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Differential diagnosis of solitary pulmonary nodules using Tc-99m-3P(4)-RGD(2) scintigraphy
Ma, Qingjie1; Ji, Bin1; Jia, Bing2; Gao, Shi1; Ji, Tiefeng; Wang, Xueju3; Han, Zhenguo4; Zhao, Guoqing1
关键词Integrin alpha(nu)beta(3) Tc-99m-3P(4)-RGD(2) Solitary pulmonary nodule Scintigraphy
刊名EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
2011-12-01
DOI10.1007/s00259-011-1901-2
38期:12页:2145-2152
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
资助者Science and Technology Department of Jilin Province ; Science and Technology Department of Jilin Province
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]INTEGRIN ALPHA(V)BETA(3) EXPRESSION ; POSITRON-EMISSION-TOMOGRAPHY ; CELL LUNG-CANCER ; BREAST-CANCER ; MANAGEMENT ; PET/CT ; ANGIOGENESIS ; ACCURACY ; LESIONS
英文摘要

Purpose Targeting of integrin alpha(nu)beta(3) with molecular imaging agents offers great potential in early detection and monitoring of tumour angiogenesis. Recently, an RGD (Arg-Gly-Asp) tracer, Tc-99m-3P(4)-RGD(2), with high affinity to integrin alpha(nu)beta(3) and in vivo tumour uptake was developed. In this study, we evaluate the feasibility of this novel radiotracer in the noninvasive differentiation of solitary pulmonary nodules (SPNs).

Methods Twenty-one patients with SPNs on CT were studied scintigraphically after administration of Tc-99m-3P(4)-RGD(2) with a dose of 939 +/- 118 MBq. Image interpretation using a 5-point scale was performed by one thoracic radiologist for CT and three nuclear medicine radiologists for single photon emission computed tomography (SPECT). Scintigraphic images were also analysed semi-quantitatively by calculating tumour to normal tissue ratio (T/N). The "gold standard" was based on the histopathological diagnosis of the surgical samples from all recruited patients. A fraction of the samples were analysed immunohistochemically for integrin alpha(nu)beta(3) expression.

Results Among the 21 SPNs, 15 (71%) were diagnosed as malignant and 6 (29%) were benign. The mean size for SPNs was 2.2 +/- 0.6 cm. The sensitivity and specificity for CT interpretation, SPECT visual and semiquantitative analysis were 80/67%, 100/67% and 100/67%, respectively. All SPNs classified as indeterminate by CT were correctly diagnosed by Tc-99m-3P(4)-RGD(2) scintigraphy. The empirical receiver-operating characteristic (ROC) areas were 0.811 [95% confidence interval (CI) 58-95%] for CT, 0.833 (95% CI 61-96%) for SPECT and 0.844 (95% CI 62-96%) for T/N ratios, respectively. Immunohistochemistry confirmed alpha(nu)beta(3) expression in malignant and benign nodules with uptake in Tc-99m-3P(4)-RGD(2) scintigraphy.

Conclusion In this first-in-human study, we demonstrated the feasibility of using Tc-99m-3P(4)-RGD(2) scintigraphy in differentiating SPNs. This procedure appears to be highly sensitive in detection of malignant SPNs. SPECT visual analysis seems to be sufficient for characterization of SPNs.

语种英语
所属项目编号201015185
资助者Science and Technology Department of Jilin Province ; Science and Technology Department of Jilin Province
WOS记录号WOS:000297732700006
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66555
专题北京大学医药卫生分析中心
作者单位1.Jilin Univ, Dept Nucl Med, China Japan Union Hosp, Changchun 130033, Peoples R China
2.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
3.Jilin Univ, Dept Pathol, China Japan Union Hosp, Changchun 130033, Peoples R China
4.Jilin Univ, Dept Thorac Surg, China Japan Union Hosp, Changchun 130033, Peoples R China
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GB/T 7714
Ma, Qingjie,Ji, Bin,Jia, Bing,et al. Differential diagnosis of solitary pulmonary nodules using Tc-99m-3P(4)-RGD(2) scintigraphy[J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,2011,38(12):2145-2152.
APA Ma, Qingjie.,Ji, Bin.,Jia, Bing.,Gao, Shi.,Ji, Tiefeng.,...&Zhao, Guoqing.(2011).Differential diagnosis of solitary pulmonary nodules using Tc-99m-3P(4)-RGD(2) scintigraphy.EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING,38(12),2145-2152.
MLA Ma, Qingjie,et al."Differential diagnosis of solitary pulmonary nodules using Tc-99m-3P(4)-RGD(2) scintigraphy".EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 38.12(2011):2145-2152.
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