IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case-control study
Zhu, Yanping1; Liu, Kuo1; Tang, Xun1; Wang, Jinwei1,2; Yu, Zhiping1; Wu, Yiqun1; Chen, Dafang1; Wang, Xueyin1; Fang, Kai1; Li, Na3; Huang, Shaoping3; Hu, Yonghua1
关键词Ischemic stroke NINJ2 gene Family-based study Association Interaction
刊名JOURNAL OF THROMBOSIS AND THROMBOLYSIS
2014-11-01
DOI10.1007/s11239-014-1065-6
38期:4页:470-476
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]PROTEIN-KINASE-C ; CHROMOSOME 12P13 ; CONFERS RISK ; POPULATION ; ADHESION ; DISEASE ; CHINA ; SMOKE
英文摘要

Novel susceptibility genes related to ischemic stroke (IS) are proposed in recent literatures. Population-based replicate studies would cause false positive results due to population stratification. 229 recruit IS patients and their 229 non-IS siblings were used in this study to avoid population stratification. The family-based study was conducted in Beijing from June 2005 to June 2012. Association between SNPs and IS was found in the sibship discordant tests, and the conditional logistic regression was performed to identify effect size and explore gene-environment interactions. Significant allelic association was identified between NINJ2 gene rs11833579 (P = 0.008), protein kinase C eta gene rs2230501 (P = 0.039) and IS. The AA genotype of rs11833579 increased 1.51-fold risk (95 % CI 1.04-3.46; P = 0.043) of IS, and it conferred susceptibility to IS only in a dominant model (OR 2.69; 95 % CI 1.06-6.78; P = 0.036]. Risk of IS was higher (HR 3.58; 95 % CI 1.54-8.31; P = 0.003) especially when the carriers of rs11833579 AA genotype were smokers. The present study suggests A allele of rs11833579 may play a role in mediating susceptibility to IS and it may increase the risk of IS together with smoking.

语种英语
WOS记录号WOS:000343216100008
项目编号81230066 ; 30872173 ; 81102177 ; 81172744
资助机构National Natural Science Foundation of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66521
专题北京大学第一临床医学院_肾脏内科
北京大学基础医学院
北京大学公共卫生学院_流行病与卫生统计学系
北京大学公共卫生学院_公共卫生学院
北京大学临床肿瘤学院_麻醉科
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 1, Dept Nephrol, Beijing 100871, Peoples R China
3.Fangshan Dist Bur Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Yanping,Liu, Kuo,Tang, Xun,et al. Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case-control study[J]. JOURNAL OF THROMBOSIS AND THROMBOLYSIS,2014,38(4):470-476.
APA Zhu, Yanping.,Liu, Kuo.,Tang, Xun.,Wang, Jinwei.,Yu, Zhiping.,...&Hu, Yonghua.(2014).Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case-control study.JOURNAL OF THROMBOSIS AND THROMBOLYSIS,38(4),470-476.
MLA Zhu, Yanping,et al."Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case-control study".JOURNAL OF THROMBOSIS AND THROMBOLYSIS 38.4(2014):470-476.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Association between (197KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhu, Yanping]的文章
[Liu, Kuo]的文章
[Tang, Xun]的文章
百度学术
百度学术中相似的文章
[Zhu, Yanping]的文章
[Liu, Kuo]的文章
[Tang, Xun]的文章
必应学术
必应学术中相似的文章
[Zhu, Yanping]的文章
[Liu, Kuo]的文章
[Tang, Xun]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Association between NINJ2 gene polymorphisms and ischemic stroke_ a family-based case-control study.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。