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Neuroprotective Effects of Protocatechuic Aldehyde against Neurotoxin-Induced Cellular and Animal Models of Parkinson′s Disease
Zhao, Xin1,2; Zhai, Shenyu3; An, Ming-Sheng1,2; Wang, Yue-Hua2,4,5; Yang, Ying-Fan1,2; Ge, Hui-Qi1,2; Liu, Jin-Hao1,2; Pu, Xiao-Ping1,2
刊名PLOS ONE
2013-10-18
DOI10.1371/journal.pone.0078220
8期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Natural Science Funds of China ; Significant new drugs creation Five-Year plan special science and Technology Major ; National Natural Science Funds of China ; Significant new drugs creation Five-Year plan special science and Technology Major
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]MEDIUM SPINY NEURONS ; ALPHA-SYNUCLEIN ; SUBSTANTIA-NIGRA ; PC12 CELLS ; IN-VITRO ; DOPAMINERGIC-NEURONS ; COGNITIVE DECLINE ; ALZHEIMER-DISEASE ; UP-REGULATION ; DJ-1
英文摘要

Protocatechuic aldehyde (PAL) has been reported to bind to DJ-1, a key protein involved in Parkinson′s disease (PD), and exerts potential neuroprotective effects via DJ-1 in SH-SY5Y cells. In this study, we investigated the neuroprotective pharmacological effects of PAL against neurotoxin-induced cell and animal models of PD. In cellular models of PD, PAL markedly increased cell viability rates, mitochondrial oxidation-reduction activity and mitochondrial membrane potential, and reduced intracellular ROS levels to prevent neurotoxicity in PC12 cells. In animal models of PD, PAL reduced the apomorphine injection, caused turning in 6-OHDA treated rats, and increased the motor coordination and stride decreases in MPTP treated mice. Meanwhile, in an MPTP mouse model, PAL prevented a decrease of the contents of dopamine (DA) and its metabolites in the striatum and TH-positive dopaminergic neuron loss in the substantia nigra (SN). In addition, PAL increased the protein expression of DJ-1 and reduced the level of a-synuclein in the SN of MPTP lesioned mice. PAL also increased the spine density in hippocampal CA1 neurons. The current study demonstrates that PAL can efficiently protect dopaminergic neurons against neurotoxin injury in vitro and in vivo, and that the potential mechanisms may be related to its effects in increasing DJ-1, decreasing a-synuclein and its growth-promoting effect on spine density.

语种英语
所属项目编号81202937 ; 30973889 ; 2012ZX09103201-042
资助者National Natural Science Funds of China ; Significant new drugs creation Five-Year plan special science and Technology Major ; National Natural Science Funds of China ; Significant new drugs creation Five-Year plan special science and Technology Major
WOS记录号WOS:000326029300149
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66449
专题北京大学药学院
作者单位1.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100871, Peoples R China
3.Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug Sc, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100021, Peoples R China
5.Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA
推荐引用方式
GB/T 7714
Zhao, Xin,Zhai, Shenyu,An, Ming-Sheng,et al. Neuroprotective Effects of Protocatechuic Aldehyde against Neurotoxin-Induced Cellular and Animal Models of Parkinson′s Disease[J]. PLOS ONE,2013,8(10).
APA Zhao, Xin.,Zhai, Shenyu.,An, Ming-Sheng.,Wang, Yue-Hua.,Yang, Ying-Fan.,...&Pu, Xiao-Ping.(2013).Neuroprotective Effects of Protocatechuic Aldehyde against Neurotoxin-Induced Cellular and Animal Models of Parkinson′s Disease.PLOS ONE,8(10).
MLA Zhao, Xin,et al."Neuroprotective Effects of Protocatechuic Aldehyde against Neurotoxin-Induced Cellular and Animal Models of Parkinson′s Disease".PLOS ONE 8.10(2013).
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