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学科主题基础医学
Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation
Liu, Feng-Yu1; Qu, Xiao-Xiu1; Cai, Jie1; Wang, Fa-Tian1; Xing, Guo-Gang1; Wan, You1,2,3
关键词wide dynamic range neuron spinal dorsal horn spinal nerve ligation neuropathic pain
刊名NEUROSCIENCE BULLETIN
2011-02-01
DOI10.1007/s12264-011-1039-z
27期:1页:1-8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]DORSAL-HORN NEURONS ; NR2B-CONTAINING NMDA RECEPTORS ; CENTRAL SENSITIZATION ; ELECTRICAL-STIMULATION ; PERIPHERAL NEUROPATHY ; MECHANICAL ALLODYNIA ; ECTOPIC DISCHARGES ; TACTILE ALLODYNIA ; FIELD SIZE ; CORD
英文摘要

Objective The present study aimed to investigate the electrophysiological properties of wide dynamic range (WDR) neurons in spinal dorsal horn of rats with neuropathic pain induced by lumber 5 (L5) spinal nerve ligation (SNL) in a large size of samples. Methods Adult Sprague-Dawley rats were divided into normal and SNL groups. Electrophysiological technique was used to record the characteristics of WDR neurons in the spinal dorsal horn. Results Compared with the WDR neurons in normal rats, the WDR neurons in SNL rats showed an increase in excitability, manifested by an enlargement of the receptive field size, an increase in the proportion of neurons that exhibited spontaneous activities, decreases in the C-response threshold and latency, and an increase in the C-response duration. In addition, the numbers of A(beta)- and C-fiber-evoked discharges were smaller in SNL rats than in normal rats. Conclusion The excitability of spinal WDR neurons increased in rats with neuropathic pain induced by L5 SNL. The increase in excitability of WDR neurons may contribute to the development of neuropathic pain.

语种英语
WOS记录号WOS:000295726900001
项目编号30600173 ; 81070893 ; 109003 ; 2007CB512501
资助机构National Natural Science Foundation of China ; China Ministry of Education ; National Basic Research Development Program (973 Program) of China ; Beijing Municipal Commission of Education
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被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66516
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
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GB/T 7714
Liu, Feng-Yu,Qu, Xiao-Xiu,Cai, Jie,et al. Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation[J]. NEUROSCIENCE BULLETIN,2011,27(1):1-8.
APA Liu, Feng-Yu,Qu, Xiao-Xiu,Cai, Jie,Wang, Fa-Tian,Xing, Guo-Gang,&Wan, You.(2011).Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation.NEUROSCIENCE BULLETIN,27(1),1-8.
MLA Liu, Feng-Yu,et al."Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation".NEUROSCIENCE BULLETIN 27.1(2011):1-8.
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