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学科主题: 临床医学
题名:
Recent advances in drug-antibody immunoconjugates for the treatment of cancer
作者: Lam, L; Lam, C; Li, WH; Cao, Y
刊名: DRUGS OF THE FUTURE
发表日期: 2003-09-01
卷: 28, 期:9, 页:905-910
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: METASTATIC BREAST-CANCER ; TECHNOLOGY EVALUATION ; CONJUGATE ; GELDANAMYCIN ; CARCINOMA ; LINKER ; INC
英文摘要:

Standard chemotherapy in the treatment of cancer often has a low therapeutic index due to the lack of specificity. Antibody-directed cancer chemotherapy can improve therapeutic indices, with the potential to enhance efficacy and decrease systemic toxicity. Several drug-antibody conjugates have shown impressive antitumor activity in preclinical models and are currently being evaluated in clinical trials. Drug-antibody conjugates may play a substantial role in the future as a single regimen or combination therapy in the treatment of cancer.

语种: 英语
WOS记录号: WOS:000188810400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66453
Appears in Collections:北京大学第二临床医学院_皮科_期刊论文

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作者单位: 1.BioMedSci Consulting, Unit 13A, Chicago, IL 60637 USA
2.Univ Chicago Hosp, Dept Pharmaceut Serv, Chicago, IL 60637 USA
3.Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China

Recommended Citation:
Lam, L,Lam, C,Li, WH,et al. Recent advances in drug-antibody immunoconjugates for the treatment of cancer[J]. DRUGS OF THE FUTURE,2003,28(9):905-910.
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