|Differential diagnosis of solitary pulmonary nodules using Tc-99m-3P(4)-RGD(2) scintigraphy|
|Ma, Qingjie1; Ji, Bin1; Jia, Bing2; Gao, Shi1; Ji, Tiefeng; Wang, Xueju3; Han, Zhenguo4; Zhao, Guoqing1|
|关键词||Integrin alpha(nu)beta(3) Tc-99m-3P(4)-RGD(2) Solitary pulmonary nodule Scintigraphy|
|刊名||EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING|
|WOS标题词||Science & Technology|
|类目[WOS]||Radiology, Nuclear Medicine & Medical Imaging|
|研究领域[WOS]||Radiology, Nuclear Medicine & Medical Imaging|
|关键词[WOS]||INTEGRIN ALPHA(V)BETA(3) EXPRESSION ; POSITRON-EMISSION-TOMOGRAPHY ; CELL LUNG-CANCER ; BREAST-CANCER ; MANAGEMENT ; PET/CT ; ANGIOGENESIS ; ACCURACY ; LESIONS|
Purpose Targeting of integrin alpha(nu)beta(3) with molecular imaging agents offers great potential in early detection and monitoring of tumour angiogenesis. Recently, an RGD (Arg-Gly-Asp) tracer, Tc-99m-3P(4)-RGD(2), with high affinity to integrin alpha(nu)beta(3) and in vivo tumour uptake was developed. In this study, we evaluate the feasibility of this novel radiotracer in the noninvasive differentiation of solitary pulmonary nodules (SPNs).
Methods Twenty-one patients with SPNs on CT were studied scintigraphically after administration of Tc-99m-3P(4)-RGD(2) with a dose of 939 +/- 118 MBq. Image interpretation using a 5-point scale was performed by one thoracic radiologist for CT and three nuclear medicine radiologists for single photon emission computed tomography (SPECT). Scintigraphic images were also analysed semi-quantitatively by calculating tumour to normal tissue ratio (T/N). The "gold standard" was based on the histopathological diagnosis of the surgical samples from all recruited patients. A fraction of the samples were analysed immunohistochemically for integrin alpha(nu)beta(3) expression.
Results Among the 21 SPNs, 15 (71%) were diagnosed as malignant and 6 (29%) were benign. The mean size for SPNs was 2.2 +/- 0.6 cm. The sensitivity and specificity for CT interpretation, SPECT visual and semiquantitative analysis were 80/67%, 100/67% and 100/67%, respectively. All SPNs classified as indeterminate by CT were correctly diagnosed by Tc-99m-3P(4)-RGD(2) scintigraphy. The empirical receiver-operating characteristic (ROC) areas were 0.811 [95% confidence interval (CI) 58-95%] for CT, 0.833 (95% CI 61-96%) for SPECT and 0.844 (95% CI 62-96%) for T/N ratios, respectively. Immunohistochemistry confirmed alpha(nu)beta(3) expression in malignant and benign nodules with uptake in Tc-99m-3P(4)-RGD(2) scintigraphy.
Conclusion In this first-in-human study, we demonstrated the feasibility of using Tc-99m-3P(4)-RGD(2) scintigraphy in differentiating SPNs. This procedure appears to be highly sensitive in detection of malignant SPNs. SPECT visual analysis seems to be sufficient for characterization of SPNs.
|资助机构||Science and Technology Department of Jilin Province|
|作者单位||1.Jilin Univ, Dept Nucl Med, China Japan Union Hosp, Changchun 130033, Peoples R China|
2.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
3.Jilin Univ, Dept Pathol, China Japan Union Hosp, Changchun 130033, Peoples R China
4.Jilin Univ, Dept Thorac Surg, China Japan Union Hosp, Changchun 130033, Peoples R China
|Ma, Qingjie,Ji, Bin,Jia, Bing,et al. Differential diagnosis of solitary pulmonary nodules using Tc-99m-3P(4)-RGD(2) scintigraphy[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2011,38(12):2145-2152.|
|APA||Ma, Qingjie.,Ji, Bin.,Jia, Bing.,Gao, Shi.,Ji, Tiefeng.,...&Zhao, Guoqing.(2011).Differential diagnosis of solitary pulmonary nodules using Tc-99m-3P(4)-RGD(2) scintigraphy.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,38(12),2145-2152.|
|MLA||Ma, Qingjie,et al."Differential diagnosis of solitary pulmonary nodules using Tc-99m-3P(4)-RGD(2) scintigraphy".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 38.12(2011):2145-2152.|