IR@PKUHSC  > 北京大学第二临床医学院  > 骨关节科
学科主题临床医学
Nucleus pulposus cells derived IGF-1 and MCP-1 enhance osteoclastogenesis and vertebrae disruption in lumbar disc herniation
Zhu, Zhongjiao1,6; Huang, Peng2; Chong, Yanxue1; George, Suraj K.3; Wen, Bingtao1; Han, Na4; Liu, Zhiqiang5; Kang, Lixin1; Lin, Nie6
关键词Lumbar disc herniation vertebra disruption IGF-1 MCP-1 osteoclast
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2014
7期:12页:8520-U810
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
研究领域[WOS]Oncology ; Pathology
关键词[WOS]GROWTH-FACTOR-I ; LOW-BACK-PAIN ; KAPPA-B LIGAND ; INTERVERTEBRAL DISC ; INFLAMMATORY CYTOKINES ; RECEPTOR ACTIVATOR ; BONE-RESORPTION ; DIFFERENTIATION ; DEGENERATION ; EXPRESSION
英文摘要

Study design: Chronic strained lumbar disc herniation (LDH) cases were classified into bulging LDH, herniated LDH and prolapse LDH types according to imaging examination, and vertebrae disruptions were evaluated. Cytokines derived from the nucleus pulposus cells were detected, and their effects on osteoclastogenesis, as well as the mechanisms involved, were studied via an in vitro osteoclast differentiation system. Objective: To clarify the mechanisms of lumbar vertebrae resorption induced by lumbar herniation. Summary and background data: Chronic strained lumbar disc herniation induced vertebrae erosion exacerbates quality of patients′ life and clinical outcome. Although nucleus pulposus cells derived cytokines were reported to play an important role in this pathogenesis, the fundamental mechanisms underlying this process are still unclear. Methods: Chronic strained lumbar disc herniation patients were diagnosed with CT scan and T2-weighted magnetic resonance imaging. RNA was extracted from 192 surgical specimens of the herniated lumbar disc and 29 surgical excisions of the lumbar disc from spinal injury patients. The expressions of osteoclastogenesis related cytokines and chemokines were examined using real time PCR. Monocytes were induced into osteoclast with M-CSF and RANKL in vitro, while the IGF-1 and MCP-1 were added into the differentiation procedure in order to evaluate the effects and explore the molecular mechanisms. Results: Vertebrae erosion had a positive relationship with lumbar disc herniation severity types. In all of the osteoclastogenesis related cytokines, the IGF-1 and MCP-1 were the most highly expressed in the nucleus pulposus cells. IGF-1 enhances activation of NF-kappa B signaling directly, but MCP-1 upregulated the expression of RANK, so that enhanced cellular sensitivity to RANKL resulted in increasing osteoclastogenesis and activity. Conclusion: Lumbar herniation induced overexpression of IGF-1 and MCP-1 in nucleus pulposus cells aggravated vertebral erosions. Hence, this study suggests that targeting osteoclastogenesis related cytokines has potential clinical significance in the treatment of lumbar disc herniation patients.

语种英语
WOS记录号WOS:000348345900020
项目编号7113170
资助机构Beijing Natural Science Foundation
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66436
专题北京大学第二临床医学院_骨关节科
作者单位1.Peking Univ, Peoples Hosp, Dept Orthoped, Beijing 100029, Peoples R China
2.Tengzhou Cent Peoples Hosp, Dept Orthoped, Tengzhou 277500, Shandong, Peoples R China
3.Tengzhou Hosp Tradit Chinese Med, Dept Emergency, Tengzhou 277500, Shandong, Peoples R China
4.Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77054 USA
5.Univ Texas MD Anderson Canc Ctr, Ctr Canc Immunol Res, Div Med, Houston, TX 77054 USA
6.Shandong Univ, Qilu Hosp, Dept Orthoped, Jinan 250012, Shandong, Peoples R China
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GB/T 7714
Zhu, Zhongjiao,Huang, Peng,Chong, Yanxue,et al. Nucleus pulposus cells derived IGF-1 and MCP-1 enhance osteoclastogenesis and vertebrae disruption in lumbar disc herniation[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2014,7(12):8520-U810.
APA Zhu, Zhongjiao.,Huang, Peng.,Chong, Yanxue.,George, Suraj K..,Wen, Bingtao.,...&Lin, Nie.(2014).Nucleus pulposus cells derived IGF-1 and MCP-1 enhance osteoclastogenesis and vertebrae disruption in lumbar disc herniation.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,7(12),8520-U810.
MLA Zhu, Zhongjiao,et al."Nucleus pulposus cells derived IGF-1 and MCP-1 enhance osteoclastogenesis and vertebrae disruption in lumbar disc herniation".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7.12(2014):8520-U810.
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