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学科主题: 药物依赖
题名:
Tuberculosis burden in China: a high prevalence of pulmonary tuberculosis in household contacts with and without symptoms
作者: Jia, Zhongwei1,2; Cheng, Shiming3; Ma, Yan4; Zhang, Tianhao5; Bai, Liqiong6; Xu, Weiguo7; He, Xiaoxin5; Zhang, Peiru8; Zhao, Jinkou7; Christiani, David C.9
关键词: Tuberculosis ; Household contact ; Index cases
刊名: BMC INFECTIOUS DISEASES
发表日期: 2014-02-06
DOI: 10.1186/1471-2334-14-64
卷: 14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
英文摘要:

Background: In the context of decreasing tuberculosis prevalence in China, we examined the effectiveness of screening household contacts of tuberculosis patients.

Methods: A tuberculosis survey was conducted in 2008. All 3,355 household contacts of notified tuberculosis cases were examined with a questionnaire interview, chest X-ray and three sputum smear tests. The effectiveness was examined by comparing the prevalence of pulmonary tuberculosis in household contacts with or without presenting clinical symptoms against the respective notification rates. Regression models were used to evaluate the factors associated with pulmonary tuberculosis.

Results: Of the 3,355 household contacts, 92 members (2.7%) had pulmonary tuberculosis, among which 46 cases were asymptomatic. The prevalence of pulmonary tuberculosis and smear positive cases in household contacts without symptoms were 20 and 7 times higher than the notification rates in 2008, while those in household contacts with symptoms were 247 and 108 times higher than notification rates, respectively. The patients detected were mainly Index Cases′ spouses, sisters/brothers and those who were in contact with female Index Cases.

Conclusions: The present study provides convincing evidence that household contacts of notified tuberculosis cases are at higher risk of developing tuberculosis. Routine screening for household contacts without any symptoms is recommended for sustained tuberculosis control in China as well as in the world.

语种: 英语
所属项目编号: 81372958
项目资助者: National Nature Science Foundation ; Takemi Fellowship Program in Harvard School of Public Health
WOS记录号: WOS:000331207500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66419
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Sichuan Ctr Dis Control & Prevent, Chengdu 610041, Peoples R China
2.Beijing Res Inst TB Control, Beijing 100035, Peoples R China
3.Hunan Inst TB Control, Changsha 410013, Hunan, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
5.Harvard Univ, Sch Publ Hlth, Dept Global Hlth & Populat, Takemi Program Int Hlth, Boston, MA 02115 USA
6.Chinese Ctr Dis Control & Prevent, Natl Ctr TB Control & Prevent, Beijing 100017, Peoples R China
7.Beijing TB & Thorac Tumor Res Inst, Ctr Off, Beijing 101149, Peoples R China
8.Jiangsu Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China
9.Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA

Recommended Citation:
Jia, Zhongwei,Cheng, Shiming,Ma, Yan,et al. Tuberculosis burden in China: a high prevalence of pulmonary tuberculosis in household contacts with and without symptoms[J]. BMC INFECTIOUS DISEASES,2014,14.
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