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学科主题: 基础医学
题名:
Overexpression of CD133 promotes the phosphorylation of Erk in U87MG human glioblastoma cells
作者: Dong, Lin1; Qi, Nan2; Ge, Rui-Min1; Cao, Cui-Li3; Lan, Feng1; Shen, Li1
关键词: CD 133 ; Erk ; Cancer stem cell ; Signal pathway ; Proliferation ; Migration
刊名: NEUROSCIENCE LETTERS
发表日期: 2010-11-05
DOI: 10.1016/j.neulet.2010.08.057
卷: 484, 期:3, 页:210-214
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CANCER STEM-CELLS ; HEPATOCELLULAR-CARCINOMA CELLS ; MARKER CD133 ; IDENTIFICATION ; KINASES ; POPULATION ; RESISTANCE ; STRESS ; SRC
英文摘要:

An increasing number of studies support the presence of stem-like cells in human malignancies. These cells are primarily responsible for tumor initiation and thus considered as a potential target to eradicate tumors. CD133 has been identified as an important cell surface marker to enrich the stem-like population in various human tumors. However, the biological function of CD133 protein remains unknown. In this study, we observed no significant effects on cell proliferation and migration in CD133 overexpressed U87MG human glioblastoma cells. It is reported that MAPK/Erk was constitutively activated in CD133 positive liver cancer stem cell. To find out possible mechanism between CD133 and Erk phosphorylation, we performed this study to evaluate the level of Erk phosphorylation in CD133 overexpressed U87MG cells. We found that CD133 overexpression significantly activated Erk, which suggested CD133 involved in activation of MAPK/Erk pathway. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009ZX09103-733 ; 2009ZX09301-010
项目资助者: Ministry of Science and Technology of China
WOS记录号: WOS:000282998400011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66421
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100191, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 1, Dept Oncol, Dalian 116011, Liaoning, Peoples R China
3.Hebei Med Univ, Inst Basic Med, Neurobiol Lab, Shijiazhuang 050017, Hebei, Peoples R China

Recommended Citation:
Dong, Lin,Qi, Nan,Ge, Rui-Min,et al. Overexpression of CD133 promotes the phosphorylation of Erk in U87MG human glioblastoma cells[J]. NEUROSCIENCE LETTERS,2010,484(3):210-214.
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