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Modeling the Interaction of Interferon alpha-1b to Bovine Serum Albumin as a Drug Delivery System
Luo, Qi1,2; Wang, Yihui3; Yang, Hongge3; Liu, Chang3; Ding, Yuan3; Xu, Haifeng3; Wang, Qi1,2; Liu, Yingchun1,2; Xie, Ying3
刊名JOURNAL OF PHYSICAL CHEMISTRY B
2014-07-24
DOI10.1021/jp5041713
118期:29页:8566-8574
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]MOLECULAR-DYNAMICS SIMULATION ; PROTEIN INTERFACES ; IN-VITRO ; NANOPARTICLES ; WATER ; NANOCARRIERS ; STABILITY ; RELEASE ; DOCKING ; PEPTIDE
英文摘要

Protein-based nanoparticles represent a promising approach to carry polypeptide and protein drugs. Using both theory and experimentation, an interferon alpha-1b (IFN) delivery system carried by bovine serum albumin (BSA) nanoparticles was designed. Theoretical results indicate the most probable binding site and interaction mechanism for IFN on BSA. IFN has a higher binding affinity with BSA compared with small chemical drugs. The drug loading is about 8 mg/g, significantly higher than those reported in other literature. The release profiles differ between the nanoparticles prepared by the incorporation method and the adsorption method. The adsorption of IFN on BSA nanoparticles is monolayer adsorption. The fact that IFN was carried successfully by BSA nanoparticles establishes a solid basis for expanding the drug loading field of BSA nanoparticles to proteins and polypeptides.

语种英语
WOS记录号WOS:000339540600013
项目编号21273200 ; J1210042 ; 81202469 ; 201311
资助机构National Natural Science Foundation of China ; Founder of new drug research fund
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66563
专题北京大学药学院_药剂学系
北京大学临床肿瘤学院_介入治疗科
作者单位1.Zhejiang Univ, Soft Matter Res Ctr, Hangzhou 310027, Zhejiang, Peoples R China
2.Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Luo, Qi,Wang, Yihui,Yang, Hongge,et al. Modeling the Interaction of Interferon alpha-1b to Bovine Serum Albumin as a Drug Delivery System[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2014,118(29):8566-8574.
APA Luo, Qi.,Wang, Yihui.,Yang, Hongge.,Liu, Chang.,Ding, Yuan.,...&Xie, Ying.(2014).Modeling the Interaction of Interferon alpha-1b to Bovine Serum Albumin as a Drug Delivery System.JOURNAL OF PHYSICAL CHEMISTRY B,118(29),8566-8574.
MLA Luo, Qi,et al."Modeling the Interaction of Interferon alpha-1b to Bovine Serum Albumin as a Drug Delivery System".JOURNAL OF PHYSICAL CHEMISTRY B 118.29(2014):8566-8574.
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