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Status of non-steroidal anti-inflammatory drugs use and its association with chronic kidney disease: A cross-sectional survey in China
Pan, Yujing; Zhang, Luxia; Wang, Fang; Li, Xiaomei; Wang, Haiyan; China Natl Survey Chronic Kidney D
关键词chronic kidney disease cross-sectional study non-steroidal anti-inflammatory drugs
刊名NEPHROLOGY
2014-10-01
DOI10.1111/nep.12318
19期:10页:655-660
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]CHRONIC RENAL-DISEASE ; ANALGESIC USE ; UNITED-STATES ; PHENACETIN ; MORTALITY ; ABUSE ; ACETAMINOPHEN ; ASPIRIN ; RISK ; POPULATION
英文摘要

AimNon-steroidal anti-inflammatory drugs (NSAIDs) have been reported to be associated with adverse effects including kidney injury, while relevant studies from developing countries are limited. We aimed to explore the status of NSAIDs use in China, as well as cross-sectional association between NSAIDs intake and presence of chronic kidney disease (CKD).

MethodsA national representative sample of 47204 adults in China was used. Prevalence of regular NSAIDs use was reported. Age- and sex- matched controls of NSAIDs users were then selected. The association between NSAIDs use and kidney injury were analyzed using logistic regression.

ResultsAltogether 1129 participants reported regular use of NSAIDs, with the adjusted prevalence of 3.6% (95% CI, 3.2%-3.9%). And 76.9% of them (n=868) had taken phenacetin-containing analgesics, with an adjusted prevalence of 3.2% (95% CI, 2.9%-3.5%). After adjusting for potential confounders, long-term NSAIDs intake (48 months) was associated with eGFR< 60mL/min per 1.73m(2), with an OR of 2.36 (95% CI, 1.28-4.37).

ConclusionRegular use of NSAIDs, especially phenacetin-containing drugs, is prevalent in China. And long-term NSAIDs intake (48 months) was independently associated with reduced renal function.

Summary at a Glance Cross-sectional analyses of NSAID use and the incidence of CKD in a large Chinese population. 3.6% reported regular NSAID intake, of which 76% were taking phenacetin containing analgesics. Long term NSAID use was associated with an OR 2.36 (95%CI 1.28-4.37) of CKD with an eGFR < 60mL/min per 1.73m(2).

语种英语
WOS记录号WOS:000342745100010
项目编号2007BAI04B10 ; 201002010 ; 2011BAI10B01 ; D131100004713007
资助机构National Key Technology Research &amp ; Development Program during the 11th Five-Year Period from the Ministry of Science and Technology of the People&prime ; s Republic of China ; Research Special Fund for Public Welfare Industry of Health from National Health and Family Planning Commission of the People&prime ; s Republic of China ; National Key Technology R&amp ; D Program of the Ministry of Science and Technology ; Beijing Science and Technology Committee
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66495
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Inst Nephrol, Dept Med,Renal Div,Key Lab Renal Dis,Minist Hlth, Beijing 100034, Peoples R China
2.Peking Univ, Key Lab Chron Kidney Dis Prevent & Treatment, Minist Educ, Beijing 100034, Peoples R China
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GB/T 7714
Pan, Yujing,Zhang, Luxia,Wang, Fang,et al. Status of non-steroidal anti-inflammatory drugs use and its association with chronic kidney disease: A cross-sectional survey in China[J]. NEPHROLOGY,2014,19(10):655-660.
APA Pan, Yujing,Zhang, Luxia,Wang, Fang,Li, Xiaomei,Wang, Haiyan,&China Natl Survey Chronic Kidney D.(2014).Status of non-steroidal anti-inflammatory drugs use and its association with chronic kidney disease: A cross-sectional survey in China.NEPHROLOGY,19(10),655-660.
MLA Pan, Yujing,et al."Status of non-steroidal anti-inflammatory drugs use and its association with chronic kidney disease: A cross-sectional survey in China".NEPHROLOGY 19.10(2014):655-660.
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