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学科主题: 药学
题名:
Preparation and characteristics of oridonin-loaded nanostructured lipid carriers as a controlled-release delivery system
作者: Dai, Wenting1; Zhang, Dianrui1; Duan, Cunxian1; Jia, Lejiao1; Wang, Yancai1; Feng, Feifei1; Zhang, Qiang2
关键词: Oridonin ; nanostructured lipid carriers (NLC) ; emulsion-evaporation and low temperature-solidification technique ; drug entrapment efficiency ; in vitro release
刊名: JOURNAL OF MICROENCAPSULATION
发表日期: 2010-05-01
DOI: 10.3109/02652040903079526
卷: 27, 期:3, 页:234-241
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]: SOLVENT DIFFUSION METHOD ; PHYSICOCHEMICAL CHARACTERIZATION ; AQUEOUS SYSTEM ; NANOPARTICLES ; MIXTURES ; NLC
英文摘要:

In order to improve drug entrapment efficiency and loading capacity, nanostructured lipid carriers consisting of solid lipid and liquid lipid as a new type of colloidal drug delivery system were prepared. The dispersions of oridonin-loaded solid lipid nanoparticles and nanostructured lipid carriers were successfully prepared by the emulsion-evaporation and low temperature-solidification technique using monostearin as the solid lipid, caprylic/capric triglycerides as the liquid lipid and oridonin as the model drug. Their physicochemical properties of oridonin-loaded nanostructured lipid carriers and release behaviours were investigated and compared with those of solid lipid nanoparticles. As a result, the mean particle size was similar to 200 nm with narrow polydispersity index lower than 0.4 for all developed formulations. Zeta potential values were in the range -35 mV similar to -50 mV, providing good physical stability of all formulations. The differential scanning calorimetry and X-ray diffraction analysis results demonstrated lipid nanoparticles exhibited crystal order disturbance and thus left more space to accommodate drug molecules. The improved drug entrapment efficiency and loading capacity were observed for nanostructured lipid carriers and they enhanced with increasing the caprylic/capric triglycerides content. In vitro drug release experiments exhibited biphasic drug release patterns with burst release initially and prolonged release afterwards. These results indicated that nanostructured lipid carriers could potentially be exploited as a delivery system with improved drug entrapment efficiency and controlled drug release.

语种: 英语
所属项目编号: 2009CB930 300 ; 30472130
项目资助者: National Basic Research Program of China (973 Program) ; National Nature Science Foundation of China
WOS记录号: WOS:000276867000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66426
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

Recommended Citation:
Dai, Wenting,Zhang, Dianrui,Duan, Cunxian,et al. Preparation and characteristics of oridonin-loaded nanostructured lipid carriers as a controlled-release delivery system[J]. JOURNAL OF MICROENCAPSULATION,2010,27(3):234-241.
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