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学科主题: 精神卫生
题名:
The Level of Serum Brain-Derived Neurotrophic Factor Is Associated With the Therapeutic Efficacy of Modified Electroconvulsive Therapy in Chinese Patients With Depression
作者: Hu, Yongdong2,4; Yu, Xin1,3; Yang, Fude4; Si, Tianmei1,3; Wang, Weidong2; Tan, Yunlong4; Zhou, Dongfeng1,3; Wang, Huali1,3; Chen, Dachun4
关键词: modified electroconvulsive therapy ; brain-derived neurotrophic factor ; depression
刊名: JOURNAL OF ECT
发表日期: 2010-06-01
DOI: 10.1097/YCT.0b013e3181c18bbf
卷: 26, 期:2, 页:121-125
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Psychiatry
研究领域[WOS]: Behavioral Sciences ; Psychiatry
关键词[WOS]: FACTOR BDNF ; MOOD DISORDERS ; HIPPOCAMPAL BDNF ; MAJOR DEPRESSION ; RAT-BRAIN ; PLASTICITY ; DRUG ; ECT ; SEIZURES ; STIMULI
英文摘要:

Objective: To investigate the association between the level of serum brain-derived neurotrophic factor (sBDNF) and the therapeutic efficacy of modified electroconvulsive therapy (MECT) in Chinese patients with depressive disorder.

Methods: Twenty-eight patients with depressive episode and 28 healthy subjects were recruited in the current study. The sBDNF level was examined in all subjects before treatment and after a 2-week treatment with MECT in patients with depression. The severity of depression was measured according to the 17-item Hamilton Rating Scale for Depression in patients with depression.

Results: The severity of depression reduced significantly in patients with depression after a 2-week treatment with MECT (31.39 [SD, 4.65] vs 8.14 [5.52], P < 0.001). Serum BDNF level in patients with depression was significantly lower than that of the control group before treatment (5.66 [SD, 2.07] vs 9.17 [SD, 1.26] ng/mL, P < 0.001), then increased remarkably to the level of control subjects 2 weeks after MECT (7.90 [SD, 3.42] ng/mL). The increasing rate of sBDNF in patients with depression was significantly correlated with the decreasing rate of the total 17-item Hamilton Rating Scale for Depression score (r = 0.532, P = 0.004) and cluster scores of cognitive dysfunction (P = 0.018) and retardation (P = 0.048).

Conclusion: The change in sBDNF is associated with the therapeutic efficacy of MECT in Chinese patients with depression.

语种: 英语
WOS记录号: WOS:000278560200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66455
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
3.Beijing Huilongguan Hosp, Beijing, Peoples R China
4.China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China

Recommended Citation:
Hu, Yongdong,Yu, Xin,Yang, Fude,et al. The Level of Serum Brain-Derived Neurotrophic Factor Is Associated With the Therapeutic Efficacy of Modified Electroconvulsive Therapy in Chinese Patients With Depression[J]. JOURNAL OF ECT,2010,26(2):121-125.
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