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Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity
Chen, Ru1; Wang, Jing1; Zhang, Yuan2; Tang, Shaowen3; Zhan, Siyan1
关键词ATDH Genetic polymorphism Drug metabolism Drug transporter Immune response Oxidative stress
刊名ARCHIVES OF TOXICOLOGY
2015-06-01
DOI10.1007/s00204-015-1473-1
89期:6页:883-897
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]INDUCED LIVER-INJURY ; MANGANESE SUPEROXIDE-DISMUTASE ; LATENT TUBERCULOSIS INFECTION ; GSTT1 GENETIC POLYMORPHISMS ; COLORECTAL-CANCER PATIENTS ; INDUCED HEPATIC-INJURY ; S-TRANSFERASE M1 ; RISK-FACTORS ; METABOLIZING-ENZYMES ; ASSOCIATION
英文摘要

Anti-tuberculosis drug-induced hepatotoxicity (ATDH) is one of the leading adverse drug reactions during the course of tuberculosis treatment and poses a considerable challenge to clinicians and researchers. Previous studies have revealed the important contribution of drug metabolism and transporter enzymes to the complexity of ATDH. The emerging roles of immune response and oxidative stress resulting from reactive metabolite in the development of ATDH have also gained attention recently. Both non-genetic and genetic factors can have a significant impact on the susceptibility to ATDH, consequently altering the risk of hepatotoxicity in susceptible individuals. Non-genetic risk factors associated with ATDH include host factors, environment factors and drug-related factors. Genetic factors contributing to the susceptibility of ATDH involve genetic variations in bioactivation/toxification pathways via the cytochrome P450 enzymes (phase I), detoxification reactions by N-acetyl transferase 2, glutathione S-transferase and uridine diphosphate glucuronosyltransferase (phase II) and hepatic transport (phase III), together with immunological factors and antioxidant response. Better understanding of these factors may help to predict and prevent the occurrence of ATDH and develop more effective treatments. This review focuses on the mechanisms of ATDH and the key factors of susceptibility associated with drug metabolism, hepatic transport, immune response and oxidative stress.

语种英语
WOS记录号WOS:000354471800005
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66483
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada
3.Nanjing Med Univ, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Chen, Ru,Wang, Jing,Zhang, Yuan,et al. Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity[J]. ARCHIVES OF TOXICOLOGY,2015,89(6):883-897.
APA Chen, Ru,Wang, Jing,Zhang, Yuan,Tang, Shaowen,&Zhan, Siyan.(2015).Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity.ARCHIVES OF TOXICOLOGY,89(6),883-897.
MLA Chen, Ru,et al."Key factors of susceptibility to anti-tuberculosis drug-induced hepatotoxicity".ARCHIVES OF TOXICOLOGY 89.6(2015):883-897.
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