北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 神经内科  > 期刊论文
学科主题: 临床医学
题名:
STRATIFYING DISEASE STAGES WITH DIFFERENT PROGRESSION RATES DETERMINED BY ELECTROPHYSIOLOGICAL TESTS IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
作者: Liu, Xiao-Xuan; Zhang, Jun; Zheng, Ju-Yang; Zhang, Shuo; Xu, Ying-Sheng; Kang, De-Xuan; Fan, Dong-Sheng
关键词: amyotrophic lateral sclerosis ; forced vital capacity ; motor unit number estimates ; progression rate ; ALS-functional rating score ; compound muscle action potential amplitude
刊名: MUSCLE & NERVE
发表日期: 2009-03-01
DOI: 10.1002/mus.21144
卷: 39, 期:3, 页:304-309
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: UNIT NUMBER ESTIMATE ; CLINICAL-TRIAL ; RATING-SCALE ; ALS ; SURVIVAL
英文摘要:

By determining the usefulness of motor unit number estimate (MUNE) and compound muscle action potential (CMAP) amplitude in patients with amyotrophic lateral sclerosis (ALS), we tried to find an effective way to stratify the disease stages. In all, 112 consecutive ALS patients were enrolled, among whom 73 were elicited in a longitudinal study. MUNE by the standard incremental technique, the average CMAP amplitude, total Medical Research Council (MRC) score, ALS-functional rating score (ALS-FRS), Appel ALS rating scale (AARS), and forced vital capacity (FVC) were performed at baseline and months 3, 6, and 12 after study entry. We found MUNE correlated with CMAP amplitude (P < 0.01) as well as MRC score (P < 0.01) in regionally concordant distal muscles. Both MUNE and CMAP amplitude correlated significantly with ALS-FRS (P < 0.05) and AARS (P < 0.01). A MUNE decrease was observed at months 3, 6, and 12 compared with baseline, and the rate of change at month 3 was 50.47%. The decrease in MUNE over the first 3 months was significantly greater than other measurements. We arbitrarily divided the patients into three stages: (1) rapid progression: the rate of change of MUNE and CMAP amplitude during the first 3 months exceeded 50%; (2) moderate progression: the rate of change of MUNE was greater than 50% but CMAP amplitude was less than 50%; (3) slow progression: the rate of change of both MUNE and CMAP amplitude were less than 50%. Comparing the rate of ALS-FRS descent per year using one-way ANOVA showed a significant difference among the three groups (P < 0.01). Muscle Nerve 39: 304-309, 2009

语种: 英语
WOS记录号: WOS:000263656800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66508
Appears in Collections:北京大学第三临床医学院_神经内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Dept Neurol, Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Xiao-Xuan,Zhang, Jun,Zheng, Ju-Yang,et al. STRATIFYING DISEASE STAGES WITH DIFFERENT PROGRESSION RATES DETERMINED BY ELECTROPHYSIOLOGICAL TESTS IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS[J]. MUSCLE &amp; NERVE,2009,39(3):304-309.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Xiao-Xuan]'s Articles
[Zhang, Jun]'s Articles
[Zheng, Ju-Yang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Xiao-Xuan]‘s Articles
[Zhang, Jun]‘s Articles
[Zheng, Ju-Yang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace