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学科主题: 基础医学
题名:
Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation
作者: Liu, Feng-Yu1; Qu, Xiao-Xiu1; Cai, Jie1; Wang, Fa-Tian1; Xing, Guo-Gang1; Wan, You1,2,3
关键词: wide dynamic range neuron ; spinal dorsal horn ; spinal nerve ligation ; neuropathic pain
刊名: NEUROSCIENCE BULLETIN
发表日期: 2011-02-01
DOI: 10.1007/s12264-011-1039-z
卷: 27, 期:1, 页:1-8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: DORSAL-HORN NEURONS ; NR2B-CONTAINING NMDA RECEPTORS ; CENTRAL SENSITIZATION ; ELECTRICAL-STIMULATION ; PERIPHERAL NEUROPATHY ; MECHANICAL ALLODYNIA ; ECTOPIC DISCHARGES ; TACTILE ALLODYNIA ; FIELD SIZE ; CORD
英文摘要:

Objective The present study aimed to investigate the electrophysiological properties of wide dynamic range (WDR) neurons in spinal dorsal horn of rats with neuropathic pain induced by lumber 5 (L5) spinal nerve ligation (SNL) in a large size of samples. Methods Adult Sprague-Dawley rats were divided into normal and SNL groups. Electrophysiological technique was used to record the characteristics of WDR neurons in the spinal dorsal horn. Results Compared with the WDR neurons in normal rats, the WDR neurons in SNL rats showed an increase in excitability, manifested by an enlargement of the receptive field size, an increase in the proportion of neurons that exhibited spontaneous activities, decreases in the C-response threshold and latency, and an increase in the C-response duration. In addition, the numbers of A(beta)- and C-fiber-evoked discharges were smaller in SNL rats than in normal rats. Conclusion The excitability of spinal WDR neurons increased in rats with neuropathic pain induced by L5 SNL. The increase in excitability of WDR neurons may contribute to the development of neuropathic pain.

语种: 英语
所属项目编号: 30600173 ; 81070893 ; 109003 ; 2007CB512501
项目资助者: National Natural Science Foundation of China ; China Ministry of Education ; National Basic Research Development Program (973 Program) of China ; Beijing Municipal Commission of Education
WOS记录号: WOS:000295726900001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66516
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Feng-Yu,Qu, Xiao-Xiu,Cai, Jie,et al. Electrophysiological properties of spinal wide dynamic range neurons in neuropathic pain rats following spinal nerve ligation[J]. NEUROSCIENCE BULLETIN,2011,27(1):1-8.
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