北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Baicalein Prevents 6-Hydroxydopamine-Induced Mitochondrial Dysfunction in SH-SY5Y Cells via Inhibition of Mitochondrial Oxidation and Up-Regulation of DJ-1 Protein Expression
作者: Wang, Yue-Hua1,2,3,4; Yu, Hai-Tao5; Pu, Xiao-Ping1; Du, Guan-Hua2,3,4
关键词: baicalein ; Parkinson&prime ; s disease ; 6-hydroxydopamine ; SH-SY5Y cells ; brain mitochondria
刊名: MOLECULES
发表日期: 2013-12-01
DOI: 10.3390/molecules181214726
卷: 18, 期:12, 页:14726-14738
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: EARLY-ONSET PARKINSONISM ; PC12 CELLS ; COMPLEX-I ; DISEASE ; STRESS ; DEATH ; NEUROTOXICITY ; APOPTOSIS ; PARK7 ; NEURODEGENERATION
英文摘要:

Parkinson′s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons at the substantia nigra. Mitochondrial dysfunction is involved in the mechanism of cell damage in Parkinson′s disease (PD). 6-Hydroxydopamine (6-OHDA) is a dopamine analog which specifically damages dopaminergic neurons. Baicalein has been previously reported to have potential in the treatment of PD. The purpose of the present study was to investigate the mechanism of action of baicalein against 6-OHDA injury in SH-SY5Y cells. The results showed that baicalein significantly alleviated alterations of mitochondrial redox activity and mitochondrial membrane potential induced by 6-OHDA in a dose-dependent manner in SH-SY5Y cells compared with vehicle group. Futhermore, baicalein decreased the production of ROS and upregulated the DJ-1 protein expression in SH-SY5Y cells. In addition, baicalein also inhibited ROS production and lipid peroxidation (IC50 = 6.32 +/- 0.03 mu M) in rat brain mitochondia. In summary, the underlying mechanisms of baicalein against 6-OHDA-induced mitochondrial dysfunction may involve inhibition of mitochondrial oxidation and upregulation of DJ-1 protein expression.

语种: 英语
所属项目编号: 30973889 ; 2012ZX09103101-078 ; 2012ZX09103201-042 ; 2011ZX09401-014 ; 200902008
项目资助者: National Natural Science Foundation of China ; Science and Technology Major Projects: Significant New-Drugs Creation ; Research Special Fund for Public Welfare Industry of Health
WOS记录号: WOS:000330315700017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66548
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target Identificat, Beijing 100050, Peoples R China
3.Jiangsu Kanon Pharmaceut Co Ltd, Lianyungang 222047, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China
5.Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

Recommended Citation:
Wang, Yue-Hua,Yu, Hai-Tao,Pu, Xiao-Ping,et al. Baicalein Prevents 6-Hydroxydopamine-Induced Mitochondrial Dysfunction in SH-SY5Y Cells via Inhibition of Mitochondrial Oxidation and Up-Regulation of DJ-1 Protein Expression[J]. MOLECULES,2013,18(12):14726-14738.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Yue-Hua]'s Articles
[Yu, Hai-Tao]'s Articles
[Pu, Xiao-Ping]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Yue-Hua]‘s Articles
[Yu, Hai-Tao]‘s Articles
[Pu, Xiao-Ping]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace