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学科主题临床医学
Study of the Diagnostic Efficacy of Real-Time Optical Coherence Tomography as an Adjunct to Unaided Visual Inspection With Acetic Acid for the Diagnosis of Preinvasive and Invasive Neoplasia of the Uterine Cervix
Wulan, Na1; Rasool, Nabila2; Belinson, Suzanne E.3; Wang, Chun1; Rong, Xuan1; Zhang, Wei1; Zhu, YaSha1; Yang, Bin4; Tresser, Nancy J.5; Mohr, Mary2; Wu, RuiFang1; Belinson, Jerome L.2
关键词Cervical intraepithelial neoplasia Optical coherence tomography (OCT) Visual inspection with acetic acid (VIA)
刊名INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
2010-04-01
DOI10.1111/IGC.0b013e3181d09fbb
20期:3页:422-427
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Obstetrics & Gynecology
研究领域[WOS]Oncology ; Obstetrics & Gynecology
关键词[WOS]CANCER ; COLPOSCOPY ; PRECURSORS ; CARCINOMA ; LESIONS ; TREAT ; TRIAL ; INDIA
英文摘要

Objectives: To determine the sensitivity and specificity of optical coherence tomography (OCT) as an adjunct to unaided visual inspection using acetic acid (VIA) in the detection of cervical intraepithelial neoplasia 2 (CIN 2) in a real-time clinical evaluation.

Background: This clinical study was a prospective cross-sectional comparative trial that screened 1000 patients (aged 30-50 years) in a low-resource setting. Women with abnormal cervical cytology or positive human papillomavirus (HPV) tests were referred for further evaluation including VIA, OCT imaging, colposcopy, and cervical biopsies.

Methods: The VIA diagnoses were coded by quadrant. The OCT was then performed in all VIA-positive areas and at the squamocolumnar junction in all 4 quadrants. All patients were colposcoped; assessed by quadrant with biopsies at 2, 4, 8, and 10 o′clock; all abnormal areas were biopsied; and endocervical curettage was performed. Data were analyzed using generalized estimating equations and logistic regression.

Results: Of the 1000 patients, 175 (17.5%) were HPV positive, 93 (9.3%) had abnormal cervical cytology greater than or equal to atypical squamous cells of undetermined significance, and 211 (21.1%) were either HPV positive or had abnormal cytology. The VIA, OCT, colposcopy, and biopsies were completed on 183 (86.7%) of 211 women. For VIA alone, the sensitivity and specificity in detecting lesions greater than or equal to CIN 2 was 43% and 96%. With the addition of OCT, the sensitivity increases to 62% with a specificity of 80%.

Conclusions: With the addition of OCT, the sensitivity of VIA increased in all analyses for the detection of greater than or equal to CIN II, with a loss in specificity. We hope that the potential of this technology will be realized when a computer algorithm is generated to aid in image interpretation.

语种英语
WOS记录号WOS:000276899900019
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66556
专题北京大学深圳医院
作者单位1.Imalux Corp, Cleveland, OH USA
2.Northwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA
3.Cleveland Clin, Dept Anat Pathol, Cleveland, OH 44106 USA
4.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen, Peoples R China
5.Cleveland Clin, Dept Obstet & Gynecol, Cleveland, OH 44106 USA
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GB/T 7714
Wulan, Na,Rasool, Nabila,Belinson, Suzanne E.,et al. Study of the Diagnostic Efficacy of Real-Time Optical Coherence Tomography as an Adjunct to Unaided Visual Inspection With Acetic Acid for the Diagnosis of Preinvasive and Invasive Neoplasia of the Uterine Cervix[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2010,20(3):422-427.
APA Wulan, Na.,Rasool, Nabila.,Belinson, Suzanne E..,Wang, Chun.,Rong, Xuan.,...&Belinson, Jerome L..(2010).Study of the Diagnostic Efficacy of Real-Time Optical Coherence Tomography as an Adjunct to Unaided Visual Inspection With Acetic Acid for the Diagnosis of Preinvasive and Invasive Neoplasia of the Uterine Cervix.INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,20(3),422-427.
MLA Wulan, Na,et al."Study of the Diagnostic Efficacy of Real-Time Optical Coherence Tomography as an Adjunct to Unaided Visual Inspection With Acetic Acid for the Diagnosis of Preinvasive and Invasive Neoplasia of the Uterine Cervix".INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 20.3(2010):422-427.
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