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Blood oxygen level-dependent MRI for the monitoring of neoadjuvant chemotherapy in breast carcinoma: initial experience
Fan, Bing1; Wang, Xiao-ying1; Yang, Xue-dong1; Zhong, Hua2; Wu, Chun-xue1; Jiang, Xue-xiang1
关键词Breast cancer Neoadjuvant chemotherapy Magnetic resonance imaging Blood oxygen level-dependent (BOLD)
刊名MAGNETIC RESONANCE IMAGING
2011-02-01
DOI10.1016/j.mri.2010.08.014
29期:2页:153-159
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]MAGNETIC-RESONANCE ; PATHOLOGICAL RESPONSE ; CANCER ; TUMORS ; THERAPY ; VOLUME ; FLOW
英文摘要

Purpose: To determine the feasibility of using R2* map MRI for pretreatment diagnosis and monitoring of tumor response to neoadjuvant chemotherapy (NAC) in patients with breast cancer.

Material and Methods: Twenty-eight women with breast cancer, as evidenced by pathology, underwent MR imaging prior to and after chemotherapy. All patients were examined by conventional MRI and R2* map imaging. Subjects were divided into major histological response (MHR) and non-major histological response (NMHR) groups. Mean R2* values of cancerous and normal glandular tissues were measured before and following NAC. Differences in R2* and Delta R2*% values between these two groups were compared with paired or independent t tests. The relationship between Delta R2*% and histological response was examined using Spearman′s correlation test.

Results: Before NAC, the average R2* values in carcinoma were lower than in normal glandular tissue (P<.05). After two to four cycles of NAC, the R2* values in carcinoma were increased (P<.05), but this change was not significant in normal glandular tissue. After NAC, Delta R2*% was significantly higher in MHR as compared to NMHR (P<.05). The Delta R2*% correlated with the histological response (r=0.581, P<.01).

Conclusion: In women undergoing NAC for breast cancer treatment, R2* and Delta R2*% appear to provide predictive information of tumor response which is probably associated with changes in tumor angiogenesis and tissue oxygenation. R2* map imaging of breasts may therefore be useful in monitoring tumor response to NAC. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000287390500001
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66566
专题北京大学第一临床医学院_放射治疗科
北京大学第一临床医学院_医学影像科
作者单位1.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
2.Peking Univ, Funct Imaging Ctr, Adv Acad Interdisciplinary, Beijing 100034, Peoples R China
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Fan, Bing,Wang, Xiao-ying,Yang, Xue-dong,et al. Blood oxygen level-dependent MRI for the monitoring of neoadjuvant chemotherapy in breast carcinoma: initial experience[J]. MAGNETIC RESONANCE IMAGING,2011,29(2):153-159.
APA Fan, Bing,Wang, Xiao-ying,Yang, Xue-dong,Zhong, Hua,Wu, Chun-xue,&Jiang, Xue-xiang.(2011).Blood oxygen level-dependent MRI for the monitoring of neoadjuvant chemotherapy in breast carcinoma: initial experience.MAGNETIC RESONANCE IMAGING,29(2),153-159.
MLA Fan, Bing,et al."Blood oxygen level-dependent MRI for the monitoring of neoadjuvant chemotherapy in breast carcinoma: initial experience".MAGNETIC RESONANCE IMAGING 29.2(2011):153-159.
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