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学科主题: 临床医学
题名:
A critical role of surgery in the treatment for paraneoplastic pemphigus caused by localized Castleman′s disease
作者: Fang, Yujiang1,2,3; Zhao, Lei4; Yan, Feng4; Cui, Xijun5; Xia, Yue6; Duren, Alicia1
关键词: Castleman&prime ; s disease ; Paraneoplastic pemphigus ; Surgical treatment
刊名: MEDICAL ONCOLOGY
发表日期: 2010-09-01
DOI: 10.1007/s12032-009-9304-y
卷: 27, 期:3, 页:907-911
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: INTERLEUKIN-6 ; NEOPLASIA ; VULGARIS
英文摘要:

Paraneoplastic pemphigus (PNP) is an autoimmune mucocutaneous disease associated with lympho-proliferative tumors, and sometimes with a very rare tumor, Castleman′s disease (CD). PNP can present as a variety of dermatological diseases, and so far, only limited studies of PNP caused by CD have been reported, resulting in its higher possibility of misdiagnosis. Because of the variability of clinical presentation of PNP caused by CD, selection of the appropriate therapeutic approach remains unclear. To investigate the efficacy of surgery to patients with PNP caused by localized CD, the clinical, laboratory and pathological data of 5 patients with PNP caused by localized CD, 3 females and 2 males, aged 34 years (ranging from 29 to 42), with the tumor size from 6 x 4 x 4 cm(3) to 8 x 8 x 7 cm(3), located in the mediastinum (n = 3) and retroperitoneum (n = 2), were compared before and after surgery. All patients underwent surgery, and the diagnosis was confirmed by pathological examination. Surgery significantly improved mucosal lesions, cured skin lesions and decreased serum pemphigus autoantibody 6 months after surgery. Most patients were followed up for 6-48 months, and they all had no clinical or radiological recurrence and remain disease free. Therefore, surgery is an effective approach to cure patients with PNP caused by localized CD.

语种: 英语
WOS记录号: WOS:000281522400052
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66454
Appears in Collections:北京大学第三临床医学院_泌尿外科_期刊论文

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作者单位: 1.Univ Missouri, Dept Internal Med, Columbia, MO 65212 USA
2.Peking Univ, Affiliated Hosp 3, Dept Urol, Beijing 100083, Peoples R China
3.Harry S Truman Mem Vet Hosp, Dept Vet Affairs, Res Serv, Columbia, MO 65212 USA
4.Second Affiliated Hosp, Wannan Med Coll, Dept Internal Med, Wuhu 241004, Peoples R China
5.Peoples Hosp Ningjin, Dept Surg, Ningjin 253400, Shandong, Peoples R China
6.Wuhan Univ, Renmin Hosp, Dept Urol, Wuhan 430060, Peoples R China

Recommended Citation:
Fang, Yujiang,Zhao, Lei,Yan, Feng,et al. A critical role of surgery in the treatment for paraneoplastic pemphigus caused by localized Castleman′s disease[J]. MEDICAL ONCOLOGY,2010,27(3):907-911.
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