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学科主题药学
Computer-Aided Drug Design for AMP-Activated Protein Kinase Activators
Wang, Zhanli2; Huo, Jianxin2; Sun, Lidan1; Wang, Yongfu2; Jin, Hongwei1; Yu, Hui3; Zhang, Liangren1; Zhou, Lishe2
关键词AMP-activated protein kinase activator structure-based drug design ligand-based drug design fragment-based drug design structural analysis
刊名CURRENT COMPUTER-AIDED DRUG DESIGN
2011-09-01
7期:3页:214-227
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Computer Science, Interdisciplinary Applications
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Pharmacology & Pharmacy ; Computer Science
关键词[WOS]ISOLATED RAT HEPATOCYTES ; COENZYME-A REDUCTASE ; TYROSINE KINASE ; SKELETAL-MUSCLE ; SIGNALING PATHWAYS ; GLUCOSE-UPTAKE ; HEPATIC GLUCONEOGENESIS ; METABOLIC SYNDROME ; FLAVONOID ANALOGS ; STRUCTURAL BASIS
英文摘要

AMP-activated protein kinase (AMPK) is an important therapeutic target for the potential treatment of metabolic disorders, cardiovascular disease and cancer. Recently, various classes of compounds that activate AMPK by direct or indirect interactions have been reported. The importance of computer-aided drug design approaches in the search for potent activators of AMPK is now established, including structure-based design, ligand-based design, fragment-based design, as well as structural analysis. This review article highlights the computer-aided drug design approaches utilized to discover of activators targeting AMPK. The principles, advantages or limitation of the different methods are also being discussed together with examples of applications taken from the literatures.

语种英语
所属项目编号20902068
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000295412900007
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66509
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Baotou Med Coll, Affiliated Hosp 1, Cent Expt Lab, Baotou 014010, Peoples R China
3.Tongji Univ, Affiliated Peoples Hosp 10, Dept Lab Med, Shanghai 200072, Peoples R China
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GB/T 7714
Wang, Zhanli,Huo, Jianxin,Sun, Lidan,et al. Computer-Aided Drug Design for AMP-Activated Protein Kinase Activators[J]. CURRENT COMPUTER-AIDED DRUG DESIGN,2011,7(3):214-227.
APA Wang, Zhanli.,Huo, Jianxin.,Sun, Lidan.,Wang, Yongfu.,Jin, Hongwei.,...&Zhou, Lishe.(2011).Computer-Aided Drug Design for AMP-Activated Protein Kinase Activators.CURRENT COMPUTER-AIDED DRUG DESIGN,7(3),214-227.
MLA Wang, Zhanli,et al."Computer-Aided Drug Design for AMP-Activated Protein Kinase Activators".CURRENT COMPUTER-AIDED DRUG DESIGN 7.3(2011):214-227.
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