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学科主题: 基础医学
题名:
Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase accumulation
作者: Plate, Markus; Li, Ting; Wang, Yu; Mo, Xiaoning; Zhang, Yingmei; Ma, Dalong; Han, Wenling
关键词: apoptosis ; cell cycle ; cell growth ; CMTM4 ; MARVEL
刊名: MOLECULES AND CELLS
发表日期: 2010-04-01
DOI: 10.1007/s10059-010-0038-7
卷: 29, 期:4, 页:355-361
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: CHEMOKINE-LIKE FACTOR-1 ; MOLECULAR-CLONING ; SEQUENCES ; RECEPTOR ; PROTEIN ; CANCER ; TESTIS
英文摘要:

Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly expressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an important gene involved in cell growth and cell cycle regulation.

语种: 英语
所属项目编号: 2006AA02A305 ; NCET-07-0013 ; 30571691
项目资助者: Chinese High Tech Program (863) ; Program for New Century Excellent Talents in University ; National Natural Science Foundation
WOS记录号: WOS:000277244500006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66500
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: Peking Univ, Ctr Human Dis Genom, Dept Immunol, Hlth Sci Ctr,Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Plate, Markus,Li, Ting,Wang, Yu,et al. Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through Inducing G2/M phase accumulation[J]. MOLECULES AND CELLS,2010,29(4):355-361.
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