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Baicalein Prevents 6-Hydroxydopamine-Induced Mitochondrial Dysfunction in SH-SY5Y Cells via Inhibition of Mitochondrial Oxidation and Up-Regulation of DJ-1 Protein Expression
Wang, Yue-Hua1,2,3,4; Yu, Hai-Tao5; Pu, Xiao-Ping1; Du, Guan-Hua2,3,4
关键词baicalein Parkinson&prime s disease 6-hydroxydopamine SH-SY5Y cells brain mitochondria
刊名MOLECULES
2013-12-01
DOI10.3390/molecules181214726
18期:12页:14726-14738
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]EARLY-ONSET PARKINSONISM ; PC12 CELLS ; COMPLEX-I ; DISEASE ; STRESS ; DEATH ; NEUROTOXICITY ; APOPTOSIS ; PARK7 ; NEURODEGENERATION
英文摘要

Parkinson′s disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons at the substantia nigra. Mitochondrial dysfunction is involved in the mechanism of cell damage in Parkinson′s disease (PD). 6-Hydroxydopamine (6-OHDA) is a dopamine analog which specifically damages dopaminergic neurons. Baicalein has been previously reported to have potential in the treatment of PD. The purpose of the present study was to investigate the mechanism of action of baicalein against 6-OHDA injury in SH-SY5Y cells. The results showed that baicalein significantly alleviated alterations of mitochondrial redox activity and mitochondrial membrane potential induced by 6-OHDA in a dose-dependent manner in SH-SY5Y cells compared with vehicle group. Futhermore, baicalein decreased the production of ROS and upregulated the DJ-1 protein expression in SH-SY5Y cells. In addition, baicalein also inhibited ROS production and lipid peroxidation (IC50 = 6.32 +/- 0.03 mu M) in rat brain mitochondia. In summary, the underlying mechanisms of baicalein against 6-OHDA-induced mitochondrial dysfunction may involve inhibition of mitochondrial oxidation and upregulation of DJ-1 protein expression.

语种英语
WOS记录号WOS:000330315700017
项目编号30973889 ; 2012ZX09103101-078 ; 2012ZX09103201-042 ; 2011ZX09401-014 ; 200902008
资助机构National Natural Science Foundation of China ; Science and Technology Major Projects: Significant New-Drugs Creation ; Research Special Fund for Public Welfare Industry of Health
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66548
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
2.Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target Identificat, Beijing 100050, Peoples R China
3.Jiangsu Kanon Pharmaceut Co Ltd, Lianyungang 222047, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China
5.Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
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GB/T 7714
Wang, Yue-Hua,Yu, Hai-Tao,Pu, Xiao-Ping,et al. Baicalein Prevents 6-Hydroxydopamine-Induced Mitochondrial Dysfunction in SH-SY5Y Cells via Inhibition of Mitochondrial Oxidation and Up-Regulation of DJ-1 Protein Expression[J]. MOLECULES,2013,18(12):14726-14738.
APA Wang, Yue-Hua,Yu, Hai-Tao,Pu, Xiao-Ping,&Du, Guan-Hua.(2013).Baicalein Prevents 6-Hydroxydopamine-Induced Mitochondrial Dysfunction in SH-SY5Y Cells via Inhibition of Mitochondrial Oxidation and Up-Regulation of DJ-1 Protein Expression.MOLECULES,18(12),14726-14738.
MLA Wang, Yue-Hua,et al."Baicalein Prevents 6-Hydroxydopamine-Induced Mitochondrial Dysfunction in SH-SY5Y Cells via Inhibition of Mitochondrial Oxidation and Up-Regulation of DJ-1 Protein Expression".MOLECULES 18.12(2013):14726-14738.
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