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Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han Population
Qu, Mei; Tang, Fulei; Yue, Weihua; Ruan, Yan; Lu, Tianlan; Liu, Zhonghua; Zhang, Handi; Han, Yonghua; Zhang, Darong; Wang, Fei; Zhang, Dai
关键词case-control study SNP haplotype linkage disequilibrium.
刊名AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
2007-04-05
DOI10.1002/ajmg.b.30322
144B期:3页:266-270
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Psychiatry
研究领域[WOS]Genetics & Heredity ; Psychiatry
关键词[WOS]BIPOLAR DISORDER ; SCOTTISH POPULATION ; NEURITE OUTGROWTH ; CHROMOSOME 1Q ; LINKAGE ; TRANSLOCATION ; NUDEL ; LOCI ; COMPLEX ; PROTEIN
英文摘要

Disrupted-in-Schizophrenia-1 (DISC1) is located on 1q42.1, one of the most promising susceptibility loci in schizophrenia linkage studies. A non-synonymous genetic variation rs821616 (Ser704Cys) in DISC1, has recently been shown to be associated with schizophrenia in family-based study [Callicott et al. (2005); Proc Natl Acad Sci USA 102: 8627-8632]. In order to further confirm this issue, we examined four single nucleotide polymorphisms (SNPs) in a chromosomal region spanning 42 kb of this gene, namely rs821616, rs821597, rs4658971, and rs843979, in Chinese sample of 313 schizophrenia patients and 317 healthy controls. Our results showed that two SNPs had strong associations with schizophrenia (rs821616: Allele A > T, chi(2) = 7.8006, df = 1, P = 0.0052; Genotype, chi(2) = 7.7935, df = 2, P = 0.0203; rs821597: Allele A > G, chi(2) = 9.5404, df = 1, P = 0.0020; Genotype, chi(2) = 12.2780, df = 2, P = 0.0022). When haplotypes were constructed with two, three, and four markers, a number of haplotype combinations, especially those including rs821616 and rs821597, were significantly associated with schizophrenia. Furthermore, there was a strong evidence for association in a four-marker haplotype analysis (chi(2) = 7.686, df = 4, P = 0.005581, corrected P = 0.006199). Although the case-control and family-based association studies both suggest that DISC1 gene may play a role in genetic susceptibility to schizophrenia, the risk haplotypic combinations have subtle differences in the two studies. Our findings provide further evidence for DISC1 as a predisposing gene involved in schizophrenia in the Chinese Han Population. (c) 2007 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000245686600002
引用统计
被引频次:59[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66533
专题北京大学精神卫生研究所
作者单位Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
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GB/T 7714
Qu, Mei,Tang, Fulei,Yue, Weihua,et al. Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han Population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2007,144B(3):266-270.
APA Qu, Mei.,Tang, Fulei.,Yue, Weihua.,Ruan, Yan.,Lu, Tianlan.,...&Zhang, Dai.(2007).Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han Population.AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,144B(3),266-270.
MLA Qu, Mei,et al."Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han Population".AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 144B.3(2007):266-270.
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