IR@PKUHSC  > 北京大学药学院  > 药剂学系
学科主题药学
Absorption mechanism of cyclosporine a loaded pH-sensitive nanoparticles in rats
Wang, Xue-Qing1; Dai, Jun-Dong1; Zhang, Hua1; Zhang, Xuan1; Wang, Jian-Cheng1; Zhang, Qiang1,2
关键词cyclosporine A pH-sensitive nanoparticles absorption mechanism gastro-intestinal tract rat
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
2008-05-01
DOI10.1166/jnn.2008.359
8期:5页:2422-2431
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]EPITHELIAL-CELL MONOLAYERS ; ORAL BIOAVAILABILITY ; VIVO EVALUATION ; DRUG-DELIVERY ; PROTEIN ; DERIVATIVES ; FORMULATION ; LIPOSOMES ; TRANSPORT ; INSULIN
英文摘要

CyA was prepared into CyA Eudragit S100 nanoparticles (CyA-S100 NP) and the mechanisms of CyA-S100 NP improving the CyA absorption in gastrointestinal tract (GI) were studied systematically in rats. In the GI distribution study, the emptying rates of CyA-S100 NP in duodenum, jejunum, ileum and colon were all lower than these of Neoral (R), while in stomach, it was larger than that of Neoral (R). In in situ recirculating intestine perfusion experiment, the largest absorption in CyA-S100 NP group occurred in ileum while that in Neoral (R) group arised in duodenum. The sequence of (AUC(0-240) min)/A for CyA-S100 NP and Neoral (R) group was ileum > duodenum > jejunum > colon and duodenum > jejunum > ileum > colon, respectively. CyA in nanoparticles degradated by luminal contents and subcellular fractions were more slowly than these in Neoral (R), suggesting the significant protect effect of nanoparticles. Mucoadhesion study in small intestine showed that among all the parts of intestine, CyA-S100 NP exhibited larger mucoadhesive characteristics than Neoral (R) microemulsion. The sequence of mucoadhesion for CyA-S100 NP group was duodenum > ileum > jejunum and colon, while that for Neoral (R) group was duodenum > ileum, jejunum and colon, suggesting different site-specific behaves. These results illustrated that nanoparticles increased the absorption of CyA could be attributed to fast stomach empting rate, absorption site specific, small degradation rate by luminal contents, high bioadhension of nanoparticles to intestine mucosa and the use of P-Glycoprotein inhibitor if there is any. This investigation is helpful for the dosage form design for other peptide or protein drugs.

语种英语
WOS记录号WOS:000256160300029
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66571
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimetr Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xue-Qing,Dai, Jun-Dong,Zhang, Hua,et al. Absorption mechanism of cyclosporine a loaded pH-sensitive nanoparticles in rats[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2008,8(5):2422-2431.
APA Wang, Xue-Qing,Dai, Jun-Dong,Zhang, Hua,Zhang, Xuan,Wang, Jian-Cheng,&Zhang, Qiang.(2008).Absorption mechanism of cyclosporine a loaded pH-sensitive nanoparticles in rats.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,8(5),2422-2431.
MLA Wang, Xue-Qing,et al."Absorption mechanism of cyclosporine a loaded pH-sensitive nanoparticles in rats".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 8.5(2008):2422-2431.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Xue-Qing]的文章
[Dai, Jun-Dong]的文章
[Zhang, Hua]的文章
百度学术
百度学术中相似的文章
[Wang, Xue-Qing]的文章
[Dai, Jun-Dong]的文章
[Zhang, Hua]的文章
必应学术
必应学术中相似的文章
[Wang, Xue-Qing]的文章
[Dai, Jun-Dong]的文章
[Zhang, Hua]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。