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学科主题临床医学
Improved GFR estimation by combined creatinine and cystatin C measurements
Ma, Y-C; Zuo, L.; Chen, J-H; Luo, Q.; Yu, X-Q; Li, Y.; Xu, J-S; Huang, S-M; Wang, L-N; Huang, W.; Wang, M.; Xu, G-B; Wang, H-Y
关键词chronic kidney disease glomerular filtration rate estimate equation creatinine cystatin C
刊名KIDNEY INTERNATIONAL
2007-12-01
DOI10.1038/sj.ki.5002566
72期:12页:1535-1542
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]GLOMERULAR-FILTRATION-RATE ; CHRONIC KIDNEY-DISEASE ; RENAL-TRANSPLANT PATIENTS ; SERUM CREATININE ; ESTIMATING EQUATIONS ; PREDICTION EQUATION ; DIABETIC-PATIENTS ; PLASMA-CLEARANCE ; CHINESE PATIENTS ; FOLLOW-UP
英文摘要

Plasma creatinine may not reflect glomerular filtration rate (GFR) especially in the early stages of chronic kidney disease (CKD). Plasma cystatin C (cysC), however, has the potential to more accurately determine early GFR reduction. We sought to improve the creatinine-based GFR estimation by including cysC measurements. We derived a reference GFR from standard dual plasma sampling (99m)Tc-DTPA clearance in a training cohort of 376 randomly selected adult Chinese patients with CKD. We compared reference values to estimated GFR and applied multiple regression models to one equation based solely on cysC, and to another combining plasma creatinine (Pcr) and cysC measurements of the training cohort. The results were validated by testing an additional 191 patients. The difference, precision, and accuracy of the two estimates were compared with the modified Modification of Diet in Renal Disease (MDRD) equation for Chinese patients, and another estimate combining cysC and modified MDRD calculations. The estimated GFR combining Pcr and cysC measurements more accurately matched the reference GFR at all stages of CKD than the other equations, particularly in patients with near-normal kidney function.

语种英语
WOS记录号WOS:000251266100015
引用统计
被引频次:75[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66545
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, First Hosp, Div Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, First Hosp, Inst Nephrol, Beijing 100034, Peoples R China
3.ZheJang Med Coll, First Hosp, Dept Nephrol, Hangzhou, ZheJiang, Peoples R China
4.Peking Univ, SheZhen Hosp, Dept Nephrol, ShenZhen, Peoples R China
5.Sun Yat Sen Univ, First Hosp, Dept Nephrol, Guangzhou, Peoples R China
6.HeBei Med Univ, Third Hosp, Dept Nephrol, ShiJiaZhuang, Peoples R China
7.HeBei Med Univ, Fourth Hosp, Dept Nephrol, ShiJiaZhuang, Peoples R China
8.Sichuan Univ, HuaXi Hos, Dept Nephrol, Chengdu 610064, Peoples R China
9.China Med Univ, First Hosp, Dept Nephrol, Shenyang, Peoples R China
10.Capital Med Univ, TongRen Hosp, Dept Nephrol, Beijing, Peoples R China
11.Peking Univ, First Hosp, Dept Clin Lab, Beijing 100034, Peoples R China
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GB/T 7714
Ma, Y-C,Zuo, L.,Chen, J-H,et al. Improved GFR estimation by combined creatinine and cystatin C measurements[J]. KIDNEY INTERNATIONAL,2007,72(12):1535-1542.
APA Ma, Y-C.,Zuo, L..,Chen, J-H.,Luo, Q..,Yu, X-Q.,...&Wang, H-Y.(2007).Improved GFR estimation by combined creatinine and cystatin C measurements.KIDNEY INTERNATIONAL,72(12),1535-1542.
MLA Ma, Y-C,et al."Improved GFR estimation by combined creatinine and cystatin C measurements".KIDNEY INTERNATIONAL 72.12(2007):1535-1542.
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