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学科主题: 基础医学
题名:
Cancer/Testis Antigen HCA587-Derived Long Peptide Vaccine Generates Potent Immunologic Responses and Antitumor Effects in Mouse Model
作者: Zhang, Lijie; Chen, Juanjuan; Song, Xiao; Wen, Weigang; Li, Yan; Zhang, Yu; Yin, Yanhui1
关键词: Cancer/testis antigen ; HCA587 (MAGE-C2) ; Tumor ; Synthetic long peptide (SLP) ; Vaccine
刊名: ONCOLOGY RESEARCH
发表日期: 2013
DOI: 10.3727/096504014X13887748696789
卷: 21, 期:4, 页:193-200
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CERVICAL-CANCER PATIENTS ; CYTOLYTIC T-LYMPHOCYTES ; HEPATOCELLULAR-CARCINOMA ; MELANOMA PATIENT ; DENDRITIC CELLS ; TUMOR-IMMUNITY ; MAGE-C2 ; IDENTIFICATION ; IMMUNOTHERAPY ; EXPRESSION
英文摘要:

The cancer/testis antigen HCA587 (also known as MAGE-C2), one of the most immunogenic tumor antigens, is overexpressed in a wide spectrum of malignant tumors and can serve as a target for immunotherapy. In this study, we synthesized 14 overlapping (25-35 amino acids) long peptides representing the sequence of the most immunogenic part of the HCA587 protein and evaluated the antigen-specific immune responses and antitumor effects generated by immunization with the synthetic long peptide (SLP) vaccine in a mouse model. HCA587 SLPs in combination with adjuvants CFA and CpG ODN induced potent T-cell responses, which were dominated by type 1 cytokine IFN-gamma-producing CD4(+) T cells as measured by ELISPOT and intracellular cytokine staining assay. Moreover, HCA587 SLP vaccination conferred protection against challenge with HCA587-expressing B16 melanoma in a therapeutic setting. Our findings may provide a scientific basis for the use of HCA587-derived long overlapping peptide vaccine for the treatment of patients with cancer in future clinical trials.

语种: 英语
所属项目编号: 2006AA02Z486 ; 7071006
项目资助者: Ministiy of Science and Technology ; Beijing Municipal Government Foundation for Natural Sciences
WOS记录号: WOS:000335291900003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66560
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Immunol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Lijie,Chen, Juanjuan,Song, Xiao,et al. Cancer/Testis Antigen HCA587-Derived Long Peptide Vaccine Generates Potent Immunologic Responses and Antitumor Effects in Mouse Model[J]. ONCOLOGY RESEARCH,2013,21(4):193-200.
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