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学科主题: 临床医学
题名:
Blood oxygen level-dependent MRI for the monitoring of neoadjuvant chemotherapy in breast carcinoma: initial experience
作者: Fan, Bing1; Wang, Xiao-ying1; Yang, Xue-dong1; Zhong, Hua2; Wu, Chun-xue1; Jiang, Xue-xiang1
关键词: Breast cancer ; Neoadjuvant chemotherapy ; Magnetic resonance imaging ; Blood oxygen level-dependent (BOLD)
刊名: MAGNETIC RESONANCE IMAGING
发表日期: 2011-02-01
DOI: 10.1016/j.mri.2010.08.014
卷: 29, 期:2, 页:153-159
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: MAGNETIC-RESONANCE ; PATHOLOGICAL RESPONSE ; CANCER ; TUMORS ; THERAPY ; VOLUME ; FLOW
英文摘要:

Purpose: To determine the feasibility of using R2* map MRI for pretreatment diagnosis and monitoring of tumor response to neoadjuvant chemotherapy (NAC) in patients with breast cancer.

Material and Methods: Twenty-eight women with breast cancer, as evidenced by pathology, underwent MR imaging prior to and after chemotherapy. All patients were examined by conventional MRI and R2* map imaging. Subjects were divided into major histological response (MHR) and non-major histological response (NMHR) groups. Mean R2* values of cancerous and normal glandular tissues were measured before and following NAC. Differences in R2* and Delta R2*% values between these two groups were compared with paired or independent t tests. The relationship between Delta R2*% and histological response was examined using Spearman′s correlation test.

Results: Before NAC, the average R2* values in carcinoma were lower than in normal glandular tissue (P<.05). After two to four cycles of NAC, the R2* values in carcinoma were increased (P<.05), but this change was not significant in normal glandular tissue. After NAC, Delta R2*% was significantly higher in MHR as compared to NMHR (P<.05). The Delta R2*% correlated with the histological response (r=0.581, P<.01).

Conclusion: In women undergoing NAC for breast cancer treatment, R2* and Delta R2*% appear to provide predictive information of tumor response which is probably associated with changes in tumor angiogenesis and tissue oxygenation. R2* map imaging of breasts may therefore be useful in monitoring tumor response to NAC. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000287390500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66566
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
2.Peking Univ, Funct Imaging Ctr, Adv Acad Interdisciplinary, Beijing 100034, Peoples R China

Recommended Citation:
Fan, Bing,Wang, Xiao-ying,Yang, Xue-dong,et al. Blood oxygen level-dependent MRI for the monitoring of neoadjuvant chemotherapy in breast carcinoma: initial experience[J]. MAGNETIC RESONANCE IMAGING,2011,29(2):153-159.
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