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Genome plasticity and ori-ter rebalancing in Salmonella typhi
Liu, GR; Liu, WQ; Johnston, RN; Sanderson, KE; Li, SX; Liu, SL
关键词Salmonella typhi genome plasticity ori-ter rebalancing I-CeuI genome rearrangements typhoid
刊名MOLECULAR BIOLOGY AND EVOLUTION
2006-02-01
DOI10.1093/molbev/msj042
23期:2页:365-371
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
关键词[WOS]ENTERICA SEROVAR TYPHI ; DETERMINING DIVERGENCE TIMES ; ESCHERICHIA-COLI K-12 ; PHYSICAL MAP ; HOMOLOGOUS RECOMBINATION ; INSERTION-SEQUENCE ; TYPHIMURIUM LT2 ; PROTEIN CLOCK ; CLEAVAGE MAP ; IS200
英文摘要

Genome plasticity resulting from frequent rearrangement of the bacterial genome is a fascinating but poorly understood phenomenon. First reported in Salmonella typhi, it has been observed only in a small number Of Salmonella serovars, although the over 2,500 known Salmonella serovars are all very closely related. To gain insights into this phenomenon and elucidate its roles in bacterial evolution, especially those involved in the formation of particular pathogens, we systematically analyzed the genomes of 127 wild-type S. typhi strains isolated from many places of the world and compared them with the two sequenced strains, Ty2 and CT18, attempting to find possible associations between genome rearrangement and other significant genomic features. Like other host-adapted Salmonella serovars, S. typhi contained large genome insertions, including the 134 kb Salmonella pathogenicity island, SPIT Our analyses showed that SP17 disrupted the physical balance of the bacterial genome between the replication origin (ori) and terminus (ter) when this DNA segment was inserted into the genome, and rearrangement in individual strains further changed the genome balance status, with a general tendency toward a better balanced genome structure. In a given S. typhi strain, genome diversification occurred and resulted in different structures among cells in the culture. Under a stressed condition, bacterial cells with better balanced genome structures were selected to greatly increase in proportion; in such cases, bacteria with better balanced genomes formed larger colonies and grew with shorter generation times. Our results support the hypothesis that genome plasticity as a result of frequent rearrangement provides the opportunity for the bacterial genome to adopt a better balanced structure and thus eventually stabilizes the genome during evolution.

语种英语
WOS记录号WOS:000234718800014
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被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66525
专题基础医学院_病原生物学系
作者单位1.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB, Canada
2.Harbin Med Coll, Dept Microbiol, Harbin, Peoples R China
3.Univ Calgary, Dept Biol Sci, Calgary, AB, Canada
4.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
5.Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB, Canada
推荐引用方式
GB/T 7714
Liu, GR,Liu, WQ,Johnston, RN,et al. Genome plasticity and ori-ter rebalancing in Salmonella typhi[J]. MOLECULAR BIOLOGY AND EVOLUTION,2006,23(2):365-371.
APA Liu, GR,Liu, WQ,Johnston, RN,Sanderson, KE,Li, SX,&Liu, SL.(2006).Genome plasticity and ori-ter rebalancing in Salmonella typhi.MOLECULAR BIOLOGY AND EVOLUTION,23(2),365-371.
MLA Liu, GR,et al."Genome plasticity and ori-ter rebalancing in Salmonella typhi".MOLECULAR BIOLOGY AND EVOLUTION 23.2(2006):365-371.
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