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学科主题基础医学
Overexpression of CD133 promotes the phosphorylation of Erk in U87MG human glioblastoma cells
Dong, Lin1; Qi, Nan2; Ge, Rui-Min1; Cao, Cui-Li3; Lan, Feng1; Shen, Li1
关键词CD 133 Erk Cancer stem cell Signal pathway Proliferation Migration
刊名NEUROSCIENCE LETTERS
2010-11-05
DOI10.1016/j.neulet.2010.08.057
484期:3页:210-214
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CANCER STEM-CELLS ; HEPATOCELLULAR-CARCINOMA CELLS ; MARKER CD133 ; IDENTIFICATION ; KINASES ; POPULATION ; RESISTANCE ; STRESS ; SRC
英文摘要

An increasing number of studies support the presence of stem-like cells in human malignancies. These cells are primarily responsible for tumor initiation and thus considered as a potential target to eradicate tumors. CD133 has been identified as an important cell surface marker to enrich the stem-like population in various human tumors. However, the biological function of CD133 protein remains unknown. In this study, we observed no significant effects on cell proliferation and migration in CD133 overexpressed U87MG human glioblastoma cells. It is reported that MAPK/Erk was constitutively activated in CD133 positive liver cancer stem cell. To find out possible mechanism between CD133 and Erk phosphorylation, we performed this study to evaluate the level of Erk phosphorylation in CD133 overexpressed U87MG cells. We found that CD133 overexpression significantly activated Erk, which suggested CD133 involved in activation of MAPK/Erk pathway. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000282998400011
项目编号2009ZX09103-733 ; 2009ZX09301-010
资助机构Ministry of Science and Technology of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66421
专题北京大学基础医学院_细胞生物学系
北京大学基础医学院
北京大学临床肿瘤学院_肿瘤放疗科
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100191, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 1, Dept Oncol, Dalian 116011, Liaoning, Peoples R China
3.Hebei Med Univ, Inst Basic Med, Neurobiol Lab, Shijiazhuang 050017, Hebei, Peoples R China
推荐引用方式
GB/T 7714
Dong, Lin,Qi, Nan,Ge, Rui-Min,et al. Overexpression of CD133 promotes the phosphorylation of Erk in U87MG human glioblastoma cells[J]. NEUROSCIENCE LETTERS,2010,484(3):210-214.
APA Dong, Lin,Qi, Nan,Ge, Rui-Min,Cao, Cui-Li,Lan, Feng,&Shen, Li.(2010).Overexpression of CD133 promotes the phosphorylation of Erk in U87MG human glioblastoma cells.NEUROSCIENCE LETTERS,484(3),210-214.
MLA Dong, Lin,et al."Overexpression of CD133 promotes the phosphorylation of Erk in U87MG human glioblastoma cells".NEUROSCIENCE LETTERS 484.3(2010):210-214.
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