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Microbial transformation of dehydrocostuslactone and costunolide by Mucor polymorphosporus and Aspergillus candidus
Ma, Xiao-Chi; Zheng, Han; Guo, De-An
关键词dehydrocostuslactone costunolide biotransformation mucor polymorphosporus Aspergillus candidus
刊名ENZYME AND MICROBIAL TECHNOLOGY
2007-04-03
40期:5页:1013-1019
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]ARTEMISIA-HERBA-ALBA ; SESQUITERPENE LACTONES ; BIOTRANSFORMATIONS ; EPOXIDES
英文摘要

Twenty strains of filamentous fungi (from nine genera) and four species of bacteria were screened for their capabilities to transform dehydrocostuslactone (1) and costunolide (10). Stereo- and region-specific hydroxylation, epoxidation and hydrogenation reactions of the substrates by Mucor polymorphosporus AS 3.3443 and Aspergillus candidus CICC 2360 were reported. Twelve transformed products were obtained and their structures were identified on the basis of their spectral data. Among them, 10 alpha,14 beta-epoxy-11 alpha, 13-dihydrodehydrocostuslactone and 10 alpha,14-dihydroxy-11 alpha, 13-dihydrodeliydrocostuslactone are new compounds. The biotransformation kinetics were also investigated. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000245519000004
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66505
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Natl Inst Control Biol & Pharmaceut Prod, Beijing 100050, Peoples R China
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Ma, Xiao-Chi,Zheng, Han,Guo, De-An. Microbial transformation of dehydrocostuslactone and costunolide by Mucor polymorphosporus and Aspergillus candidus[J]. ENZYME AND MICROBIAL TECHNOLOGY,2007,40(5):1013-1019.
APA Ma, Xiao-Chi,Zheng, Han,&Guo, De-An.(2007).Microbial transformation of dehydrocostuslactone and costunolide by Mucor polymorphosporus and Aspergillus candidus.ENZYME AND MICROBIAL TECHNOLOGY,40(5),1013-1019.
MLA Ma, Xiao-Chi,et al."Microbial transformation of dehydrocostuslactone and costunolide by Mucor polymorphosporus and Aspergillus candidus".ENZYME AND MICROBIAL TECHNOLOGY 40.5(2007):1013-1019.
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