IR@PKUHSC  > 北京大学第三临床医学院  > 神经内科
学科主题临床医学
STRATIFYING DISEASE STAGES WITH DIFFERENT PROGRESSION RATES DETERMINED BY ELECTROPHYSIOLOGICAL TESTS IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
Liu, Xiao-Xuan; Zhang, Jun; Zheng, Ju-Yang; Zhang, Shuo; Xu, Ying-Sheng; Kang, De-Xuan; Fan, Dong-Sheng
关键词amyotrophic lateral sclerosis forced vital capacity motor unit number estimates progression rate ALS-functional rating score compound muscle action potential amplitude
刊名MUSCLE & NERVE
2009-03-01
DOI10.1002/mus.21144
39期:3页:304-309
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]UNIT NUMBER ESTIMATE ; CLINICAL-TRIAL ; RATING-SCALE ; ALS ; SURVIVAL
英文摘要

By determining the usefulness of motor unit number estimate (MUNE) and compound muscle action potential (CMAP) amplitude in patients with amyotrophic lateral sclerosis (ALS), we tried to find an effective way to stratify the disease stages. In all, 112 consecutive ALS patients were enrolled, among whom 73 were elicited in a longitudinal study. MUNE by the standard incremental technique, the average CMAP amplitude, total Medical Research Council (MRC) score, ALS-functional rating score (ALS-FRS), Appel ALS rating scale (AARS), and forced vital capacity (FVC) were performed at baseline and months 3, 6, and 12 after study entry. We found MUNE correlated with CMAP amplitude (P < 0.01) as well as MRC score (P < 0.01) in regionally concordant distal muscles. Both MUNE and CMAP amplitude correlated significantly with ALS-FRS (P < 0.05) and AARS (P < 0.01). A MUNE decrease was observed at months 3, 6, and 12 compared with baseline, and the rate of change at month 3 was 50.47%. The decrease in MUNE over the first 3 months was significantly greater than other measurements. We arbitrarily divided the patients into three stages: (1) rapid progression: the rate of change of MUNE and CMAP amplitude during the first 3 months exceeded 50%; (2) moderate progression: the rate of change of MUNE was greater than 50% but CMAP amplitude was less than 50%; (3) slow progression: the rate of change of both MUNE and CMAP amplitude were less than 50%. Comparing the rate of ALS-FRS descent per year using one-way ANOVA showed a significant difference among the three groups (P < 0.01). Muscle Nerve 39: 304-309, 2009

语种英语
WOS记录号WOS:000263656800004
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66508
Collection北京大学第三临床医学院_神经内科
作者单位Peking Univ, Dept Neurol, Hosp 3, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xiao-Xuan,Zhang, Jun,Zheng, Ju-Yang,et al. STRATIFYING DISEASE STAGES WITH DIFFERENT PROGRESSION RATES DETERMINED BY ELECTROPHYSIOLOGICAL TESTS IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS[J]. MUSCLE &amp; NERVE,2009,39(3):304-309.
APA Liu, Xiao-Xuan.,Zhang, Jun.,Zheng, Ju-Yang.,Zhang, Shuo.,Xu, Ying-Sheng.,...&Fan, Dong-Sheng.(2009).STRATIFYING DISEASE STAGES WITH DIFFERENT PROGRESSION RATES DETERMINED BY ELECTROPHYSIOLOGICAL TESTS IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS.MUSCLE & NERVE,39(3),304-309.
MLA Liu, Xiao-Xuan,et al."STRATIFYING DISEASE STAGES WITH DIFFERENT PROGRESSION RATES DETERMINED BY ELECTROPHYSIOLOGICAL TESTS IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS".MUSCLE & NERVE 39.3(2009):304-309.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Liu, Xiao-Xuan]'s Articles
[Zhang, Jun]'s Articles
[Zheng, Ju-Yang]'s Articles
百度学术
百度学术Similar articles in
[Liu, Xiao-Xuan]'s Articles
[Zhang, Jun]'s Articles
[Zheng, Ju-Yang]'s Articles
必应学术
必应学术Similar articles in
[Liu, Xiao-Xuan]'s Articles
[Zhang, Jun]'s Articles
[Zheng, Ju-Yang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.