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A critical role of surgery in the treatment for paraneoplastic pemphigus caused by localized Castleman′s disease
Fang, Yujiang1,2,3; Zhao, Lei4; Yan, Feng4; Cui, Xijun5; Xia, Yue6; Duren, Alicia1
关键词Castleman&prime s disease Paraneoplastic pemphigus Surgical treatment
刊名MEDICAL ONCOLOGY
2010-09-01
DOI10.1007/s12032-009-9304-y
27期:3页:907-911
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]INTERLEUKIN-6 ; NEOPLASIA ; VULGARIS
英文摘要

Paraneoplastic pemphigus (PNP) is an autoimmune mucocutaneous disease associated with lympho-proliferative tumors, and sometimes with a very rare tumor, Castleman′s disease (CD). PNP can present as a variety of dermatological diseases, and so far, only limited studies of PNP caused by CD have been reported, resulting in its higher possibility of misdiagnosis. Because of the variability of clinical presentation of PNP caused by CD, selection of the appropriate therapeutic approach remains unclear. To investigate the efficacy of surgery to patients with PNP caused by localized CD, the clinical, laboratory and pathological data of 5 patients with PNP caused by localized CD, 3 females and 2 males, aged 34 years (ranging from 29 to 42), with the tumor size from 6 x 4 x 4 cm(3) to 8 x 8 x 7 cm(3), located in the mediastinum (n = 3) and retroperitoneum (n = 2), were compared before and after surgery. All patients underwent surgery, and the diagnosis was confirmed by pathological examination. Surgery significantly improved mucosal lesions, cured skin lesions and decreased serum pemphigus autoantibody 6 months after surgery. Most patients were followed up for 6-48 months, and they all had no clinical or radiological recurrence and remain disease free. Therefore, surgery is an effective approach to cure patients with PNP caused by localized CD.

语种英语
WOS记录号WOS:000281522400052
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66454
专题北京大学第三临床医学院_泌尿外科
作者单位1.Univ Missouri, Dept Internal Med, Columbia, MO 65212 USA
2.Peking Univ, Affiliated Hosp 3, Dept Urol, Beijing 100083, Peoples R China
3.Harry S Truman Mem Vet Hosp, Dept Vet Affairs, Res Serv, Columbia, MO 65212 USA
4.Second Affiliated Hosp, Wannan Med Coll, Dept Internal Med, Wuhu 241004, Peoples R China
5.Peoples Hosp Ningjin, Dept Surg, Ningjin 253400, Shandong, Peoples R China
6.Wuhan Univ, Renmin Hosp, Dept Urol, Wuhan 430060, Peoples R China
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GB/T 7714
Fang, Yujiang,Zhao, Lei,Yan, Feng,et al. A critical role of surgery in the treatment for paraneoplastic pemphigus caused by localized Castleman′s disease[J]. MEDICAL ONCOLOGY,2010,27(3):907-911.
APA Fang, Yujiang,Zhao, Lei,Yan, Feng,Cui, Xijun,Xia, Yue,&Duren, Alicia.(2010).A critical role of surgery in the treatment for paraneoplastic pemphigus caused by localized Castleman′s disease.MEDICAL ONCOLOGY,27(3),907-911.
MLA Fang, Yujiang,et al."A critical role of surgery in the treatment for paraneoplastic pemphigus caused by localized Castleman′s disease".MEDICAL ONCOLOGY 27.3(2010):907-911.
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