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学科主题药学
Synthesis of a spacer-armed disulfated tetrasaccharide of SB1a, a carbohydrate hapten associated with human hepatocellular carcinoma
Li, Q; Li, H; Li, Q; Lou, QH; Su, B; Cai, MS; Li, ZJ
关键词SB1a HCC carbohydrate antigen disulfated tetrasaccharide synthesis
刊名CARBOHYDRATE RESEARCH
2002-11-19
337期:21-23页:1929-1934
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]MONOCLONAL-ANTIBODIES ; HEXASACCHARIDE
英文摘要

A disulfated tetrasaccharide fragment with a spacer arm of human hepatocellular carcinoma carbohydrate antigen SB1a, namely, 2-aminoethyl 3-O-sulfo-beta-D-galactopyranosyl-(1 --> 3)-2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1 --> 4)-3-O-sulfo-beta-D-galactopyranosyl-(1 --> 4)-beta-D-glucopyranoside was synthesized via a [2 + 1 + 1] block building mode. In the last coupling step toward the trisaccharide acceptor 8, benzoyl protected galactosyl bromide donor 14 was found to be much more reactive than the acetyl-protected donors. (C) 2002 Elsevier Science Ltd. All rights reserved.

语种英语
WOS记录号WOS:000179425500003
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66498
Collection北京大学药学院_化学生物学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Li, Q,Li, H,Li, Q,et al. Synthesis of a spacer-armed disulfated tetrasaccharide of SB1a, a carbohydrate hapten associated with human hepatocellular carcinoma[J]. CARBOHYDRATE RESEARCH,2002,337(21-23):1929-1934.
APA Li, Q.,Li, H.,Li, Q.,Lou, QH.,Su, B.,...&Li, ZJ.(2002).Synthesis of a spacer-armed disulfated tetrasaccharide of SB1a, a carbohydrate hapten associated with human hepatocellular carcinoma.CARBOHYDRATE RESEARCH,337(21-23),1929-1934.
MLA Li, Q,et al."Synthesis of a spacer-armed disulfated tetrasaccharide of SB1a, a carbohydrate hapten associated with human hepatocellular carcinoma".CARBOHYDRATE RESEARCH 337.21-23(2002):1929-1934.
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