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Interaction between actin and cisplatin or transplatin
Yang, Y; Duan, LL; Li, ZF; Zeng, HH; Wang, BH; Zhang, YM
关键词actin cisplatin transplatin H-1-NMR
刊名ACTA PHYSICO-CHIMICA SINICA
2000-12-01
DOI10.3866/PKU.WHXB20001204
16期:12页:1073-1079
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]POLYMERIZATION ; PROTEINS ; COMPLEX ; DNA
英文摘要

The interaction between actin and cisplatin or transplatin has been studied by using the H-1-NMR spectra and measuring the critical concentration of actin polymerization. These studies show that both cisplatin and transplatin induce a depolymerization of F-actin, and that the effect of transplatin is more obvious than that of cisplatin at the same concentration. It is found that cisplatin promotes a polymerization of G-actin at low concentration and inhibits it at high concentration, while transplatin inhibits the polymerization at any concentration. The binding sites of cisplatin / transplatin to G-actin are discussed. It is probable that cisplatin binds with Cys-10 and Cys-285, while transplatin does not bind with Cys-10.

语种英语
WOS记录号WOS:000165931900004
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66447
专题北京大学药学院
作者单位1.Peking Univ, Inst Phys Chem, Beijing 100871, Peoples R China
2.Beijing Med Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yang, Y,Duan, LL,Li, ZF,et al. Interaction between actin and cisplatin or transplatin[J]. ACTA PHYSICO-CHIMICA SINICA,2000,16(12):1073-1079.
APA Yang, Y,Duan, LL,Li, ZF,Zeng, HH,Wang, BH,&Zhang, YM.(2000).Interaction between actin and cisplatin or transplatin.ACTA PHYSICO-CHIMICA SINICA,16(12),1073-1079.
MLA Yang, Y,et al."Interaction between actin and cisplatin or transplatin".ACTA PHYSICO-CHIMICA SINICA 16.12(2000):1073-1079.
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