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学科主题: 药学
题名:
Cytotoxic resibufogenin transformation products from cell suspension cultures of Platycodon grandiflorum
作者: Li, LX; Li, P; Ye, M; Zhong, L; Guo, D
关键词: Platycodon grandiflorum ; campanulaceae ; resibufogenin ; biotransformation ; cell suspension cultures
刊名: LETTERS IN ORGANIC CHEMISTRY
发表日期: 2004-04-01
卷: 1, 期:2, 页:176-178
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: CATHARANTHUS-ROSEUS ; ASPERGILLUS-NIGER ; LEUKEMIA-CELLS ; BIOTRANSFORMATION ; BUFADIENOLIDES ; ARTEMISININ ; CINOBUFAGIN
英文摘要:

Four biotransformed products of resibufogenin were obtained after 4 days of incubation with cell suspension cultures of Platycodon grandiflorum. On the basis of chemical and spectral data, their structures were elucidated as 3-epi-resibufogenin. marinobufagin, 1beta-hydroxy-resibufogenin, and 3-epi-marinobufagin respectively, among which the latter two compounds are new. These compounds were found to exhibit potent cylotoxic activities against Bel-7402. BGC-823. HeLa, and HL-60 human cancer cell lines.

语种: 英语
WOS记录号: WOS:000226121500020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66478
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Li, LX,Li, P,Ye, M,et al. Cytotoxic resibufogenin transformation products from cell suspension cultures of Platycodon grandiflorum[J]. LETTERS IN ORGANIC CHEMISTRY,2004,1(2):176-178.
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