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学科主题: 药学
题名:
Modeling the Interaction of Interferon alpha-1b to Bovine Serum Albumin as a Drug Delivery System
作者: Luo, Qi1,2; Wang, Yihui3; Yang, Hongge3; Liu, Chang3; Ding, Yuan3; Xu, Haifeng3; Wang, Qi1,2; Liu, Yingchun1,2; Xie, Ying3
刊名: JOURNAL OF PHYSICAL CHEMISTRY B
发表日期: 2014-07-24
DOI: 10.1021/jp5041713
卷: 118, 期:29, 页:8566-8574
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Physical
研究领域[WOS]: Chemistry
关键词[WOS]: MOLECULAR-DYNAMICS SIMULATION ; PROTEIN INTERFACES ; IN-VITRO ; NANOPARTICLES ; WATER ; NANOCARRIERS ; STABILITY ; RELEASE ; DOCKING ; PEPTIDE
英文摘要:

Protein-based nanoparticles represent a promising approach to carry polypeptide and protein drugs. Using both theory and experimentation, an interferon alpha-1b (IFN) delivery system carried by bovine serum albumin (BSA) nanoparticles was designed. Theoretical results indicate the most probable binding site and interaction mechanism for IFN on BSA. IFN has a higher binding affinity with BSA compared with small chemical drugs. The drug loading is about 8 mg/g, significantly higher than those reported in other literature. The release profiles differ between the nanoparticles prepared by the incorporation method and the adsorption method. The adsorption of IFN on BSA nanoparticles is monolayer adsorption. The fact that IFN was carried successfully by BSA nanoparticles establishes a solid basis for expanding the drug loading field of BSA nanoparticles to proteins and polypeptides.

语种: 英语
所属项目编号: 21273200 ; J1210042 ; 81202469 ; 201311
项目资助者: National Natural Science Foundation of China ; Founder of new drug research fund
WOS记录号: WOS:000339540600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66563
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Zhejiang Univ, Soft Matter Res Ctr, Hangzhou 310027, Zhejiang, Peoples R China
2.Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Luo, Qi,Wang, Yihui,Yang, Hongge,et al. Modeling the Interaction of Interferon alpha-1b to Bovine Serum Albumin as a Drug Delivery System[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2014,118(29):8566-8574.
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