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Intestinal Permeability of the Constituents from the Roots of Saposhnikovia divaricata in the Human Caco-2 Cell Monolayer Model
Zhao, Bo1,2; Yang, Xin-Bao3,4; Yang, Xiu-Wei2; Wu, Qi2; Wang, Ying2; Zhang, Lian-Xue1; Xu, Wei2
关键词Umbelliferae Saposhnikovia divaricata coumarins chromones Caco-2 cell monolayer
刊名PLANTA MEDICA
2011-09-01
DOI10.1055/s-0030-1270741
77期:13页:1531-1535
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]DECURSINOL ANGELATE
英文摘要

The bidirectional intestinal permeability of the active constituents from the roots of Saposhnikovia divaricata, including four coumarins, anomalin (1), 5-methoxy-7-(3,3-dimethylallyloxy)coumarin (2), decursin (3), and decursinol angelate (4), as well as four chromones, cimifugin (5), prim-O-glucosylcimifugin (6), 3′-O-angeloylhamaudol (7), and sec-O-glucosylhamaudol (8), was studied by using the Caco-2 cell monolayer. These compounds were assayed by HPLC, and their transport parameters, including apparent permeability coefficients (P(app)), were then calculated. The bidirectional P(app) values of the compounds were compared with those of the markers, propranolol and atenolol. Compounds 1-5 and 7 were assigned to well-absorbed compounds, while 6 and 8 were assigned to moderately absorbed compounds. The transport of 1-7 increased linearly as a function of time up to 180 min and concentration within the test range of 10-200 mu M, thus their passive diffusion mechanism was proposed. The results provided some useful information for predicting the intestinal absorption in vivo of these compounds.

语种英语
WOS记录号WOS:000294481300012
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66465
Collection北京大学药学院
作者单位1.Beijing Univ Chinese Med, Beijing, Peoples R China
2.Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
4.Xiyuan Hosp, China Acad Chinese Med Sci, Res Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Bo,Yang, Xin-Bao,Yang, Xiu-Wei,et al. Intestinal Permeability of the Constituents from the Roots of Saposhnikovia divaricata in the Human Caco-2 Cell Monolayer Model[J]. PLANTA MEDICA,2011,77(13):1531-1535.
APA Zhao, Bo.,Yang, Xin-Bao.,Yang, Xiu-Wei.,Wu, Qi.,Wang, Ying.,...&Xu, Wei.(2011).Intestinal Permeability of the Constituents from the Roots of Saposhnikovia divaricata in the Human Caco-2 Cell Monolayer Model.PLANTA MEDICA,77(13),1531-1535.
MLA Zhao, Bo,et al."Intestinal Permeability of the Constituents from the Roots of Saposhnikovia divaricata in the Human Caco-2 Cell Monolayer Model".PLANTA MEDICA 77.13(2011):1531-1535.
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