|Status of non-steroidal anti-inflammatory drugs use and its association with chronic kidney disease: A cross-sectional survey in China|
|Pan, Yujing; Zhang, Luxia; Wang, Fang; Li, Xiaomei; Wang, Haiyan; China Natl Survey Chronic Kidney D|
|关键词||chronic kidney disease cross-sectional study non-steroidal anti-inflammatory drugs|
|WOS标题词||Science & Technology|
|类目[WOS]||Urology & Nephrology|
|研究领域[WOS]||Urology & Nephrology|
|关键词[WOS]||CHRONIC RENAL-DISEASE ; ANALGESIC USE ; UNITED-STATES ; PHENACETIN ; MORTALITY ; ABUSE ; ACETAMINOPHEN ; ASPIRIN ; RISK ; POPULATION|
AimNon-steroidal anti-inflammatory drugs (NSAIDs) have been reported to be associated with adverse effects including kidney injury, while relevant studies from developing countries are limited. We aimed to explore the status of NSAIDs use in China, as well as cross-sectional association between NSAIDs intake and presence of chronic kidney disease (CKD).
MethodsA national representative sample of 47204 adults in China was used. Prevalence of regular NSAIDs use was reported. Age- and sex- matched controls of NSAIDs users were then selected. The association between NSAIDs use and kidney injury were analyzed using logistic regression.
ResultsAltogether 1129 participants reported regular use of NSAIDs, with the adjusted prevalence of 3.6% (95% CI, 3.2%-3.9%). And 76.9% of them (n=868) had taken phenacetin-containing analgesics, with an adjusted prevalence of 3.2% (95% CI, 2.9%-3.5%). After adjusting for potential confounders, long-term NSAIDs intake (48 months) was associated with eGFR< 60mL/min per 1.73m(2), with an OR of 2.36 (95% CI, 1.28-4.37).
ConclusionRegular use of NSAIDs, especially phenacetin-containing drugs, is prevalent in China. And long-term NSAIDs intake (48 months) was independently associated with reduced renal function.
Summary at a Glance Cross-sectional analyses of NSAID use and the incidence of CKD in a large Chinese population. 3.6% reported regular NSAID intake, of which 76% were taking phenacetin containing analgesics. Long term NSAID use was associated with an OR 2.36 (95%CI 1.28-4.37) of CKD with an eGFR < 60mL/min per 1.73m(2).
|项目编号||2007BAI04B10 ; 201002010 ; 2011BAI10B01 ; D131100004713007|
|资助机构||National Key Technology Research & ; Development Program during the 11th Five-Year Period from the Ministry of Science and Technology of the People&prime ; s Republic of China ; Research Special Fund for Public Welfare Industry of Health from National Health and Family Planning Commission of the People&prime ; s Republic of China ; National Key Technology R& ; D Program of the Ministry of Science and Technology ; Beijing Science and Technology Committee|
|作者单位||1.Peking Univ, Hosp 1, Inst Nephrol, Dept Med,Renal Div,Key Lab Renal Dis,Minist Hlth, Beijing 100034, Peoples R China|
2.Peking Univ, Key Lab Chron Kidney Dis Prevent & Treatment, Minist Educ, Beijing 100034, Peoples R China
|Pan, Yujing,Zhang, Luxia,Wang, Fang,et al. Status of non-steroidal anti-inflammatory drugs use and its association with chronic kidney disease: A cross-sectional survey in China[J]. NEPHROLOGY,2014,19(10):655-660.|
|APA||Pan, Yujing,Zhang, Luxia,Wang, Fang,Li, Xiaomei,Wang, Haiyan,&China Natl Survey Chronic Kidney D.(2014).Status of non-steroidal anti-inflammatory drugs use and its association with chronic kidney disease: A cross-sectional survey in China.NEPHROLOGY,19(10),655-660.|
|MLA||Pan, Yujing,et al."Status of non-steroidal anti-inflammatory drugs use and its association with chronic kidney disease: A cross-sectional survey in China".NEPHROLOGY 19.10(2014):655-660.|