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Role of salivary anti-SSA/B antibodies for diagnosing primary Sjogren′s syndrome
Wei, Pan1; Li, Chunlei1; Qiang, Lu1; He, Jing2; Li, Zhanguo2; Hua, Hong1
关键词Primary Sjogren&prime s syndrome salivary diagnostics anti-SSA autoantibodies anti-SSB autoantibodies
刊名MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
2015-03-01
DOI10.4317/medoral.20199
20期:2页:E156-E160
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]SYSTEMIC-LUPUS-ERYTHEMATOSUS ; REVISED CRITERIA ; CLASSIFICATION ; AUTOANTIBODIES ; ASSOCIATION
英文摘要

The diagnosis of primary Sjogren′s syndrome (pSS) is complex, and the saliva test is a potential method to improve the existing diagnostic criteria.

Objective: To estimate the diagnostic accuracy of salivary anti-SSA/B antibodies in primary Sjogren′s syndrome (pSS), and to analyze their correlations with clinical and laboratory profiles.

Study Design: This study enrolled 100 pSS patients and 140 non-pSS controls, including 40 rheumatoid arthritis (RA) patients, 40 systemic lupus erythematosus (SLE) patients, and 60 healthy controls. Unstimulated whole saliva and stimulated parotid saliva samples were collected from the subjects. Salivary anti-SSA/B antibodies were measured using an enzyme-linked immunosorbent assay (ELISA). Clinical and laboratory data were retrieved from the medical records.

Results: In the pSS group, the sensitivity of anti-SSA and anti-SSB antibodies in whole saliva was 49% and 29%, respectively, and the specificity was 87.5% and 95%. The sensitivity of anti-SSA and anti-SSB antibodies in parotid saliva was 32% and 8%, respectively, and the specificity was 95.52% and 97.86%, respectively. In the pSS group, the diagnostic accuracy of anti-SSA/B antibodies in whole saliva was significantly higher than in parotid saliva (p<0.05), but was significantly lower than in serum (p<0.05). The salivary flow rate in the pSS group positive for whole salivary anti-SSA was significantly lower than in the negative group (p<0.05). The prevalence of rheumatoid factor and antinuclear factor were significantly higher in salivary SSB-positive pSS patients than in SSB-negative patients (p<0.05).

Conclusions: Compared to parotid saliva, whole saliva is a more suitable diagnostic fluid. Using salivary anti-SSA/B antibodies as a single test item is insufficient given the relatively low sensitivity. Further studies should investigate the possibility of combining tests for different salivary autoantibodies as a method for diagnosing pSS.

语种英语
WOS记录号WOS:000351923500006
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66541
专题北京大学口腔医学院
北京大学第二临床医学院_风湿免疫科
北京大学口腔医学院_口腔黏膜科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral Med, Beijing 100081, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wei, Pan,Li, Chunlei,Qiang, Lu,et al. Role of salivary anti-SSA/B antibodies for diagnosing primary Sjogren&prime;s syndrome[J]. MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL,2015,20(2):E156-E160.
APA Wei, Pan,Li, Chunlei,Qiang, Lu,He, Jing,Li, Zhanguo,&Hua, Hong.(2015).Role of salivary anti-SSA/B antibodies for diagnosing primary Sjogren′s syndrome.MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL,20(2),E156-E160.
MLA Wei, Pan,et al."Role of salivary anti-SSA/B antibodies for diagnosing primary Sjogren′s syndrome".MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL 20.2(2015):E156-E160.
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