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学科主题: 基础医学
题名:
Alpha-methylacyl-CoA racemase/P504S overexpression in colorectal carcinoma is correlated with tumor differentiation
作者: Shi, Xueying; Gong, Encong; Wu, Xiaopan
关键词: alpha-methylacyl-CoA racemase ; colorectal carcinoma ; tumor differentiation
刊名: APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
发表日期: 2007-06-01
卷: 15, 期:2, 页:175-180
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
研究领域[WOS]: Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
关键词[WOS]: COENZYME-A-RACEMASE ; PROSTATE-CANCER ; BETA-OXIDATION ; EXPRESSION ; MARKER ; RISK ; IDENTIFICATION ; NUTRITION ; BIOMARKER ; DISEASES
英文摘要:

Alpha-methylacyl-CoA racernase (AMACR)/P504S is an enzyme involved in the metabolism of branched-chain fatty acids. Little is known about correlation of AMACR expression with colorectal carcinoma (CRC) differentiation and prognosis. We investigated the expression of AMACR in 106 cases of primary CRC, and in 47 lymph nodes with metastatic CRC by inummohistochernical analysis. These cases were divided into 3 groups according to the histologic differentiation of the primary tumors. group A included 50 cases of histologically well and moderately differentiated CRCs, 20 of these with lymph node metastasis; group B included 23 cases of well and moderately differentiated CRCs, histologically similar to group A, except these tumors had small foci (less than 20%) of high-grade carcinoma, and 10 of these had lymph node metastasis; group C included 33 cases of poorly differentiated adenocarcinoma and undifferentiated carcinoma, 17 with lymph node metastasis. The results showed the overall positive rates of expression in primary and metastatic CRCs were 59.4% and 46.8%, respectively. Expression in groups A (76.0%) and B (69.6%) was much higher than that in group C (27.3%). In group 13, although overexpression of AMACR in primary tumors was similar to that of group A, it was only seen in 30.0% of group B metastatic tumors, which was similar to the rate of expression in group C (23.5%). In contrast, rates of expression in group A primary and metastatic tumors were similar (80.0% and 75.0%). Positive staining for AMACR in benign epithelium adjacent to tumor was rare ( < 2%). No relation was found between ANIACR expression and overall survival. Our findings support the view that the expression of AMACR in CRC is correlated with tumor differentiation.

语种: 英语
WOS记录号: WOS:000246870200010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66569
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: Peking Univ, Dept Pathol, Sch Basic Med Sci, Beijing 100083, Peoples R China

Recommended Citation:
Shi, Xueying,Gong, Encong,Wu, Xiaopan. Alpha-methylacyl-CoA racemase/P504S overexpression in colorectal carcinoma is correlated with tumor differentiation[J]. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY,2007,15(2):175-180.
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