IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Alpha-methylacyl-CoA racemase/P504S overexpression in colorectal carcinoma is correlated with tumor differentiation
Shi, Xueying; Gong, Encong; Wu, Xiaopan
关键词alpha-methylacyl-CoA racemase colorectal carcinoma tumor differentiation
刊名APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
2007-06-01
15期:2页:175-180
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
研究领域[WOS]Anatomy & Morphology ; Medical Laboratory Technology ; Pathology
关键词[WOS]COENZYME-A-RACEMASE ; PROSTATE-CANCER ; BETA-OXIDATION ; EXPRESSION ; MARKER ; RISK ; IDENTIFICATION ; NUTRITION ; BIOMARKER ; DISEASES
英文摘要

Alpha-methylacyl-CoA racernase (AMACR)/P504S is an enzyme involved in the metabolism of branched-chain fatty acids. Little is known about correlation of AMACR expression with colorectal carcinoma (CRC) differentiation and prognosis. We investigated the expression of AMACR in 106 cases of primary CRC, and in 47 lymph nodes with metastatic CRC by inummohistochernical analysis. These cases were divided into 3 groups according to the histologic differentiation of the primary tumors. group A included 50 cases of histologically well and moderately differentiated CRCs, 20 of these with lymph node metastasis; group B included 23 cases of well and moderately differentiated CRCs, histologically similar to group A, except these tumors had small foci (less than 20%) of high-grade carcinoma, and 10 of these had lymph node metastasis; group C included 33 cases of poorly differentiated adenocarcinoma and undifferentiated carcinoma, 17 with lymph node metastasis. The results showed the overall positive rates of expression in primary and metastatic CRCs were 59.4% and 46.8%, respectively. Expression in groups A (76.0%) and B (69.6%) was much higher than that in group C (27.3%). In group 13, although overexpression of AMACR in primary tumors was similar to that of group A, it was only seen in 30.0% of group B metastatic tumors, which was similar to the rate of expression in group C (23.5%). In contrast, rates of expression in group A primary and metastatic tumors were similar (80.0% and 75.0%). Positive staining for AMACR in benign epithelium adjacent to tumor was rare ( < 2%). No relation was found between ANIACR expression and overall survival. Our findings support the view that the expression of AMACR in CRC is correlated with tumor differentiation.

语种英语
WOS记录号WOS:000246870200010
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66569
专题北京大学基础医学院_病理学系
作者单位Peking Univ, Dept Pathol, Sch Basic Med Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Shi, Xueying,Gong, Encong,Wu, Xiaopan. Alpha-methylacyl-CoA racemase/P504S overexpression in colorectal carcinoma is correlated with tumor differentiation[J]. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY,2007,15(2):175-180.
APA Shi, Xueying,Gong, Encong,&Wu, Xiaopan.(2007).Alpha-methylacyl-CoA racemase/P504S overexpression in colorectal carcinoma is correlated with tumor differentiation.APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY,15(2),175-180.
MLA Shi, Xueying,et al."Alpha-methylacyl-CoA racemase/P504S overexpression in colorectal carcinoma is correlated with tumor differentiation".APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 15.2(2007):175-180.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Alpha-methylacyl-CoA(567KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shi, Xueying]的文章
[Gong, Encong]的文章
[Wu, Xiaopan]的文章
百度学术
百度学术中相似的文章
[Shi, Xueying]的文章
[Gong, Encong]的文章
[Wu, Xiaopan]的文章
必应学术
必应学术中相似的文章
[Shi, Xueying]的文章
[Gong, Encong]的文章
[Wu, Xiaopan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Alpha-methylacyl-CoA racemase P504S overexpression in colorectal carcinoma is correlated with tumor differentiation.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。