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学科主题: 基础医学
题名:
Inhibitory effect of topiramate on Lewis lung carcinoma metastasis and its relation with AQP1 water channel
作者: Ma, B; Xiang, Y; Li, T; Yu, HM; Li, XJ
关键词: topiramate ; aquaporins ; tumor metastasis ; carbonic anhydrase
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2004
卷: 25, 期:1, 页:54-60
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: TRANSMEMBRANE CARBONIC-ANHYDRASES ; SOLID TUMORS ; CANCER ; CELLS ; EXPRESSION ; PH ; ANGIOGENESIS ; PROTEIN
英文摘要:

AIM: To study the effect of topiramate on tumor metastasis and its relation with aquaporin I (AQP1) water channel. METHODS: Lewis lung carcinoma metastatic model was used to determine the effect of topiramate on tumor growth and metastasis. Colorimetric estimation was used to investigate the action of topiramate on carbonic anhydrase (CA) activity. Western blotting and immunohistochemical analysis were used to study the influence of topiramate on AQP1 water channel expression in lungs or tumor tissues of mice bearing Lewis lung carcinoma. RESULTS: Treatment with topiramate (120 mg.kg(-1).d(-1), ig for 20 d) reduced the growth of primary tumor significantly (P<0.05). Its inhibitory rate of metastasis was 81.25 %. Topiramate inhibited CA activity in lungs of mice in a dose-dependent manner. Topiramate apparently decreased AQP1 protein expression and immunostaining in lungs or in tumor microvessel endothelial cells of mice. CONCLUSION: Suppression of AQP1 water channel expression may be an important pathway for the inhibitory effect of topiramate on tumor metastasis.

语种: 英语
WOS记录号: WOS:000187915700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66527
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Natl Res Inst Family Planning, Beijing 100081, Peoples R China

Recommended Citation:
Ma, B,Xiang, Y,Li, T,et al. Inhibitory effect of topiramate on Lewis lung carcinoma metastasis and its relation with AQP1 water channel[J]. ACTA PHARMACOLOGICA SINICA,2004,25(1):54-60.
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