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学科主题: 口腔医学
题名:
Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B
作者: Pacios, Sandra1; Xiao, Wenmei1,2; Mattos, Marcelo1; Lim, Jason1; Tarapore, Rohinton S.1; Alsadun, Sarah1; Yu, Bo3; Wang, Cun-Yu3; Graves, Dana T.1
刊名: SCIENTIFIC REPORTS
发表日期: 2015-12-15
DOI: 10.1038/srep16694
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: RANKL ; OSTEOCLASTOGENESIS ; DIFFERENTIATION ; PATHOGENESIS ; HOMEOSTASIS ; RESORPTION ; APOPTOSIS ; DISEASE ; NFATC1 ; LIGAND
英文摘要:

Bacterial pathogens stimulate periodontitis, the most common osteolytic disease in humans and the most common cause of tooth loss in adults. Previous studies identified leukocytes and their products as key factors in this process. We demonstrate for the first time that osteoblast lineage cells play a critical role in periodontal disease. Oral infection stimulated nuclear localization of NF-kappa B in osteoblasts and osteocytes in the periodontium of wild type but not transgenic mice that expressed a lineage specific dominant negative mutant of IKK (IKK-DN) in osteoblast lineage cells. Wild-type mice were also susceptible to bacteria induced periodontal bone loss but transgenic mice were not. The lack of bone loss in the experimental group was linked to reduced RANKL expression by osteoblast lineage cells that led to diminished osteoclast mediated bone resorption and greater coupled new bone formation. The results demonstrate that osteoblast lineage cells are key contributors to periodontal bone loss through an NF-kappa B mediated mechanism.

语种: 英语
所属项目编号: DE-017732 ; DE-021921 ; AR-060055 ; NIH/NIAMS P30 AR050950
项目资助者: National Institutes of Health (NIH) ; Penn Center for Musculoskeletal Disorders
WOS记录号: WOS:000366389400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66503
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Univ Penn, Sch Dent Med, Dept Periodont, Philadelphia, PA 19104 USA
2.Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, Beijing 100871, Peoples R China
3.Univ Calif Los Angeles, Sch Dent, Div Oral Biol & Med, Los Angeles, CA 90024 USA

Recommended Citation:
Pacios, Sandra,Xiao, Wenmei,Mattos, Marcelo,et al. Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B[J]. SCIENTIFIC REPORTS,2015,5.
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