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Preparation and characteristics of oridonin-loaded nanostructured lipid carriers as a controlled-release delivery system
Dai, Wenting1; Zhang, Dianrui1; Duan, Cunxian1; Jia, Lejiao1; Wang, Yancai1; Feng, Feifei1; Zhang, Qiang2
关键词Oridonin nanostructured lipid carriers (NLC) emulsion-evaporation and low temperature-solidification technique drug entrapment efficiency in vitro release
刊名JOURNAL OF MICROENCAPSULATION
2010-05-01
DOI10.3109/02652040903079526
27期:3页:234-241
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Engineering, Chemical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Engineering ; Pharmacology & Pharmacy
关键词[WOS]SOLVENT DIFFUSION METHOD ; PHYSICOCHEMICAL CHARACTERIZATION ; AQUEOUS SYSTEM ; NANOPARTICLES ; MIXTURES ; NLC
英文摘要

In order to improve drug entrapment efficiency and loading capacity, nanostructured lipid carriers consisting of solid lipid and liquid lipid as a new type of colloidal drug delivery system were prepared. The dispersions of oridonin-loaded solid lipid nanoparticles and nanostructured lipid carriers were successfully prepared by the emulsion-evaporation and low temperature-solidification technique using monostearin as the solid lipid, caprylic/capric triglycerides as the liquid lipid and oridonin as the model drug. Their physicochemical properties of oridonin-loaded nanostructured lipid carriers and release behaviours were investigated and compared with those of solid lipid nanoparticles. As a result, the mean particle size was similar to 200 nm with narrow polydispersity index lower than 0.4 for all developed formulations. Zeta potential values were in the range -35 mV similar to -50 mV, providing good physical stability of all formulations. The differential scanning calorimetry and X-ray diffraction analysis results demonstrated lipid nanoparticles exhibited crystal order disturbance and thus left more space to accommodate drug molecules. The improved drug entrapment efficiency and loading capacity were observed for nanostructured lipid carriers and they enhanced with increasing the caprylic/capric triglycerides content. In vitro drug release experiments exhibited biphasic drug release patterns with burst release initially and prolonged release afterwards. These results indicated that nanostructured lipid carriers could potentially be exploited as a delivery system with improved drug entrapment efficiency and controlled drug release.

语种英语
WOS记录号WOS:000276867000006
项目编号2009CB930 300 ; 30472130
资助机构National Basic Research Program of China (973 Program) ; National Nature Science Foundation of China
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66426
专题北京大学药学院
作者单位1.Shandong Univ, Coll Pharm, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
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GB/T 7714
Dai, Wenting,Zhang, Dianrui,Duan, Cunxian,et al. Preparation and characteristics of oridonin-loaded nanostructured lipid carriers as a controlled-release delivery system[J]. JOURNAL OF MICROENCAPSULATION,2010,27(3):234-241.
APA Dai, Wenting.,Zhang, Dianrui.,Duan, Cunxian.,Jia, Lejiao.,Wang, Yancai.,...&Zhang, Qiang.(2010).Preparation and characteristics of oridonin-loaded nanostructured lipid carriers as a controlled-release delivery system.JOURNAL OF MICROENCAPSULATION,27(3),234-241.
MLA Dai, Wenting,et al."Preparation and characteristics of oridonin-loaded nanostructured lipid carriers as a controlled-release delivery system".JOURNAL OF MICROENCAPSULATION 27.3(2010):234-241.
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