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学科主题基础医学
Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation
Liu, Feng-Yu1; Sun, Yan-Ni1; Wang, Fa-Tian1; Li, Qian1; Su, Li1; Zhao, Zi-Fang1; Meng, Xiang-Ling1; Zhao, Hong1; Wu, Xi1; Sun, Qian2; Xing, Guo-Gang1; Wan, You1,2,3
关键词Neuropathic pain Satellite glial cell Mechanical allodynia Fluorocitrate Glial fibrillary acidic protein (GFAP)
刊名BRAIN RESEARCH
2012-01-03
DOI10.1016/j.brainres.2011.10.016
1427期:1页:65-77
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者National Natural Science Foundation of China ; Ministry of Education of China ; Ministry of Science and Technology of China ; Chinese Ministry of Education ; National Natural Science Foundation of China ; Ministry of Education of China ; Ministry of Science and Technology of China ; Chinese Ministry of Education
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]COMPLETE FREUNDS-ADJUVANT ; RAT TRIGEMINAL GANGLION ; GATED CATION CHANNELS ; SENSORY GANGLIA ; MECHANICAL ALLODYNIA ; PATHOLOGICAL PAIN ; UP-REGULATION ; ELECTROPHYSIOLOGICAL PROPERTIES ; BICINCHONINIC ACID ; TACTILE ALLODYNIA
英文摘要

The role of satellite glial cells (SGCs) of sensory ganglia in chronic pain begins to receive interest. The present study aims to investigate the contribution of SGC activation to the development of neuropathic pain. A neuropathic pain model was established by lumbar 5 spinal nerve ligation (SNL), and glial fibrillary acidic protein (GFAP) was used as a marker of SGC activation. It was found that SGCs were activated in the ipsilateral dorsal root ganglia (DRG) increased significantly as early as 4 h following SNL, gradually increased to a peak level at day 7, and then stayed at a high level to the end of the experiment at day 56. SGC activation in the SNL group was significantly higher than that in the sham group at days 1, 3 and 7 after operation. Immunofluorescent double labeling showed that the activated SGCs encircled large, medium-sized and small neurons. The SGCs surrounded the small and medium-sized neurons were preferentially activated in the early phase, but shifted to large diameter neurons as time went on. Continuous infusion of fluorocitrate, a glial metabolism inhibitor, to the affected DRG via mini-osmotic pump for 7 d significantly alleviated mechanical allodynia at day 7. These results suggest that SGCs in the DRG were activated after SNL. SGC activation contributed to the early maintenance of neuropathic pain. (C) 2011 Elsevier B.V. All rights reserved.

语种英语
所属项目编号30600173 ; 81070893 ; 81171042 ; 2007CB512501 ; 109003
资助者National Natural Science Foundation of China ; Ministry of Education of China ; Ministry of Science and Technology of China ; Chinese Ministry of Education ; National Natural Science Foundation of China ; Ministry of Education of China ; Ministry of Science and Technology of China ; Chinese Ministry of Education
WOS记录号WOS:000300118500007
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66565
专题基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Peking Univ, Key Lab Neurosci, Minist Educ, Minist Publ Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Liu, Feng-Yu,Sun, Yan-Ni,Wang, Fa-Tian,et al. Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation[J]. BRAIN RESEARCH,2012,1427(1):65-77.
APA Liu, Feng-Yu.,Sun, Yan-Ni.,Wang, Fa-Tian.,Li, Qian.,Su, Li.,...&Wan, You.(2012).Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation.BRAIN RESEARCH,1427(1),65-77.
MLA Liu, Feng-Yu,et al."Activation of satellite glial cells in lumbar dorsal root ganglia contributes to neuropathic pain after spinal nerve ligation".BRAIN RESEARCH 1427.1(2012):65-77.
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