北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients
作者: Zhang, Xiang Yang1,2; Chen, Da Chun2; Xiu, Mei Hong2; Wang, Fan2; Qi, Ling Yan2; Sun, Hong Qang2; Chen, Song2; He, Shu Chang3; Wu, Gui Ying; Haile, Colin N.; Kosten, Therese A.; Lu, Lin4; Kosten, Thomas R.
关键词: Schizophrenia ; Oxidative stress ; Free radical ; Thioredoxin ; Psychopathology
刊名: SCHIZOPHRENIA RESEARCH
发表日期: 2009-09-01
DOI: 10.1016/j.schres.2009.05.016
卷: 113, 期:2-3, 页:151-157
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: ATYPICAL ANTIPSYCHOTIC-DRUGS ; ANTIOXIDANT DEFENSE SYSTEM ; BLOOD SUPEROXIDE-DISMUTASE ; FREE-RADICAL PATHOLOGY ; TARDIVE-DYSKINESIA ; LIPID-PEROXIDATION ; THERAPEUTIC IMPLICATIONS ; PLASMA THIOREDOXIN ; REDOX REGULATION ; DIFFERENT FORMS
英文摘要:

Excessive free radical production leading to oxidative stress may be involved in the pathophysiology of schizophrenia. oxidative stress increases serum thioredoxin (TRX), a redox-regulating protein with antioxidant activity recognized as an oxidative-stress marker. The aim of this study was to assess the clinical significance of serum TRX levels in various stages of schizophrenia. Serum TRX levels were determined using ELISA from 60 never-medicated first-episode and 66 medicated chronic schizophrenia patients and 66 healthy control subjects matched for age and gender. The psychopathology of schizophrenia was assessed by the Positive and Negative Syndrome Scale (PANSS). Our results showed that group comparison between first-episode and chronic patients and control groups revealed significantly increased serum TRX only in first-episode patients. Increased levels of TRX in patients experiencing an acute stage schizophrenic episode was also significantly higher compared to chronic schizophrenic patients on antipsychotic medication. Serum TRX was also positively correlated with positive symptoms of schizophrenia. Our results suggest oxidative stress occurs in an acute stage of schizophrenic episode and may have an important role in pathogenesis and symptomology of schizophrenia. Lower TRX levels in chronic patients treated with antipsychotics may have implications for treatment outcome. (C) 2009 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 03T-459 ; 05T-726 ; 7072035 ; K05-DA0454 ; P50-DA18827 ; U01-MH79639
项目资助者: Stanley Medical Research Institute ; Beijing Municipal Natural Science Foundation ; Department of Veterans Affairs, VISN 16 ; Mental Illness Research, Education and Clinical Center (MIRECC) ; United States National Institute of Health
WOS记录号: WOS:000269630800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66493
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Baylor Coll Med, VA Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
2.Beijing HuiLongGuan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China
3.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Xiang Yang,Chen, Da Chun,Xiu, Mei Hong,et al. The novel oxidative stress marker thioredoxin is increased in first-episode schizophrenic patients[J]. SCHIZOPHRENIA RESEARCH,2009,113(2-3):151-157.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Xiang Yang]'s Articles
[Chen, Da Chun]'s Articles
[Xiu, Mei Hong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Xiang Yang]‘s Articles
[Chen, Da Chun]‘s Articles
[Xiu, Mei Hong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace