IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Cancer/Testis Antigen HCA587-Derived Long Peptide Vaccine Generates Potent Immunologic Responses and Antitumor Effects in Mouse Model
Zhang, Lijie; Chen, Juanjuan; Song, Xiao; Wen, Weigang; Li, Yan; Zhang, Yu; Yin, Yanhui1
关键词Cancer/testis antigen HCA587 (MAGE-C2) Tumor Synthetic long peptide (SLP) Vaccine
刊名ONCOLOGY RESEARCH
2013
DOI10.3727/096504014X13887748696789
21期:4页:193-200
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CERVICAL-CANCER PATIENTS ; CYTOLYTIC T-LYMPHOCYTES ; HEPATOCELLULAR-CARCINOMA ; MELANOMA PATIENT ; DENDRITIC CELLS ; TUMOR-IMMUNITY ; MAGE-C2 ; IDENTIFICATION ; IMMUNOTHERAPY ; EXPRESSION
英文摘要

The cancer/testis antigen HCA587 (also known as MAGE-C2), one of the most immunogenic tumor antigens, is overexpressed in a wide spectrum of malignant tumors and can serve as a target for immunotherapy. In this study, we synthesized 14 overlapping (25-35 amino acids) long peptides representing the sequence of the most immunogenic part of the HCA587 protein and evaluated the antigen-specific immune responses and antitumor effects generated by immunization with the synthetic long peptide (SLP) vaccine in a mouse model. HCA587 SLPs in combination with adjuvants CFA and CpG ODN induced potent T-cell responses, which were dominated by type 1 cytokine IFN-gamma-producing CD4(+) T cells as measured by ELISPOT and intracellular cytokine staining assay. Moreover, HCA587 SLP vaccination conferred protection against challenge with HCA587-expressing B16 melanoma in a therapeutic setting. Our findings may provide a scientific basis for the use of HCA587-derived long overlapping peptide vaccine for the treatment of patients with cancer in future clinical trials.

语种英语
WOS记录号WOS:000335291900003
项目编号2006AA02Z486 ; 7071006
资助机构Ministiy of Science and Technology ; Beijing Municipal Government Foundation for Natural Sciences
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66560
专题北京大学基础医学院_免疫学系
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Immunol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Lijie,Chen, Juanjuan,Song, Xiao,et al. Cancer/Testis Antigen HCA587-Derived Long Peptide Vaccine Generates Potent Immunologic Responses and Antitumor Effects in Mouse Model[J]. ONCOLOGY RESEARCH,2013,21(4):193-200.
APA Zhang, Lijie.,Chen, Juanjuan.,Song, Xiao.,Wen, Weigang.,Li, Yan.,...&Yin, Yanhui.(2013).Cancer/Testis Antigen HCA587-Derived Long Peptide Vaccine Generates Potent Immunologic Responses and Antitumor Effects in Mouse Model.ONCOLOGY RESEARCH,21(4),193-200.
MLA Zhang, Lijie,et al."Cancer/Testis Antigen HCA587-Derived Long Peptide Vaccine Generates Potent Immunologic Responses and Antitumor Effects in Mouse Model".ONCOLOGY RESEARCH 21.4(2013):193-200.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Lijie]的文章
[Chen, Juanjuan]的文章
[Song, Xiao]的文章
百度学术
百度学术中相似的文章
[Zhang, Lijie]的文章
[Chen, Juanjuan]的文章
[Song, Xiao]的文章
必应学术
必应学术中相似的文章
[Zhang, Lijie]的文章
[Chen, Juanjuan]的文章
[Song, Xiao]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。