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学科主题: 临床医学
题名:
Study of the Diagnostic Efficacy of Real-Time Optical Coherence Tomography as an Adjunct to Unaided Visual Inspection With Acetic Acid for the Diagnosis of Preinvasive and Invasive Neoplasia of the Uterine Cervix
作者: Wulan, Na1; Rasool, Nabila2; Belinson, Suzanne E.3; Wang, Chun1; Rong, Xuan1; Zhang, Wei1; Zhu, YaSha1; Yang, Bin4; Tresser, Nancy J.5; Mohr, Mary2; Wu, RuiFang1; Belinson, Jerome L.2
关键词: Cervical intraepithelial neoplasia ; Optical coherence tomography (OCT) ; Visual inspection with acetic acid (VIA)
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
发表日期: 2010-04-01
DOI: 10.1111/IGC.0b013e3181d09fbb
卷: 20, 期:3, 页:422-427
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Obstetrics & Gynecology
研究领域[WOS]: Oncology ; Obstetrics & Gynecology
关键词[WOS]: CANCER ; COLPOSCOPY ; PRECURSORS ; CARCINOMA ; LESIONS ; TREAT ; TRIAL ; INDIA
英文摘要:

Objectives: To determine the sensitivity and specificity of optical coherence tomography (OCT) as an adjunct to unaided visual inspection using acetic acid (VIA) in the detection of cervical intraepithelial neoplasia 2 (CIN 2) in a real-time clinical evaluation.

Background: This clinical study was a prospective cross-sectional comparative trial that screened 1000 patients (aged 30-50 years) in a low-resource setting. Women with abnormal cervical cytology or positive human papillomavirus (HPV) tests were referred for further evaluation including VIA, OCT imaging, colposcopy, and cervical biopsies.

Methods: The VIA diagnoses were coded by quadrant. The OCT was then performed in all VIA-positive areas and at the squamocolumnar junction in all 4 quadrants. All patients were colposcoped; assessed by quadrant with biopsies at 2, 4, 8, and 10 o′clock; all abnormal areas were biopsied; and endocervical curettage was performed. Data were analyzed using generalized estimating equations and logistic regression.

Results: Of the 1000 patients, 175 (17.5%) were HPV positive, 93 (9.3%) had abnormal cervical cytology greater than or equal to atypical squamous cells of undetermined significance, and 211 (21.1%) were either HPV positive or had abnormal cytology. The VIA, OCT, colposcopy, and biopsies were completed on 183 (86.7%) of 211 women. For VIA alone, the sensitivity and specificity in detecting lesions greater than or equal to CIN 2 was 43% and 96%. With the addition of OCT, the sensitivity increases to 62% with a specificity of 80%.

Conclusions: With the addition of OCT, the sensitivity of VIA increased in all analyses for the detection of greater than or equal to CIN II, with a loss in specificity. We hope that the potential of this technology will be realized when a computer algorithm is generated to aid in image interpretation.

语种: 英语
WOS记录号: WOS:000276899900019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66556
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Imalux Corp, Cleveland, OH USA
2.Northwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA
3.Cleveland Clin, Dept Anat Pathol, Cleveland, OH 44106 USA
4.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen, Peoples R China
5.Cleveland Clin, Dept Obstet & Gynecol, Cleveland, OH 44106 USA

Recommended Citation:
Wulan, Na,Rasool, Nabila,Belinson, Suzanne E.,et al. Study of the Diagnostic Efficacy of Real-Time Optical Coherence Tomography as an Adjunct to Unaided Visual Inspection With Acetic Acid for the Diagnosis of Preinvasive and Invasive Neoplasia of the Uterine Cervix[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2010,20(3):422-427.
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