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学科主题口腔医学
Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B
Pacios, Sandra1; Xiao, Wenmei1,2; Mattos, Marcelo1; Lim, Jason1; Tarapore, Rohinton S.1; Alsadun, Sarah1; Yu, Bo3; Wang, Cun-Yu3; Graves, Dana T.1
刊名SCIENTIFIC REPORTS
2015-12-15
DOI10.1038/srep16694
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Institutes of Health (NIH) ; Penn Center for Musculoskeletal Disorders ; National Institutes of Health (NIH) ; Penn Center for Musculoskeletal Disorders
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]RANKL ; OSTEOCLASTOGENESIS ; DIFFERENTIATION ; PATHOGENESIS ; HOMEOSTASIS ; RESORPTION ; APOPTOSIS ; DISEASE ; NFATC1 ; LIGAND
英文摘要

Bacterial pathogens stimulate periodontitis, the most common osteolytic disease in humans and the most common cause of tooth loss in adults. Previous studies identified leukocytes and their products as key factors in this process. We demonstrate for the first time that osteoblast lineage cells play a critical role in periodontal disease. Oral infection stimulated nuclear localization of NF-kappa B in osteoblasts and osteocytes in the periodontium of wild type but not transgenic mice that expressed a lineage specific dominant negative mutant of IKK (IKK-DN) in osteoblast lineage cells. Wild-type mice were also susceptible to bacteria induced periodontal bone loss but transgenic mice were not. The lack of bone loss in the experimental group was linked to reduced RANKL expression by osteoblast lineage cells that led to diminished osteoclast mediated bone resorption and greater coupled new bone formation. The results demonstrate that osteoblast lineage cells are key contributors to periodontal bone loss through an NF-kappa B mediated mechanism.

语种英语
所属项目编号DE-017732 ; DE-021921 ; AR-060055 ; NIH/NIAMS P30 AR050950
资助者National Institutes of Health (NIH) ; Penn Center for Musculoskeletal Disorders ; National Institutes of Health (NIH) ; Penn Center for Musculoskeletal Disorders
WOS记录号WOS:000366389400001
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66503
专题北京大学口腔医学院_牙周科
作者单位1.Univ Penn, Sch Dent Med, Dept Periodont, Philadelphia, PA 19104 USA
2.Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100871, Peoples R China
3.Univ Calif Los Angeles, Sch Dent, Div Oral Biol & Med, Los Angeles, CA 90024 USA
推荐引用方式
GB/T 7714
Pacios, Sandra,Xiao, Wenmei,Mattos, Marcelo,et al. Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B[J]. SCIENTIFIC REPORTS,2015,5.
APA Pacios, Sandra.,Xiao, Wenmei.,Mattos, Marcelo.,Lim, Jason.,Tarapore, Rohinton S..,...&Graves, Dana T..(2015).Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B.SCIENTIFIC REPORTS,5.
MLA Pacios, Sandra,et al."Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B".SCIENTIFIC REPORTS 5(2015).
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