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Cytotoxic resibufogenin transformation products from cell suspension cultures of Platycodon grandiflorum
Li, LX; Li, P; Ye, M; Zhong, L; Guo, D
关键词Platycodon grandiflorum campanulaceae resibufogenin biotransformation cell suspension cultures
刊名LETTERS IN ORGANIC CHEMISTRY
2004-04-01
1期:2页:176-178
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]CATHARANTHUS-ROSEUS ; ASPERGILLUS-NIGER ; LEUKEMIA-CELLS ; BIOTRANSFORMATION ; BUFADIENOLIDES ; ARTEMISININ ; CINOBUFAGIN
英文摘要

Four biotransformed products of resibufogenin were obtained after 4 days of incubation with cell suspension cultures of Platycodon grandiflorum. On the basis of chemical and spectral data, their structures were elucidated as 3-epi-resibufogenin. marinobufagin, 1beta-hydroxy-resibufogenin, and 3-epi-marinobufagin respectively, among which the latter two compounds are new. These compounds were found to exhibit potent cylotoxic activities against Bel-7402. BGC-823. HeLa, and HL-60 human cancer cell lines.

语种英语
WOS记录号WOS:000226121500020
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66478
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Li, LX,Li, P,Ye, M,et al. Cytotoxic resibufogenin transformation products from cell suspension cultures of Platycodon grandiflorum[J]. LETTERS IN ORGANIC CHEMISTRY,2004,1(2):176-178.
APA Li, LX,Li, P,Ye, M,Zhong, L,&Guo, D.(2004).Cytotoxic resibufogenin transformation products from cell suspension cultures of Platycodon grandiflorum.LETTERS IN ORGANIC CHEMISTRY,1(2),176-178.
MLA Li, LX,et al."Cytotoxic resibufogenin transformation products from cell suspension cultures of Platycodon grandiflorum".LETTERS IN ORGANIC CHEMISTRY 1.2(2004):176-178.
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