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学科主题: 药学
题名:
In vitro and in vivo evaluation of riccardin D nanosuspensions with different particle size
作者: Liu, Guangpu1; Zhang, Dianrui1; Jiao, Yang2; Guo, Hejian1; Zheng, Dandan1; Jia, Lejiao1; Duan, Cunxian1; Liu, Yue1; Tian, Xiaona1; Shen, Jingyi1; Li, Caiyun1; Zhang, Qiang3; Lou, Hongxiang2
关键词: Riccardin D ; Nanosuspensions ; Nanocrystal ; Pharmacokinetics ; Tissue distribution
刊名: COLLOIDS AND SURFACES B-BIOINTERFACES
发表日期: 2013-02-01
DOI: 10.1016/j.colsurfb.2012.09.006
卷: 102, 页:620-626
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
研究领域[WOS]: Biophysics ; Chemistry ; Materials Science
关键词[WOS]: TISSUE DISTRIBUTION ; BODY DISTRIBUTION ; BIFENDATE NANOSUSPENSIONS ; MACROCYCLIC BISBIBENZYL ; LIPID NANOPARTICLES ; IV INJECTION ; DELIVERY ; MICE ; DRUGS ; PHARMACOKINETICS
英文摘要:

Riccardin D (RD) is a novel compound extracted from Chinese liverwort Marchantia polymorpha L. It exhibits various anticancer activities and can be used during lung cancer treatment. However, the compound′s low solubility hinders its development. Recently nanosuspension has been developed as one of the most promising formulations for poorly water-soluble drugs. In order to understand the dissolution behavior of riccardin D in vitro and in vivo, two nanosuspensions of riccardin D with markedly different sizes were prepared. The particle size of nanosuspension A prepared by bottom-up method was 184.1 +/- 3.15 nm, while that of nanosuspension B prepared by top-down method was 815.4 +/- 9.65 nm. The main purpose of this study was to investigate the effects of particle size on pharmacokinetics and tissue distribution after intravenous administration. Riccardin D dissolving in organic solution was studied as control group. In pharmacokinetics study in Wistar rats, nanosuspension A showed properties similar to the control group, while nanosuspension B exhibited rather different properties. In tissue distribution research on Kunming strain mice, nanosuspension A had a multi-peak phenomenon because of reticulate endothelial system (RES) while nanosuspension B showed a high uptake in RES organs that passively target to the lungs. In conclusion, particle size of riccardin D nanosuspensions had obvious effects on pharmacokinetics and tissue distribution. (c) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: ZX09102-127 ; 2009CB930300
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China ; National Basic Research Program of China (973 Program)
WOS记录号: WOS:000313301200088
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66427
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Peoples R China
2.Shandong Univ, Sch Pharmaceut Sci, Dept Nat Prod Chem, Jinan 250012, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Guangpu,Zhang, Dianrui,Jiao, Yang,et al. In vitro and in vivo evaluation of riccardin D nanosuspensions with different particle size[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2013,102:620-626.
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