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学科主题口腔医学
Magnetic bead-based salivary peptidome profiling for periodontal-orthodontic treatment
Zhang, Jieni1,2; Zhou, Shaonan1,2; Li, Ruoxuan3; Cao, Tian1,2; Zheng, Hui1,2; Wang, Xuedong1,2; Zhou, Yanheng1,2; Du, Ning1; Chen, Feng1; Lin, Jiuxiang1,2
关键词Periodontal-orthodontic treatment Peptidome Saliva MALDI-TOF MS
刊名PROTEOME SCIENCE
2012-11-06
DOI10.1186/1477-5956-10-63
10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]BREAST-CANCER PATIENTS ; BIOMARKER DISCOVERY ; THROMBOMODULIN ; INFLAMMATION ; PROTEOMICS ; OBESITY ; CELLS ; STAGE
英文摘要

Background: Patients with periodontitis seek periodontal-orthodontic treatment to address certain functional and aesthetic problems. However, little is known of the effect of periodontitis on orthodontic treatment. Thus, we compared the differences in peptide mass fingerprints of orthodontic patients with and without periodontitis by MALDI-TOF MS using a magnetic bead-based peptidome analysis of saliva samples. In this way, we aimed to identify and explore a panel of differentially-expressed specific peptides.

Results: Saliva samples from 24 patients (eight orthodontic patients without periodontitis, eight with periodontitis and another eight with periodontitis but no orthodontic treatment) were analyzed, and peptide mass fingerprints were created by scanning MS signals using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with magnetic beads. Nine mass peaks showed significant differences. Orthodontic patients in the group without periodontal disease showed higher mass peaks for seven peptides of the nine, whereas the mass peaks for the other two peptides were higher in the periodontal-orthodontic patients. Besides, these differentially-expressed peptides were sequenced.

Conclusions: The elucidated candidate biomarkers indicated interactions between periodontal condition and orthodontic treatment and their contributions to the changes of saliva protein profiles. Our results provide novel insight into the altered salivary protein profile during periodontal-orthodontic treatment, and may lead to the development of a therapeutic monitoring strategy for periodontics and orthodontics.

语种英语
WOS记录号WOS:000311968100001
项目编号PKUSS20110301
资助机构Peking University School of Stomatology
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66546
专题北京大学口腔医学院
北京大学口腔医学院_口腔正畸科
作者单位1.Peking Univ, Sch Stomatol, Dept Cent Lab, Beijing 100081, Peoples R China
2.Peking Univ, Sch Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
3.Capital Univ Med Sci, Dept Stomatol, Beijing An Zhen Hosp, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jieni,Zhou, Shaonan,Li, Ruoxuan,et al. Magnetic bead-based salivary peptidome profiling for periodontal-orthodontic treatment[J]. PROTEOME SCIENCE,2012,10.
APA Zhang, Jieni.,Zhou, Shaonan.,Li, Ruoxuan.,Cao, Tian.,Zheng, Hui.,...&Lin, Jiuxiang.(2012).Magnetic bead-based salivary peptidome profiling for periodontal-orthodontic treatment.PROTEOME SCIENCE,10.
MLA Zhang, Jieni,et al."Magnetic bead-based salivary peptidome profiling for periodontal-orthodontic treatment".PROTEOME SCIENCE 10(2012).
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