asymptomatic. The prevalence of pulmonary tuberculosis and smear positive cases in household contacts without symptoms were 20 and 7 times higher than the notification rates in 2008, while those in household contacts with symptoms were 247 and 108 times higher than notification rates, respectively. The patients detected were mainly Index Cases′ spouses, sisters/brothers and those who were in contact with female Index Cases.

Conclusions: The present study provides convincing evidence that household contacts of notified tuberculosis cases are at higher risk of developing tuberculosis. Routine screening for household contacts without any symptoms is recommended for sustained tuberculosis control in China as well as in the world.

语种英语
WOS记录号WOS:000331207500003
项目编号81372958
资助机构National Nature Science Foundation ; Takemi Fellowship Program in Harvard School of Public Health
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66419
专题中国药物依赖性研究所
作者单位1.Sichuan Ctr Dis Control & Prevent, Chengdu 610041, Peoples R China
2.Beijing Res Inst TB Control, Beijing 100035, Peoples R China
3.Hunan Inst TB Control, Changsha 410013, Hunan, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
5.Harvard Univ, Sch Publ Hlth, Dept Global Hlth & Populat, Takemi Program Int Hlth, Boston, MA 02115 USA
6.Chinese Ctr Dis Control & Prevent, Natl Ctr TB Control & Prevent, Beijing 100017, Peoples R China
7.Beijing TB & Thorac Tumor Res Inst, Ctr Off, Beijing 101149, Peoples R China
8.Jiangsu Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China
9.Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
推荐引用方式
GB/T 7714
Jia, Zhongwei,Cheng, Shiming,Ma, Yan,et al. Tuberculosis burden in China: a high prevalence of pulmonary tuberculosis in household contacts with and without symptoms[J]. BMC INFECTIOUS DISEASES,2014,14.
APA Jia, Zhongwei.,Cheng, Shiming.,Ma, Yan.,Zhang, Tianhao.,Bai, Liqiong.,...&Christiani, David C..(2014).Tuberculosis burden in China: a high prevalence of pulmonary tuberculosis in household contacts with and without symptoms.BMC INFECTIOUS DISEASES,14.
MLA Jia, Zhongwei,et al."Tuberculosis burden in China: a high prevalence of pulmonary tuberculosis in household contacts with and without symptoms".BMC INFECTIOUS DISEASES 14(2014).
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