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学科主题: 药学
题名:
A potential target associated with both cancer and cancer stem cells: A combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes
作者: Liu, Yang; Lu, Wan-Liang; Guo, Jia; Du, Ju; Li, Ting; Wu, Jin-Wei; Wang, Gui-Ling; Wang, Jian-Cheng; Zhang, Xuan; Zhang, Qiang
关键词: cancer stem cells ; breast cancer ; vinorelbine stealthy liposomes ; parthenolide stealthy liposomes ; side population
刊名: JOURNAL OF CONTROLLED RELEASE
发表日期: 2008-07-02
DOI: 10.1016/j.jconrel.2008.03.022
卷: 129, 期:1, 页:18-25
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: MYELOGENOUS LEUKEMIA STEM ; SIDE-POPULATION ; PROGENITOR CELLS ; LUNG-CANCER ; IN-VIVO ; CHEMOTHERAPY ; IDENTIFICATION ; CARCINOMA ; EFFICACY ; LINE
英文摘要:

The cancer stem cells play a critical role in both initiation and relapse of the cancers as they are resistant to the most of cytotoxic agents and able to proliferate indefinitely. Vinorelbine stealthy liposomes and parthenolide stealthy liposomes were developed for providing beneficial pharmacological properties and to eradicate cancer stem cells and non-stem cancer cells together by a combination therapy. Cytotoxicity and cancer stem-like cells (side population, SP) identification were performed on human breast cancer cell lines MCF-7 and MDA-MB-231. SP cells were further sorted from MCF-7 cells and characterized. Inhibitory effect was evaluated on the sorted SP and non-SP cells. Antitumor activity was evaluated on MCF-7 xenografts in nude mice. SP cells were identified with a higher percentage in MCF-7 cells (3.8%) and lower in MDA-MB-231 cells (0.6%). Both vinorelbine and parthenolide inhibited the proliferation in MCF-7 and MDA-MB-231 cells. As compared to non-SP cells, inhibitory effect of vinorelbine in the SP cells was lower while a robust inhibitory effect was observed when applying vinorelbine in combination with parthenolide. In the MCF-7 xenografts, stealthy liposomal vinorelbine plus stealthy liposomal parthenolide produced a full inhibitory effect. This combination therapy may provide a potential strategy for eradication of breast cancer by targeting cancer together with cancer stem cells. (c) 2008 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000257721100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66526
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Yang,Lu, Wan-Liang,Guo, Jia,et al. A potential target associated with both cancer and cancer stem cells: A combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes[J]. JOURNAL OF CONTROLLED RELEASE,2008,129(1):18-25.
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