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学科主题: 临床医学
题名:
Improved GFR estimation by combined creatinine and cystatin C measurements
作者: Ma, Y-C; Zuo, L.; Chen, J-H; Luo, Q.; Yu, X-Q; Li, Y.; Xu, J-S; Huang, S-M; Wang, L-N; Huang, W.; Wang, M.; Xu, G-B; Wang, H-Y
关键词: chronic kidney disease ; glomerular filtration rate ; estimate equation ; creatinine ; cystatin C
刊名: KIDNEY INTERNATIONAL
发表日期: 2007-12-01
DOI: 10.1038/sj.ki.5002566
卷: 72, 期:12, 页:1535-1542
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; CHRONIC KIDNEY-DISEASE ; RENAL-TRANSPLANT PATIENTS ; SERUM CREATININE ; ESTIMATING EQUATIONS ; PREDICTION EQUATION ; DIABETIC-PATIENTS ; PLASMA-CLEARANCE ; CHINESE PATIENTS ; FOLLOW-UP
英文摘要:

Plasma creatinine may not reflect glomerular filtration rate (GFR) especially in the early stages of chronic kidney disease (CKD). Plasma cystatin C (cysC), however, has the potential to more accurately determine early GFR reduction. We sought to improve the creatinine-based GFR estimation by including cysC measurements. We derived a reference GFR from standard dual plasma sampling (99m)Tc-DTPA clearance in a training cohort of 376 randomly selected adult Chinese patients with CKD. We compared reference values to estimated GFR and applied multiple regression models to one equation based solely on cysC, and to another combining plasma creatinine (Pcr) and cysC measurements of the training cohort. The results were validated by testing an additional 191 patients. The difference, precision, and accuracy of the two estimates were compared with the modified Modification of Diet in Renal Disease (MDRD) equation for Chinese patients, and another estimate combining cysC and modified MDRD calculations. The estimated GFR combining Pcr and cysC measurements more accurately matched the reference GFR at all stages of CKD than the other equations, particularly in patients with near-normal kidney function.

语种: 英语
WOS记录号: WOS:000251266100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66545
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, First Hosp, Div Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, First Hosp, Inst Nephrol, Beijing 100034, Peoples R China
3.ZheJang Med Coll, First Hosp, Dept Nephrol, Hangzhou, ZheJiang, Peoples R China
4.Peking Univ, SheZhen Hosp, Dept Nephrol, ShenZhen, Peoples R China
5.Sun Yat Sen Univ, First Hosp, Dept Nephrol, Guangzhou, Peoples R China
6.HeBei Med Univ, Third Hosp, Dept Nephrol, ShiJiaZhuang, Peoples R China
7.HeBei Med Univ, Fourth Hosp, Dept Nephrol, ShiJiaZhuang, Peoples R China
8.Sichuan Univ, HuaXi Hos, Dept Nephrol, Chengdu 610064, Peoples R China
9.China Med Univ, First Hosp, Dept Nephrol, Shenyang, Peoples R China
10.Capital Med Univ, TongRen Hosp, Dept Nephrol, Beijing, Peoples R China
11.Peking Univ, First Hosp, Dept Clin Lab, Beijing 100034, Peoples R China

Recommended Citation:
Ma, Y-C,Zuo, L.,Chen, J-H,et al. Improved GFR estimation by combined creatinine and cystatin C measurements[J]. KIDNEY INTERNATIONAL,2007,72(12):1535-1542.
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