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学科主题临床医学
Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case-control study
Zhu, Yanping1; Liu, Kuo1; Tang, Xun1; Wang, Jinwei1,2; Yu, Zhiping1; Wu, Yiqun1; Chen, Dafang1; Wang, Xueyin1; Fang, Kai1; Li, Na3; Huang, Shaoping3; Hu, Yonghua1
关键词Ischemic stroke NINJ2 gene Family-based study Association Interaction
刊名JOURNAL OF THROMBOSIS AND THROMBOLYSIS
2014-11-01
DOI10.1007/s11239-014-1065-6
38期:4页:470-476
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]PROTEIN-KINASE-C ; CHROMOSOME 12P13 ; CONFERS RISK ; POPULATION ; ADHESION ; DISEASE ; CHINA ; SMOKE
英文摘要

Novel susceptibility genes related to ischemic stroke (IS) are proposed in recent literatures. Population-based replicate studies would cause false positive results due to population stratification. 229 recruit IS patients and their 229 non-IS siblings were used in this study to avoid population stratification. The family-based study was conducted in Beijing from June 2005 to June 2012. Association between SNPs and IS was found in the sibship discordant tests, and the conditional logistic regression was performed to identify effect size and explore gene-environment interactions. Significant allelic association was identified between NINJ2 gene rs11833579 (P = 0.008), protein kinase C eta gene rs2230501 (P = 0.039) and IS. The AA genotype of rs11833579 increased 1.51-fold risk (95 % CI 1.04-3.46; P = 0.043) of IS, and it conferred susceptibility to IS only in a dominant model (OR 2.69; 95 % CI 1.06-6.78; P = 0.036]. Risk of IS was higher (HR 3.58; 95 % CI 1.54-8.31; P = 0.003) especially when the carriers of rs11833579 AA genotype were smokers. The present study suggests A allele of rs11833579 may play a role in mediating susceptibility to IS and it may increase the risk of IS together with smoking.

语种英语
所属项目编号81230066 ; 30872173 ; 81102177 ; 81172744
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000343216100008
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66521
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 1, Dept Nephrol, Beijing 100871, Peoples R China
3.Fangshan Dist Bur Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Yanping,Liu, Kuo,Tang, Xun,et al. Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case-control study[J]. JOURNAL OF THROMBOSIS AND THROMBOLYSIS,2014,38(4):470-476.
APA Zhu, Yanping.,Liu, Kuo.,Tang, Xun.,Wang, Jinwei.,Yu, Zhiping.,...&Hu, Yonghua.(2014).Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case-control study.JOURNAL OF THROMBOSIS AND THROMBOLYSIS,38(4),470-476.
MLA Zhu, Yanping,et al."Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case-control study".JOURNAL OF THROMBOSIS AND THROMBOLYSIS 38.4(2014):470-476.
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