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Induction treatment of proliferative lupus nephritis with leflunomide combined with prednisone: a prospective multi-centre observational study
Wang, H. Y.1; Cui, T. G.; Hou, F. F.; Ni, Z. H.; Chen, X. M.; Lu, F. M.; Xu, F. F.; Yu, X. Q.; Zhang, F. S.; Zhao, X. Z.; Zhao, M. H.; Wang, G. B.; Qian, J. Q.; Cai, G. Y.; Zhu, T. Y.; Wang, Y. H.; Jiang, Z. P.; Li, Y. N.; Mei, C. L.; Zou, W. Z.; China Leflunomide Lupus Nephritis
关键词leflunomide lupus nephritis multi-centre observational study
刊名LUPUS
2008
DOI10.1177/0961203308089408
17期:7页:638-644
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]ACTIVE RHEUMATOID-ARTHRITIS ; IMMUNOSUPPRESSIVE AGENT LEFLUNOMIDE ; DOUBLE-BLIND ; IN-VIVO ; ERYTHEMATOSUS ; PLACEBO ; SUPPRESSION ; MECHANISM ; EFFICACY ; SAFETY
英文摘要

To evaluate the efficacy and safety of leflunomide in the treatment of proliferative lupus nephritis, a prospective multi-centre observational study was conducted. Patients with biopsy proven proliferative lupus nephritis were assigned to receive either leflunomide or cyclophosphamide with concomitant prednisone. Leflunomide was given orally with a loading dose of I mg/kg/day for 3 days followed by 30 mg/day. Intravenous cyclophosphamide was administered monthly at a dose of 0.5 g/m(2) of body-surface area. A total of 110 patients were enrolled, 70 in the leflunomide group and 40 in the cyclophosphamide group. The complete remission rate in the leflunomide group was 21% and partial remission rate 52%, as compared with 18% and 55%, respectively, in the cyclophosphamide group. Renal parameters and systemic lupus erythematosus disease activity index improved significantly and similarly in both groups. Serum creatinine decreased or stabilized in both treatment groups. No significant difference was noted with respect to clinical outcome between groups. Repeat biopsy also showed a significant reduction of active lesions in kidney pathology after 6 months of leflunomide treatment. Major adverse events, similar in both treatment groups, included infection, alopecia and hypertension. Leflunomide, compared with cyclophosphamide, in combination with prednisone was effective in the induction therapy of proliferative lupus nephritis and was generally well-tolerated.

语种英语
WOS记录号WOS:000257934200006
引用统计
被引频次:61[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66564
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.So Med Univ, Nanfang Hosp, Div Nephrol, Guangzhou, Guangdong, Peoples R China
3.Shanghai Jiao Tong Univ, Renji Hosp, Div Renal, Shanghai, Peoples R China
4.Chinese Gen Hosp PLA, Dept Nephrol, Kidney Ctr, Beijing, Peoples R China
5.Chinese Gen Hosp PLA, Key Lab PLA, Beijing, Peoples R China
6.Fudan Univ, Div Renal, Huashan Hosp, Shanghai 200433, Peoples R China
7.Wenzhou Med Coll, Div Renal, Affiliated Hosp 1, Wenzhou, Peoples R China
8.Sun Yat Sen Univ, Affiliated Hosp 1, Div Renal, Guangzhou 510275, Guangdong, Peoples R China
9.Harbin Med Coll, Affiliated Hosp 2, Dept Rheumatol, Harbin, Peoples R China
10.Shanghai Changzheng Hosp, Dept Nephrol, Shanghai, Peoples R China
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Wang, H. Y.,Cui, T. G.,Hou, F. F.,et al. Induction treatment of proliferative lupus nephritis with leflunomide combined with prednisone: a prospective multi-centre observational study[J]. LUPUS,2008,17(7):638-644.
APA Wang, H. Y..,Cui, T. G..,Hou, F. F..,Ni, Z. H..,Chen, X. M..,...&China Leflunomide Lupus Nephritis.(2008).Induction treatment of proliferative lupus nephritis with leflunomide combined with prednisone: a prospective multi-centre observational study.LUPUS,17(7),638-644.
MLA Wang, H. Y.,et al."Induction treatment of proliferative lupus nephritis with leflunomide combined with prednisone: a prospective multi-centre observational study".LUPUS 17.7(2008):638-644.
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