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学科主题: 药学
题名:
Intestinal Permeability of the Constituents from the Roots of Saposhnikovia divaricata in the Human Caco-2 Cell Monolayer Model
作者: Zhao, Bo1,2; Yang, Xin-Bao3,4; Yang, Xiu-Wei2; Wu, Qi2; Wang, Ying2; Zhang, Lian-Xue1; Xu, Wei2
关键词: Umbelliferae ; Saposhnikovia divaricata ; coumarins ; chromones ; Caco-2 cell monolayer
刊名: PLANTA MEDICA
发表日期: 2011-09-01
DOI: 10.1055/s-0030-1270741
卷: 77, 期:13, 页:1531-1535
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: DECURSINOL ANGELATE
英文摘要:

The bidirectional intestinal permeability of the active constituents from the roots of Saposhnikovia divaricata, including four coumarins, anomalin (1), 5-methoxy-7-(3,3-dimethylallyloxy)coumarin (2), decursin (3), and decursinol angelate (4), as well as four chromones, cimifugin (5), prim-O-glucosylcimifugin (6), 3′-O-angeloylhamaudol (7), and sec-O-glucosylhamaudol (8), was studied by using the Caco-2 cell monolayer. These compounds were assayed by HPLC, and their transport parameters, including apparent permeability coefficients (P(app)), were then calculated. The bidirectional P(app) values of the compounds were compared with those of the markers, propranolol and atenolol. Compounds 1-5 and 7 were assigned to well-absorbed compounds, while 6 and 8 were assigned to moderately absorbed compounds. The transport of 1-7 increased linearly as a function of time up to 180 min and concentration within the test range of 10-200 mu M, thus their passive diffusion mechanism was proposed. The results provided some useful information for predicting the intestinal absorption in vivo of these compounds.

语种: 英语
所属项目编号: Z0004105040311 ; 20060909-07 ; 2006BAI06A01-02 ; 2009ZX09502-006 ; 2009ZX09301-010
项目资助者: Beijing Science Foundation ; Science Foundation of Jilin Province ; National Sciences and Technology Sustain Program of China ; "Major New Medicine Project" in Mega-projects of Science Research of China
WOS记录号: WOS:000294481300012
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66465
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Beijing Univ Chinese Med, Beijing, Peoples R China
2.Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
4.Xiyuan Hosp, China Acad Chinese Med Sci, Res Ctr, Beijing, Peoples R China

Recommended Citation:
Zhao, Bo,Yang, Xin-Bao,Yang, Xiu-Wei,et al. Intestinal Permeability of the Constituents from the Roots of Saposhnikovia divaricata in the Human Caco-2 Cell Monolayer Model[J]. PLANTA MEDICA,2011,77(13):1531-1535.
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