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学科主题: 精神卫生
题名:
Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han Population
作者: Qu, Mei; Tang, Fulei; Yue, Weihua; Ruan, Yan; Lu, Tianlan; Liu, Zhonghua; Zhang, Handi; Han, Yonghua; Zhang, Darong; Wang, Fei; Zhang, Dai
关键词: case-control study ; SNP ; haplotype ; linkage disequilibrium.
刊名: AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
发表日期: 2007-04-05
DOI: 10.1002/ajmg.b.30322
卷: 144B, 期:3, 页:266-270
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Psychiatry
研究领域[WOS]: Genetics & Heredity ; Psychiatry
关键词[WOS]: BIPOLAR DISORDER ; SCOTTISH POPULATION ; NEURITE OUTGROWTH ; CHROMOSOME 1Q ; LINKAGE ; TRANSLOCATION ; NUDEL ; LOCI ; COMPLEX ; PROTEIN
英文摘要:

Disrupted-in-Schizophrenia-1 (DISC1) is located on 1q42.1, one of the most promising susceptibility loci in schizophrenia linkage studies. A non-synonymous genetic variation rs821616 (Ser704Cys) in DISC1, has recently been shown to be associated with schizophrenia in family-based study [Callicott et al. (2005); Proc Natl Acad Sci USA 102: 8627-8632]. In order to further confirm this issue, we examined four single nucleotide polymorphisms (SNPs) in a chromosomal region spanning 42 kb of this gene, namely rs821616, rs821597, rs4658971, and rs843979, in Chinese sample of 313 schizophrenia patients and 317 healthy controls. Our results showed that two SNPs had strong associations with schizophrenia (rs821616: Allele A > T, chi(2) = 7.8006, df = 1, P = 0.0052; Genotype, chi(2) = 7.7935, df = 2, P = 0.0203; rs821597: Allele A > G, chi(2) = 9.5404, df = 1, P = 0.0020; Genotype, chi(2) = 12.2780, df = 2, P = 0.0022). When haplotypes were constructed with two, three, and four markers, a number of haplotype combinations, especially those including rs821616 and rs821597, were significantly associated with schizophrenia. Furthermore, there was a strong evidence for association in a four-marker haplotype analysis (chi(2) = 7.686, df = 4, P = 0.005581, corrected P = 0.006199). Although the case-control and family-based association studies both suggest that DISC1 gene may play a role in genetic susceptibility to schizophrenia, the risk haplotypic combinations have subtle differences in the two studies. Our findings provide further evidence for DISC1 as a predisposing gene involved in schizophrenia in the Chinese Han Population. (c) 2007 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000245686600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66533
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Qu, Mei,Tang, Fulei,Yue, Weihua,et al. Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han Population[J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS,2007,144B(3):266-270.
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