IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心
学科主题临床医学
The protein source in embryo culture media influences birthweight: a comparative study between G1 v5 and G1-PLUS v5
Zhu, Jinliang1,2,3; Li, Ming1,2,3; Chen, Lixue1,2,3; Liu, Ping1,2,3; Qiao, Jie1,2,3
关键词protein source birthweight LGA singleton IVF
刊名HUMAN REPRODUCTION
2014-07-01
DOI10.1093/humrep/deu103
29期:7页:1387-1392
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]IN-VITRO CULTURE ; LARGE OFFSPRING SYNDROME ; PERINATAL OUTCOMES ; PREIMPLANTATION DEVELOPMENT ; ASSISTED REPRODUCTION ; SEQUENTIAL MEDIA ; GENE-EXPRESSION ; CHILDREN BORN ; SINGLE-EMBRYO ; AMINO-ACIDS
英文摘要

Does protein source or human serum albumin (HSA) in embryo culture media influence the subsequent birthweight?

A significant difference was observed in gestational age- and gender-adjusted birthweight (Z scores) and the proportion of large-for-gestational age (LGA) babies between embryos cultured in G1 v5 and those cultured in G1-PLUS v5 media.

It has been reported that the birthweights of singletons born from embryos cultured in Vitrolife are significantly higher than those cultured in the Cook group of media, and that G1-PLUS (Vitrolife, Gothenburg, Sweden) is associated with increased birth and placenta weights compared with Medicult ISMI.

This study was a retrospective analysis of neonatal birthweights, and included 1097 singletons born from fresh embryo transfer cycles at the Center for Reproductive Medicine of Peking University Third Hospital between January 2011 and August 2012. The number of singletons born from G1 v5 culture media was 489, and the number of singletons born from G1-PLUS v5 media was 608.

Patients < 40 years of age with a BMI < 30 kg/m(2) were analysed. Only data from newborns from singleton pregnancies and born alive after the 28th week of gestation were included. Patients with a vanishing twin or with pregnancy-related complications, such as diabetes and hypertension, were excluded, as were patients who received preimplantation genetic diagnosis or used donor oocytes. Multiple linear regression analysis was performed to determine the influence of individual factors on birthweights of singleton newborns. The birthweights and Z scores of singletons and LGA babies were compared between the G1 v5 and G1-PLUS v5 media groups.

The absolute birthweights for singletons resulting from G1-PLUS v5 were not different from singletons resulting from G1 v5 (3375.9 +/- 479.6 g versus 3333.2 +/- 491.6 g, respectively; P = 0.14). However the Z scores for singletons from embryos cultured in G1-PLUS v5 were significantly higher than for singletons cultured in G1 v5 (0.28 +/- 1.12 versus 0.09 +/- 1.15, respectively; P = 0.04), and more LGA babies were born from G1-PLUS v5 culture compared with G1 v5 (16.8 versus 12.1%, respectively; P = 0.03) culture. Finally, multiple linear regression analysis suggested that female weight (P = 0.00), male height (P = 0.04), gestational age at birth (P = 0.00), infant gender (P = 0.00) and culture media (P = 0.04) all had significant effects on the birthweights of singleton newborns.

This study was limited by its retrospective design.

Our study suggests that protein source/HSA has a significant effect on birthweights of singleton newborns.

This study was funded by the National Natural Science Foundation of China for Young Scholars (81300483). The authors have no conflicts of interest to declare.

Not applicable.

语种英语
WOS记录号WOS:000338126500008
项目编号81300483
资助机构National Natural Science Foundation of China for Young Scholars
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66532
专题北京大学第三临床医学院_生殖医学中心
作者单位1.Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Reprod Med Ctr, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
3.Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Jinliang,Li, Ming,Chen, Lixue,et al. The protein source in embryo culture media influences birthweight: a comparative study between G1 v5 and G1-PLUS v5[J]. HUMAN REPRODUCTION,2014,29(7):1387-1392.
APA Zhu, Jinliang,Li, Ming,Chen, Lixue,Liu, Ping,&Qiao, Jie.(2014).The protein source in embryo culture media influences birthweight: a comparative study between G1 v5 and G1-PLUS v5.HUMAN REPRODUCTION,29(7),1387-1392.
MLA Zhu, Jinliang,et al."The protein source in embryo culture media influences birthweight: a comparative study between G1 v5 and G1-PLUS v5".HUMAN REPRODUCTION 29.7(2014):1387-1392.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhu, Jinliang]的文章
[Li, Ming]的文章
[Chen, Lixue]的文章
百度学术
百度学术中相似的文章
[Zhu, Jinliang]的文章
[Li, Ming]的文章
[Chen, Lixue]的文章
必应学术
必应学术中相似的文章
[Zhu, Jinliang]的文章
[Li, Ming]的文章
[Chen, Lixue]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。