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学科主题临床医学
Association of CD28 gene polymorphism with cervical cancer risk in a Chinese population
Chen, X.1,2; Li, H.3; Qiao, Y.1,2; Yu, D.1,2; Guo, H.3; Tan, W.1,2; Lin, D.1,2
刊名INTERNATIONAL JOURNAL OF IMMUNOGENETICS
2011-02-01
DOI10.1111/j.1744-313X.2010.00969.x
38期:1页:51-54
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Immunology
研究领域[WOS]Genetics & Heredity ; Immunology
关键词[WOS]CTLA-4
英文摘要

P>Human papilloma virus plays a causal role in cervical carcinogenesis. However, only a small portion of infected individuals develop cervical cancer. Host genetic factors may confer susceptibility to this disease. CD28 participates in the maintenance of immune homeostasis as an important positive co-stimulatory molecule. Allelic variation of immuno-modulatory genes may be associated with alteration in immune function. This study investigated the associations between CD28 IVS3 +17T > C polymorphism and risk of cervical cancer in the Chinese population. Genotypes of CD28 polymorphism were detected in 619 cases with primary cervical cancer and in 985 normal controls. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression. A higher frequency of CD28 +17TC heterozygote was determined in patients in comparison with controls (19.4% versus 12.5%). Subjects carrying at least one CD28 IVS3 +17 C allele (TC or CC genotype) had increased risk of cervical cancer (OR = 1.66, 95% CI = 1.27-2.17). This study suggests that the CD28 IVS3 +17T > C polymorphism might be genetic susceptibility factor for cervical cancer in Chinese population.

语种英语
WOS记录号WOS:000285880900009
项目编号30530710 ; NCET-05-0171 ; 20070001785
资助机构National Natural Science Foundation ; Program for New Century Excellent Talents in University ; h.D. Programs Foundation of Ministry of Education of China for New Teacher
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66553
专题北京大学第三临床医学院
北京大学第二临床医学院_麻醉科
作者单位1.Chinese Acad Med Sci, Beijing Key Lab Carcinogenesis & Canc Prevent, Dept Etiol & Carcinogenesis, Canc Inst & Hosp,State Key Lab Mol Oncol, Beijing 100021, Peoples R China
2.Peking Union Med Coll, Beijing 100021, Peoples R China
3.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, X.,Li, H.,Qiao, Y.,et al. Association of CD28 gene polymorphism with cervical cancer risk in a Chinese population[J]. INTERNATIONAL JOURNAL OF IMMUNOGENETICS,2011,38(1):51-54.
APA Chen, X..,Li, H..,Qiao, Y..,Yu, D..,Guo, H..,...&Lin, D..(2011).Association of CD28 gene polymorphism with cervical cancer risk in a Chinese population.INTERNATIONAL JOURNAL OF IMMUNOGENETICS,38(1),51-54.
MLA Chen, X.,et al."Association of CD28 gene polymorphism with cervical cancer risk in a Chinese population".INTERNATIONAL JOURNAL OF IMMUNOGENETICS 38.1(2011):51-54.
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