IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Inhibitory effect of topiramate on Lewis lung carcinoma metastasis and its relation with AQP1 water channel
Ma, B; Xiang, Y; Li, T; Yu, HM; Li, XJ
关键词topiramate aquaporins tumor metastasis carbonic anhydrase
刊名ACTA PHARMACOLOGICA SINICA
2004
25期:1页:54-60
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]TRANSMEMBRANE CARBONIC-ANHYDRASES ; SOLID TUMORS ; CANCER ; CELLS ; EXPRESSION ; PH ; ANGIOGENESIS ; PROTEIN
英文摘要

AIM: To study the effect of topiramate on tumor metastasis and its relation with aquaporin I (AQP1) water channel. METHODS: Lewis lung carcinoma metastatic model was used to determine the effect of topiramate on tumor growth and metastasis. Colorimetric estimation was used to investigate the action of topiramate on carbonic anhydrase (CA) activity. Western blotting and immunohistochemical analysis were used to study the influence of topiramate on AQP1 water channel expression in lungs or tumor tissues of mice bearing Lewis lung carcinoma. RESULTS: Treatment with topiramate (120 mg.kg(-1).d(-1), ig for 20 d) reduced the growth of primary tumor significantly (P<0.05). Its inhibitory rate of metastasis was 81.25 %. Topiramate inhibited CA activity in lungs of mice in a dose-dependent manner. Topiramate apparently decreased AQP1 protein expression and immunostaining in lungs or in tumor microvessel endothelial cells of mice. CONCLUSION: Suppression of AQP1 water channel expression may be an important pathway for the inhibitory effect of topiramate on tumor metastasis.

语种英语
WOS记录号WOS:000187915700009
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66527
专题北京大学基础医学院_药理学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Natl Res Inst Family Planning, Beijing 100081, Peoples R China
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Ma, B,Xiang, Y,Li, T,et al. Inhibitory effect of topiramate on Lewis lung carcinoma metastasis and its relation with AQP1 water channel[J]. ACTA PHARMACOLOGICA SINICA,2004,25(1):54-60.
APA Ma, B,Xiang, Y,Li, T,Yu, HM,&Li, XJ.(2004).Inhibitory effect of topiramate on Lewis lung carcinoma metastasis and its relation with AQP1 water channel.ACTA PHARMACOLOGICA SINICA,25(1),54-60.
MLA Ma, B,et al."Inhibitory effect of topiramate on Lewis lung carcinoma metastasis and its relation with AQP1 water channel".ACTA PHARMACOLOGICA SINICA 25.1(2004):54-60.
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