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Biological Effects of Osteoblast-Like Cells on Nanohydroxyapatite Particles at a Low Concentration Range
Liu, Xiaochen1; Wei, Jie1,2; Wei, Shicheng1,3
刊名JOURNAL OF NANOMATERIALS
2011
DOI10.1155/2011/104747
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
资助者State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University ; State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]HYDROXYAPATITE NANOPARTICLES ; IN-VITRO ; PROLIFERATION ; NANO ; APOPTOSIS ; CRYSTALS ; SIZE
英文摘要

The biological effects of osteoblast-like MG-63 cells on nanohydroxyapatite (n-HA) at the low concentration range (5-25 mu g/mL) for 5 days was investigated. The results showed the viability and actin cytoskeleton of the cells descended with the increase of the concentration of n-HA, and the actin cytoskeleton of cells was depolymerised and became more disordered. Apoptotic rate of cells (1.85%, 1.99%, and 2.29%) increased with the increase of n-HA concentration (5, 15, and 25 mu g/mL) and become significantly higher than the control. Total intracellular protein content decreased with n-HA concentration increase, showing significant difference between 25 mu g/mL and the control, and no significant change of ALP activity was observed at the 5th day. The results revealed that the cell growth was inhibited by n-HA in a concentration-dependent manner, and the obvious biological effects of MG-63 cells on n-HA existed at the low concentration range from 5 to 25 mu g/mL.

语种英语
所属项目编号2007CB936103
资助者State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University ; State Key Development Program for Basic Research of China ; Fundamental Research Funds for the Central Universities ; Peking University
WOS记录号WOS:000296804600001
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66507
专题北京大学口腔医学院
作者单位1.Peking Univ, Ctr Biomed Mat & Tissue Engn, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
2.E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China
3.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
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Liu, Xiaochen,Wei, Jie,Wei, Shicheng. Biological Effects of Osteoblast-Like Cells on Nanohydroxyapatite Particles at a Low Concentration Range[J]. JOURNAL OF NANOMATERIALS,2011.
APA Liu, Xiaochen,Wei, Jie,&Wei, Shicheng.(2011).Biological Effects of Osteoblast-Like Cells on Nanohydroxyapatite Particles at a Low Concentration Range.JOURNAL OF NANOMATERIALS.
MLA Liu, Xiaochen,et al."Biological Effects of Osteoblast-Like Cells on Nanohydroxyapatite Particles at a Low Concentration Range".JOURNAL OF NANOMATERIALS (2011).
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