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The effect of methadone maintenance on illicit opioid use, human immunodeficiency virus and hepatitis C virus infection, health status, employment, and criminal activity among heroin abusers during 6 months of treatment in China
Shi, Jie2; Zhao, Li-Yan1; Epstein, David H.3; Zhao, Chengzheng2; Shuai, Yinliang4; Yan, Bin4; Jin, Jun4; Lu, Lin1
关键词methadone maintenance therapy HIV infection HCV infection health status severity of dependence depression employment activity criminal activity heroin abuse China
刊名JOURNAL OF ADDICTION MEDICINE
2007-12-01
1期:4页:186-190
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Substance Abuse
研究领域[WOS]Substance Abuse
关键词[WOS]ADDICTION SEVERITY INDEX ; LONG-TERM ; MEDICAL-TREATMENT ; OPIATE ADDICTION ; DEPENDENCE ; TRIAL ; DETOXIFICATION ; INSTRUMENT ; SCALE
英文摘要

Purpose:This study was designed to evaluate the effects of methadone maintenance treatment (MMT) on severity of dependence, depression, human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection, health status, employment, and criminal activity among heroin abusers after 3 and 6 months of treatment, compared with baseline, in China.

Methods: A total of 102 methadone maintenance treatment (MMT) patients (87 men and 15 women; mean age, 36.1 years; standard deviation = 6.9) without major medical or psychiatric comorbidity participated in the experimental procedure. They were given oral methadone (maximum daily dose 80 mg, minimum daily dose 30 mg). Opioid use was assessed by twice-weekly urinalysis; HIV and HCV statu′s were assessed by standard blood tests. Questionnaires were administered to assess blood-borne-virus risk behavior, severity of dependence, depression, health status, employment, and criminal activity. Changes over time were evaluated by 1-way analysis of variance (ANOVA) followed by post hoc t tests.

Results: Opioid use was reduced from 26.7 days per month at baseline to 0.7 and 0.0 days at 3 and 6 months, respectively. No participant seroconverted to HIV and HCV positivity during the 6 months of MMT. Health status significantly improved, as did severity of dependence, depression, and criminal activity, after 3 and 6 months MMT.

Conclusions: The results support the broad beneficial effects of MMT in China.

语种英语
WOS记录号WOS:000256166000003
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66551
专题中国药物依赖性研究所
作者单位1.Beijing Ankang Hosp, Beijing, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Dept Clin Pharmacol, Beijing, Peoples R China
4.Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD USA
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GB/T 7714
Shi, Jie,Zhao, Li-Yan,Epstein, David H.,et al. The effect of methadone maintenance on illicit opioid use, human immunodeficiency virus and hepatitis C virus infection, health status, employment, and criminal activity among heroin abusers during 6 months of treatment in China[J]. JOURNAL OF ADDICTION MEDICINE,2007,1(4):186-190.
APA Shi, Jie.,Zhao, Li-Yan.,Epstein, David H..,Zhao, Chengzheng.,Shuai, Yinliang.,...&Lu, Lin.(2007).The effect of methadone maintenance on illicit opioid use, human immunodeficiency virus and hepatitis C virus infection, health status, employment, and criminal activity among heroin abusers during 6 months of treatment in China.JOURNAL OF ADDICTION MEDICINE,1(4),186-190.
MLA Shi, Jie,et al."The effect of methadone maintenance on illicit opioid use, human immunodeficiency virus and hepatitis C virus infection, health status, employment, and criminal activity among heroin abusers during 6 months of treatment in China".JOURNAL OF ADDICTION MEDICINE 1.4(2007):186-190.
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