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学科主题: 药物依赖
题名:
The effect of methadone maintenance on illicit opioid use, human immunodeficiency virus and hepatitis C virus infection, health status, employment, and criminal activity among heroin abusers during 6 months of treatment in China
作者: Shi, Jie2; Zhao, Li-Yan1; Epstein, David H.3; Zhao, Chengzheng2; Shuai, Yinliang4; Yan, Bin4; Jin, Jun4; Lu, Lin1
关键词: methadone maintenance therapy ; HIV infection ; HCV infection ; health status ; severity of dependence ; depression ; employment activity ; criminal activity ; heroin abuse ; China
刊名: JOURNAL OF ADDICTION MEDICINE
发表日期: 2007-12-01
卷: 1, 期:4, 页:186-190
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Substance Abuse
研究领域[WOS]: Substance Abuse
关键词[WOS]: ADDICTION SEVERITY INDEX ; LONG-TERM ; MEDICAL-TREATMENT ; OPIATE ADDICTION ; DEPENDENCE ; TRIAL ; DETOXIFICATION ; INSTRUMENT ; SCALE
英文摘要:

Purpose:This study was designed to evaluate the effects of methadone maintenance treatment (MMT) on severity of dependence, depression, human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection, health status, employment, and criminal activity among heroin abusers after 3 and 6 months of treatment, compared with baseline, in China.

Methods: A total of 102 methadone maintenance treatment (MMT) patients (87 men and 15 women; mean age, 36.1 years; standard deviation = 6.9) without major medical or psychiatric comorbidity participated in the experimental procedure. They were given oral methadone (maximum daily dose 80 mg, minimum daily dose 30 mg). Opioid use was assessed by twice-weekly urinalysis; HIV and HCV statu′s were assessed by standard blood tests. Questionnaires were administered to assess blood-borne-virus risk behavior, severity of dependence, depression, health status, employment, and criminal activity. Changes over time were evaluated by 1-way analysis of variance (ANOVA) followed by post hoc t tests.

Results: Opioid use was reduced from 26.7 days per month at baseline to 0.7 and 0.0 days at 3 and 6 months, respectively. No participant seroconverted to HIV and HCV positivity during the 6 months of MMT. Health status significantly improved, as did severity of dependence, depression, and criminal activity, after 3 and 6 months MMT.

Conclusions: The results support the broad beneficial effects of MMT in China.

语种: 英语
WOS记录号: WOS:000256166000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66551
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Beijing Ankang Hosp, Beijing, Peoples R China
2.Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Dept Clin Pharmacol, Beijing, Peoples R China
4.Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD USA

Recommended Citation:
Shi, Jie,Zhao, Li-Yan,Epstein, David H.,et al. The effect of methadone maintenance on illicit opioid use, human immunodeficiency virus and hepatitis C virus infection, health status, employment, and criminal activity among heroin abusers during 6 months of treatment in China[J]. JOURNAL OF ADDICTION MEDICINE,2007,1(4):186-190.
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