北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Neuroprotective Effects of Protocatechuic Aldehyde against Neurotoxin-Induced Cellular and Animal Models of Parkinson′s Disease
作者: Zhao, Xin1,2; Zhai, Shenyu3; An, Ming-Sheng1,2; Wang, Yue-Hua2,4,5; Yang, Ying-Fan1,2; Ge, Hui-Qi1,2; Liu, Jin-Hao1,2; Pu, Xiao-Ping1,2
刊名: PLOS ONE
发表日期: 2013-10-18
DOI: 10.1371/journal.pone.0078220
卷: 8, 期:10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: MEDIUM SPINY NEURONS ; ALPHA-SYNUCLEIN ; SUBSTANTIA-NIGRA ; PC12 CELLS ; IN-VITRO ; DOPAMINERGIC-NEURONS ; COGNITIVE DECLINE ; ALZHEIMER-DISEASE ; UP-REGULATION ; DJ-1
英文摘要:

Protocatechuic aldehyde (PAL) has been reported to bind to DJ-1, a key protein involved in Parkinson′s disease (PD), and exerts potential neuroprotective effects via DJ-1 in SH-SY5Y cells. In this study, we investigated the neuroprotective pharmacological effects of PAL against neurotoxin-induced cell and animal models of PD. In cellular models of PD, PAL markedly increased cell viability rates, mitochondrial oxidation-reduction activity and mitochondrial membrane potential, and reduced intracellular ROS levels to prevent neurotoxicity in PC12 cells. In animal models of PD, PAL reduced the apomorphine injection, caused turning in 6-OHDA treated rats, and increased the motor coordination and stride decreases in MPTP treated mice. Meanwhile, in an MPTP mouse model, PAL prevented a decrease of the contents of dopamine (DA) and its metabolites in the striatum and TH-positive dopaminergic neuron loss in the substantia nigra (SN). In addition, PAL increased the protein expression of DJ-1 and reduced the level of a-synuclein in the SN of MPTP lesioned mice. PAL also increased the spine density in hippocampal CA1 neurons. The current study demonstrates that PAL can efficiently protect dopaminergic neurons against neurotoxin injury in vitro and in vivo, and that the potential mechanisms may be related to its effects in increasing DJ-1, decreasing a-synuclein and its growth-promoting effect on spine density.

语种: 英语
所属项目编号: 81202937 ; 30973889 ; 2012ZX09103201-042
项目资助者: National Natural Science Funds of China ; Significant new drugs creation Five-Year plan special science and Technology Major
WOS记录号: WOS:000326029300149
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66449
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100871, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug Sc, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100021, Peoples R China
5.Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

Recommended Citation:
Zhao, Xin,Zhai, Shenyu,An, Ming-Sheng,et al. Neuroprotective Effects of Protocatechuic Aldehyde against Neurotoxin-Induced Cellular and Animal Models of Parkinson′s Disease[J]. PLOS ONE,2013,8(10).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, Xin]'s Articles
[Zhai, Shenyu]'s Articles
[An, Ming-Sheng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, Xin]‘s Articles
[Zhai, Shenyu]‘s Articles
[An, Ming-Sheng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace