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学科主题临床医学
Effect of metallothionein on tolerance of nitroglycerin in rats
Shakya, U; Chen, YH; Wang, XH; Tang, CS
关键词metallothionein drug tolerance nitroglycerin zinc compounds thoracic aorta nitroprusside hypotension vasodilation
刊名ACTA PHARMACOLOGICA SINICA
2000
21期:1页:87-90
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]ORGANIC NITRATES ; VASCULAR TOLERANCE ; NITRIC-OXIDE ; SUPEROXIDE ; MECHANISM ; RADICALS ; ZINC
英文摘要

AIM: To assess whether metallothionein (Met) could improve the nitroglycerin tolerance in vivo; METHODS: Nitrate tolerance was induced by 2-d treatment of nitroglycerin (Nit) patch (0.05 mg.h(-1)). Endogenous Met production was induced by pretreatment of ZnCl2 and coadministration of intravenous Met (15 mg kg(-1).d(-1)) 2 d with Nit in tolerant rats. The induction of Met production was confirmed by the assay of liver and plasma Met levels. RESULTS: ZnCl2 induced large amount of endogenous Met production in liver and plasma in Nit + ZnCl2 group than that in control group, (89+/-4) mu g/g tissue vs (11.0+/-2.4) mu g/ g tissue in liver, P < 0.01, and in plasma (85 +/- 6) mu g .L-1 vs (71+/-6) mu g.L-1, P < 0.01. There was no significant difference in plasma Met levels in Nit and control groups [(75 +/- 6) mu g.L-1 vs (71 +/- 6) mu g. L-1, P > 0.05]. The endogenous Met production enhanced the hypotensive response in Nit + ZnCl2 group [(15.7+/-0.8) kPa vs (11.5 +/- 0.6) kPa, n = 6, P < 0.05]. The maximal vessel relaxation induced by sodium nitroprusside (SNP) was the same in 4 different groups but the highest EC50(concentration which produces 50 % of the maximal response to SNP) was found in tolerant group [(42 +/- 9) nmol.L-1, P < 0.01]. CONCLUSION: Exogenous Met or induction of endogenous Met production antagonize the development of Nit tolerance.

语种英语
WOS记录号WOS:000084710700014
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66544
专题北京大学第一临床医学院_心血管内科
作者单位1.Beijing Med Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
2.Beijing Med Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Shakya, U,Chen, YH,Wang, XH,et al. Effect of metallothionein on tolerance of nitroglycerin in rats[J]. ACTA PHARMACOLOGICA SINICA,2000,21(1):87-90.
APA Shakya, U,Chen, YH,Wang, XH,&Tang, CS.(2000).Effect of metallothionein on tolerance of nitroglycerin in rats.ACTA PHARMACOLOGICA SINICA,21(1),87-90.
MLA Shakya, U,et al."Effect of metallothionein on tolerance of nitroglycerin in rats".ACTA PHARMACOLOGICA SINICA 21.1(2000):87-90.
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